18099-1-AP

antibody from Proteintech Group

Targeting: TRAF3 CAP-1, CD40bp, CRAF1, LAP1, RNF118

Provider product page for 18099-1-AP

Western blot

ELISA

Immunoprecipitation

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [34]
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Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 18099-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18099-1-AP, RRID:AB_10837364
Product name: TRAF3 antibody
Antibody type: Polyclonal
Description: KD/KO validated TRAF3 antibody (Cat. #18099-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TRAF3 protein structure - 18099-1-AP shown in red.

Submitted references The miR-2110/TRAF3 axis is associated with endothelial dysfunction and atherosclerosis in coronary heart disease.

Tran T, Wang ZY, Li PS, Yang Y, Zhang YW, Zhang SM, Dinh P, Le N, Pham T, Huang L, Chen NY, Peng JH, Pan SL
Biochemistry and biophysics reports 2026 Mar;45:102508

The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.

Pan M, Song Z, Wang M, Zhao M, Fang S, Jin F, Tan Q, Xu W, Che L, Liu N, Sui L, Liu Q, Hou Z, Zhao Y
Microbiology spectrum 2026 Mar 3;14(3):e0248425

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.

Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L
Nucleic acids research 2026 Feb 5;54(4)

Neuroprotective effects of hyperbaric oxygen therapy on vascular cognitive impairment in hypoperfused mice via miR-137-3p/TRAF3 pathway.

Yang L, Zhu HZ, Xie L, Yang J, Wei HT, Yu QT, Li H, Yang M, Li Z
Translational psychiatry 2025 Nov 29;15(1):537

AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3.

Jia M, Chen X, Guo W, Ma D, Wang P, Niu H, Liu C, Lin X, Lu Q, Wang J, Zheng X, Sun Q, Gao C, Yuan H
Redox biology 2025 May;82:103581

TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning.

He YB, Li JY, Chen SL, Ye R, Fei YR, Tong SY, Song YX, Wang C, Zhang L, Fang J, Shang Y, Zhang ZZ, Chen J, Yang AZ, Liu J, Liu YL
BMC pregnancy and childbirth 2025 May 31;25(1):637

A genome-wide CRISPR-Cas9 knockout screen using dynamin knockout cells identifies Nf2 and Traf3 as genes involved in dynamin-independent endocytosis.

Takahashi S, Maehara M, Nishihara C, Iwata H, Shibutani S
Experimental cell research 2025 Mar 15;446(2):114470

Bioinformatics analysis and validation of novel biomarkers and competitive endogenous RNA networks involved in pyroptosis in diabetic nephropathy.

Wu S, Yao L, Zhang W, Chen P, Jiang J, Ma Y
Scientific reports 2025 Feb 14;15(1):5530

TRAF2 associates with cullin neddylation complex assembly.

Wang T, Zhang Q, Xu Y, Yan R, Pan Y, Xuan Y, Shen M, Chen X, Zhu H, Ke X, Qu Y, Zhang X
The FEBS journal 2024 Oct;291(20):4473-4488

TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.

Gu Y, Liang C
International urology and nephrology 2024 May;56(5):1639-1648

Deep profiling of potential substrate atlas of porcine epidemic diarrhea virus 3C-like protease.

Zhou J, Sun P, Wang Y, Qiu R, Yang Z, Guo J, Li Z, Xiao S, Fang L
Journal of virology 2024 May 14;98(5):e0025324

The E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation.

Cheng M, Lu Y, Wang J, Wang H, Sun Y, Zhao W, Wang J, Shi C, Luo J, Gao M, Yu T, Wang J, Guan J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Cao X, Yang D, Wang C, Zeng Y
Cell death and differentiation 2024 Dec;31(12):1746-1760

RANKL/RANK contributes to the pathological process of type 2 diabetes mellitus through TRAF3 activation of NIK.

Yu J, Tian N, Hu Y, Jin T
International immunopharmacology 2024 Dec 5;142(Pt A):113008

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.

Li H, Wan L, Liu M, Ma E, Huang L, Yang Y, Li Q, Fang Y, Li J, Han B, Zhang C, Sun L, Hou X, Li H, Sun M, Qian S, Duan X, Zhao R, Yang X, Chen Y, Wu S, Zhang X, Zhang Y, Cheng G, Chen G, Gao Q, Xu J, Hou L, Wei C, Zhong H
PLoS pathogens 2024 Aug;20(8):e1012291

Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice.

