66310-1-Ig

antibody from Proteintech Group

Targeting: TRAF3 CAP-1, CD40bp, CRAF1, LAP1, RNF118

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66310-1-Ig

Provider

Proteintech Group

Product name

TRAF3 antibody

Antibody type

Monoclonal

Description

KD/KO validated TRAF3 antibody (Cat. #66310-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1E3F4

Vial size

20ul, 150ul

References

Submitted references

Migration and invasion inhibitory protein inhibits M2 macrophage polarization to suppress colorectal cancer progression through the STING-NFκB2-IL10 axis.

Chen S, Lu C, Li J, Shen X, Sun Y
Cancer biology & medicine 2026 Jan 14;23(1):86-106

---

Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity.

Rakib A, Mandal M, Al Mamun MA, Kiran S, Yasmen N, Li L, Collier DM, Jiang J, Park F, Singh UP
Frontiers in immunology 2025;16:1501307

---

Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma.

Zheng Y, Chen D, Xu Y, Xu X, Song P, Wu X, Tan L, Mao Y, Chen Y
Cancer gene therapy 2025 Nov;32(11):1206-1217

---

Bovine coronavirus Nsp14 protein promotes viral replication by degrading TRAF3 to inhibit interferon production.

Sun H, Liu Y, Yang X, Qin W, Lu X, Wang Y, Tong W, Yu H, Zheng H, Tong G, Shan T, Kong N
Veterinary microbiology 2025 Nov;310:110708

---

AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3.

Jia M, Chen X, Guo W, Ma D, Wang P, Niu H, Liu C, Lin X, Lu Q, Wang J, Zheng X, Sun Q, Gao C, Yuan H
Redox biology 2025 May;82:103581

---

GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs.

Wang Y, Wang C, Gong Y, Li Q, Liu M, Sun H
Tissue & cell 2025 Jun;94:102790

---

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.

Cheng M, Xu B, Sun Y, Wang J, Lu Y, Shi C, Pan T, Zhao W, Li X, Song X, Wang J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Zeng Y, Yang D, Wang C, Cao X
mBio 2024 Sep 11;15(9):e0204324

---

Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.

Ma H, Suleman M, Zhang F, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B, Li Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476

---

RBM14 inhibits the replication of porcine epidemic diarrhea virus by recruiting p62 to degrade nucleocapsid protein through the activation of autophagy and interferon pathway.

Wang X, Tong W, Yang X, Zhai H, Qin W, Liu C, Zheng H, Yu H, Tong G, Zhang Z, Kong N, Shan T
Journal of virology 2024 Mar 19;98(3):e0018224

---

MicroRNA-322 overexpression reduces neural tube defects in diabetic pregnancies.

Wang G, Song S, Shen WB, Reece EA, Yang P
American journal of obstetrics and gynecology 2024 Feb;230(2):254.e1-254.e13

---

TRAF3/STAT6 axis regulates macrophage polarization and tumor progression.

Shi JH, Liu LN, Song DD, Liu WW, Ling C, Wu FX, Wang TT, Liu B, Cui NP, Qin Y, Ni ZY
Cell death and differentiation 2023 Aug;30(8):2005-2016

---

N protein of PEDV plays chess game with host proteins by selective autophagy.

Zhai X, Kong N, Zhang Y, Song Y, Qin W, Yang X, Ye C, Ye M, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Zhang G, Tong G, Shan T
Autophagy 2023 Aug;19(8):2338-2352

---

ATG4B hinders porcine epidemic diarrhea virus replication through interacting with TRAF3 and activating type-I IFN signaling.

Dong S, Kong N, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Li Y, Tong G, Shan T
Veterinary microbiology 2022 Oct;273:109544

---

Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.

Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939

---

TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.

Dong S, Kong N, Zhang Y, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T
Journal of virology 2022 May 25;96(10):e0007022

---

FUBP3 Degrades the Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and Induces the Production of Type I Interferon.

Dong S, Kong N, Wang C, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T
Journal of virology 2022 Jul 13;96(13):e0061822

---

Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Antagonizes Interferon-β Production via Blocking the Interaction Between TRAF3 and TBK1.

Zhou Z, Sun Y, Xu J, Tang X, Zhou L, Li Q, Lan T, Ma J
Frontiers in immunology 2021;12:573078

---

Hypoxic colorectal cancer-derived extracellular vesicles deliver microRNA-361-3p to facilitate cell proliferation by targeting TRAF3 via the noncanonical NF-κB pathways.

Li J, Yang P, Chen F, Tan Y, Huang C, Shen H, Peng C, Feng Y, Sun Y
Clinical and translational medicine 2021 Mar;11(3):e349

---

DJ-1 activates the noncanonical NF-κB pathway via interaction with Cezanne to inhibit the apoptosis and promote the proliferation of Ishikawa cells.

Zhu QZ, Liu HY, Zhao XY, Qiu LJ, Zhou TT, Wang XY, Chen HP, Xiao ZQ
Molecular biology reports 2021 Aug;48(8):6075-6083

---

Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.

Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378

---

MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation.

Du X, Wang S, Liu X, He T, Lin X, Wu S, Wang D, Li J, Huang W, Yang H
Cancer cell international 2020;20:502