10642-1-AP

antibody from Proteintech Group

Targeting: PGF D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10642-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10642-1-AP, RRID:AB_2161061

Product name

Placental Growth Factor antibody

Antibody type

Polyclonal

Description

KD/KO validated Placental Growth Factor antibody (Cat. #10642-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Identification of a prognostic model using immune related genes combined with tumour mutational burden and T cell infiltration in triple-negative breast cancer.

Meng Y, Han ZX, Zhu J, Wang Y, Huang YQ, Zou ZH, Ma YY, Li YF, Wang H, Li Y, Lian L, Wang WJ
Oncology letters 2026 Jun;31(6):242

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Molecular mechanism of Flt-1 protein and the regulation of monocytes modulate endothelial cell in wound healing sites via PGF/FLT1 signaling.

Lu L, Wu Y, Lu C, Liang F, Gu S, Sun S, Tang Q, Tang Q
International journal of biological macromolecules 2025 May;307(Pt 3):142192

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Placental Pathology and Placental Growth Factor (PlGF)/Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Pathway Expression Evaluation in Fetal Congenital Heart Defects.

Bolunduț AC, Mureșan XM, Suflețel RT, Mocan LP, Pîrv S, Șușman S, Mihu CM
Life (Basel, Switzerland) 2025 May 22;15(6)

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PRMT1 inhibition enhances the cardioprotective effect of adipose-derived mesenchymal stem cells against myocardial infarction through RUNX1.

Du D, Wang T, Sun Y, Zhang Y, Zhang B, Shao J, Yang M, Huang C, Zuo S, Wu N
Stem cell research & therapy 2025 Jun 3;16(1):279

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Pan-cancer human brain metastases atlas at single-cell resolution.

Xing X, Zhong J, Biermann J, Duan H, Zhang X, Shi Y, Gao Y, He K, Zhai D, Luo F, Lai Y, Xiao F, Wang W, Wang M, Xu J, Liu H, Tang J, Chu L, Chen T, D'Souza EK, Caprio L, Ebel L, Biswas D, Cottarelli A, Mou Y, Izar B, Zhang N, Bai F
Cancer cell 2025 Jul 14;43(7):1242-1260.e9

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Electroacupuncture normalized tumor vasculature by downregulating glyoxalase-1 to polarize tumor-associated macrophage to M1 phenotype in triple-negative breast cancer.

Qi X, Lian Y, Fan Z, Wang H, Jiang H, He M, Li L, Huang J, Wan Y
International immunopharmacology 2025 Feb 6;147:113988

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Ectopic Expansion of Pulmonary Vasculature in Fibrotic Lung Disease and Lung Adenocarcinoma Marked by Proangiogenic COL15A1+ Endothelial Cells.

Engelbrecht E, Kooistra T, Burg N, Hariri L, Nguyen T, Brazee P, Hla T, Gochuico BR, Knipe RS
Pulmonary circulation 2025 Apr;15(2):e70102

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Co-inhibition of PGF and VEGFA enhances the effectiveness of immunotherapy in bladder cancer.

Yang X, Zheng H, Huang J, Liu Y, Li Y, Zhang B, Sun C, Li Y, Thiery JP, Wu S
International journal of medical sciences 2024;21(15):2870-2882

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VEGF-B prevents chronic hyperglycemia-induced retinal vascular leakage by regulating the CDC42-ZO1/VE-cadherin pathway.

Xu Y, Peng Y, Wu X, Ni F, Sun D, Zhang P, Yang Y, Yan M, Mi J, Tian G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70019

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Prenatal triphenyl phosphate exposure impairs placentation and induces preeclampsia-like symptoms in mice.

Liu Q, Jiang M, Lu X, Hong J, Sun Y, Yang C, Chen Y, Chai X, Tang H, Liu X
Environmental research 2024 Sep 15;257:119159

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Human amniotic epithelial cells improve uterine spiral artery remodeling to ameliorate preeclampsia in a rat model†.

