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- References [13]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 10472-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10472-1-AP, RRID:AB_2173382
- Product name
- PTPN23 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PTPN23 antibody (Cat. #10472-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation.
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival.
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation.
Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor-dependent manner.
Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.
Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase.
Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.
Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB.
Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.
The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration.
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Stoneham CA, Langer S, De Jesus PD, Wozniak JM, Lapek J, Deerinck T, Thor A, Pache L, Chanda SK, Gonzalez DJ, Ellisman M, Guatelli J
PLoS pathogens 2021 Nov;17(11):e1009409
PLoS pathogens 2021 Nov;17(11):e1009409
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
Kazan JM, Desrochers G, Martin CE, Jeong H, Kharitidi D, Apaja PM, Roldan A, St Denis N, Gingras AC, Lukacs GL, Pause A
iScience 2021 Nov 19;24(11):103274
iScience 2021 Nov 19;24(11):103274
His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation.
Parkinson G, Roboti P, Zhang L, Taylor S, Woodman P
Journal of cell science 2021 Nov 1;134(21)
Journal of cell science 2021 Nov 1;134(21)
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival.
Radulovic M, Schink KO, Wenzel EM, Nähse V, Bongiovanni A, Lafont F, Stenmark H
The EMBO journal 2018 Nov 2;37(21)
The EMBO journal 2018 Nov 2;37(21)
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation.
Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nähse V, Carlson A, Brech A, Stenmark H, Raiborg C
Nature communications 2018 Jul 26;9(1):2932
Nature communications 2018 Jul 26;9(1):2932
Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor-dependent manner.
Gosney JA, Wilkey DW, Merchant ML, Ceresa BP
The Journal of biological chemistry 2018 Apr 20;293(16):5895-5908
The Journal of biological chemistry 2018 Apr 20;293(16):5895-5908
Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.
Goodwin JM, Dowdle WE, DeJesus R, Wang Z, Bergman P, Kobylarz M, Lindeman A, Xavier RJ, McAllister G, Nyfeler B, Hoffman G, Murphy LO
Cell reports 2017 Sep 5;20(10):2341-2356
Cell reports 2017 Sep 5;20(10):2341-2356
Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase.
Zhang S, Fan G, Hao Y, Hammell M, Wilkinson JE, Tonks NK
Genes & development 2017 Oct 1;31(19):1939-1957
Genes & development 2017 Oct 1;31(19):1939-1957
Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.
Gahloth D, Levy C, Walker L, Wunderley L, Mould AP, Taylor S, Woodman P, Tabernero L
Structure (London, England : 1993) 2017 Jul 5;25(7):1011-1024.e4
Structure (London, England : 1993) 2017 Jul 5;25(7):1011-1024.e4
Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB.
Ali N, Zhang L, Taylor S, Mironov A, Urbé S, Woodman P
Current biology : CB 2013 Mar 18;23(6):453-61
Current biology : CB 2013 Mar 18;23(6):453-61
Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.
Tanaka K, Kondo K, Kitajima K, Muraoka M, Nozawa A, Hara T
The Journal of biological chemistry 2013 Aug 16;288(33):23990-9
The Journal of biological chemistry 2013 Aug 16;288(33):23990-9
The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration.
Chen DY, Li MY, Wu SY, Lin YL, Tsai SP, Lai PL, Lin YT, Kuo JC, Meng TC, Chen GC
Journal of cell science 2012 Oct 15;125(Pt 20):4841-52
Journal of cell science 2012 Oct 15;125(Pt 20):4841-52
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Stefani F, Zhang L, Taylor S, Donovan J, Rollinson S, Doyotte A, Brownhill K, Bennion J, Pickering-Brown S, Woodman P
Current biology : CB 2011 Jul 26;21(14):1245-50
Current biology : CB 2011 Jul 26;21(14):1245-50
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 10472-1-AP(PTPN23 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-PTPN23 (IP:10472-1-AP, 5ug; Detection:10472-1-AP 1:500) with HeLa cells lysate 1000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PTPN23 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PTPN23. This antibody recognizes human,mouse,rat antigen. The PTPN23 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