Khaw YM, Anwar S, Zhou J, Kawano T, Lin PC, Otero A, Barakat R, Drnevich J, Takahashi T, Ko CJ, Inoue M
EMBO reports 2023 Mar 6;24(3):e54228

TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79

Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.

Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939

TDRD3 is an antiviral restriction factor that promotes IFN signaling with G3BP1.

Deater M, Tamhankar M, Lloyd RE
PLoS pathogens 2022 Jan;18(1):e1010249

The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.

Zong X, Xiao X, Shen B, Jiang Q, Wang H, Lu Z, Wang F, Jin M, Min J, Wang F, Wang Y
Nucleic acids research 2021 Jun 4;49(10):5537-5552

Evolutionary history and functional characterization of Lj-TICAM-a and Lj-TICAM-b formed via lineage-specific tandem duplication in lamprey (Lampetra japonica).

Geng M, Hua Y, Liu Y, Quan J, Hu X, Su P, Li Y, Liu X, Li Q, Zhu T
Genomics 2021 Jul;113(4):2756-2768

TNF receptor-associated factor 3 restrains B-cell receptor signaling in normal and malignant B cells.

Whillock AL, Ybarra TK, Bishop GA
The Journal of biological chemistry 2021 Jan-Jun;296:100465

Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3.

Sun Y, Zhou Y, Shi Y, Zhang Y, Liu K, Liang R, Sun P, Chang X, Tang W, Zhang Y, Li J, Wang S, Zhu Y, Han X
Cell reports 2021 Jan 5;34(1):108576

Enterovirus D68 Protease 2A(pro) Targets TRAF3 To Subvert Host Innate Immune Responses.

Kang J, Pang Z, Zhou Z, Li X, Liu S, Cheng J, Liu P, Tan W, Wang Z, Wang T
Journal of virology 2021 Jan 13;95(3)

Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.

Zhou W, Zhong Z, Lin D, Liu Z, Zhang Q, Xia H, Peng S, Liu A, Lu Z, Wang Y, Ye S, Ye Q
Cell death & disease 2021 Feb 24;12(2):211

The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice.

Wei Y, Zeng Y, Zhang X, Xu S, Wang Z, Du Y, Zhang B, Lei CQ, Zhu Q
Journal of virology 2020 Nov 23;94(24)

TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.

Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y
The Journal of experimental medicine 2020 Jul 6;217(7)

Decreased miR-218-5p Levels as a Serum Biomarker in Bone Metastasis of Prostate Cancer.

Peng P, Chen T, Wang Q, Zhang Y, Zheng F, Huang S, Tang Y, Yang C, Ding W, Ren D, Huang Z, Guo Y
Oncology research and treatment 2019;42(4):165-185

TRAF3 Is Required for NF-κB Pathway Activation Mediated by HTLV Tax Proteins.

Fochi S, Bergamo E, Serena M, Mutascio S, Journo C, Mahieux R, Ciminale V, Bertazzoni U, Zipeto D, Romanelli MG
Frontiers in microbiology 2019;10:1302

Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.

Robeson AC, Lindblom KR, Wojton J, Kornbluth S, Matsuura K
The EMBO journal 2018 Jul 13;37(14)

The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-β Production by Targeting TNF Receptor-Associated Factor 3.

Qian W, Wei X, Guo K, Li Y, Lin X, Zou Z, Zhou H, Jin M
Frontiers in immunology 2017;8:779

Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.

Yao H, Sun Y, Song S, Qi Y, Tao X, Xu L, Yin L, Han X, Xu Y, Li H, Sun H, Peng J
Frontiers in pharmacology 2017;8:120

Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.

Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, Liu X, Wang Y
Mediators of inflammation 2017;2017:9891673

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters 2017 Nov 1;408:60-70

Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.

Chen HW, Yang YK, Xu H, Yang WW, Zhai ZH, Chen DY
Scientific reports 2015 Oct 12;5:14770

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Raji cells were subjected to SDS PAGE followed by western blot with 18099-1-AP(TRAF3 antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TRAF3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TRAF3. This antibody recognizes human,mouse,rat antigen. The TRAF3 antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 18099-1-AP.pdf

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