BAF986

antibody from R&D Systems

Targeting: GAS6 AXLLG, AXSF, DKFZp666G247, FLJ34709

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

BAF986

Provider

R&D Systems

Product name

Mouse Gas6 Biotinylated Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects mouse Gas6 in ELISAs and Western blots. In sandwich immunoassays, less than 10% cross-reactivity with recombinant human Gas6 is observed and less than 1% cross-reactivity with recombinant mouse Gas1 is observed.

Reactivity

Mouse

Host

Goat

Conjugate

Biotin

Antigen sequence

CAA42507


Isotype

IgG

Vial size

50 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.

Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ
The Journal of clinical investigation 2017 Jan 3;127(1):183-198

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The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

Fujimori T, Grabiec AM, Kaur M, Bell TJ, Fujino N, Cook PC, Svedberg FR, MacDonald AS, Maciewicz RA, Singh D, Hussell T
Mucosal immunology 2015 Sep;8(5):1021-1030

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Role of Gas6 in erythropoiesis and anemia in mice.

Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P
The Journal of clinical investigation 2008 Feb;118(2):583-96