Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS6823 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL18 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL18.
- Description
- Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1Ï«, IL-1ÉÇ and IL-1ÎÛ/IL-18 and a specific receptor antagonist, IL-1RÏ«. IL-1Ï« and IL-1ÉÇ play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1ÎÛ) has been shown to augment the secretion of IFN-ÎÛ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1Ï« and IL-1ÉÇ respectively over the 12 ÉÇ-strands of the ÉÇ-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1ÉÇ pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-ÎÛ-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of IL18 pAb