Geng L, Qin Z, Han TL, Zhou Y, Zhong X, Zhang G, Dong X
Biology of reproduction 2024 Oct 14;111(4):906-918

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MiR-424-5p Inhibits Proliferation, Migration, Invasion and Angiogenesis of the HTR-8/SVneo Cells Through Targeting LRP6 Mediated β-catenin.

Fei K, Zhang H, Zhang W, Liao C
Reproductive sciences (Thousand Oaks, Calif.) 2024 Nov;31(11):3428-3439

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Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma.

Balaji S, Rao A, Saraswathi KK, Sethu Nagarajan R, Santhi R, Kim U, Muthukkaruppan V, Vanniarajan A
Medical oncology (Northwood, London, England) 2024 Jun 4;41(7):168

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Vasorin Exocytosed from Glioma Cells Facilitates Angiogenesis via VEGFR2/AKT Signaling Pathway.

Zhong Y, Kang H, Ma Z, Li J, Qin Z, Zhang Z, Li P, Zhong Y, Wang L
Molecular cancer research : MCR 2024 Jul 2;22(7):668-681

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Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma.

Fan M, Lu L, Shang H, Lu Y, Yang Y, Wang X, Lu H
Aging 2024 Apr 1;16(9):7578-7595

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HIF-1α inhibitor YC-1 suppresses triple-negative breast cancer growth and angiogenesis by targeting PlGF/VEGFR1-induced macrophage polarization.

Li Y, Zhang MZ, Zhang SJ, Sun X, Zhou C, Li J, Liu J, Feng J, Lu SY, Pei-Jun L, Wang JC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114423

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Ulinastatin ameliorates preeclampsia induced by N(gamma)-nitro-l-arginine methyl ester in a rat model via inhibition of the systemic and placental inflammatory response.

Yu Z, Liu Y, Zhang Y, Cui J, Dong Y, Zhang L, Liu P, Hao Y, Xu Y, Wang J
Journal of hypertension 2023 Jan 1;41(1):150-158

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Alzheimer's Amyloid β Peptide Induces Angiogenesis in an Alzheimer's Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions.

Sheikh AM, Yano S, Tabassum S, Mitaki S, Michikawa M, Nagai A
International journal of molecular sciences 2023 Feb 24;24(5)

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The effect of cold exposure on the levels of glucocorticoids, 11-hydroxysteroid dehydrogenase 2, and placental vascularization in a rat model.

Zhang QJ, Chen SW, Xu X, Zhang HL, Yan JY
European review for medical and pharmacological sciences 2023 Dec;27(24):11961-11974

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Development and Validation of Novel Prognostic Models for Immune-Related Genes in Osteosarcoma.

Li J, Su L, Xiao X, Wu F, Du G, Guo X, Kong F, Yao J, Zhu H
Frontiers in molecular biosciences 2022;9:828886

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Analysis of the potential association between ferroptosis and immune in hepatocellular carcinoma and their relationship with prognosis.

Wen K, Yang F, Hu L, Shi J, Mui S, Wang W, Liao H, Li H, Xiao Z, Yan Y
Frontiers in oncology 2022;12:1031156

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Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.

Jiang Y, Chen A, Kline D, Liu Q, Ma J, Wang Y, Zhang T, Qian J, Nelson L, Prasadan K, Hu B, Gittes GK, Xiao X
Diabetes, obesity & metabolism 2022 Sep;24(9):1721-1733

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MAPK-RAP1A Signaling Enriched in Hepatocellular Carcinoma Is Associated With Favorable Tumor-Infiltrating Immune Cells and Clinical Prognosis.

Li H, Han G, Li X, Li B, Wu B, Jin H, Wu L, Wang W
Frontiers in oncology 2021;11:649980

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Identification of a novel cancer stem cell subpopulation that promotes progression of human fatal renal cell carcinoma by single-cell RNA-seq analysis.

Pan XW, Zhang H, Xu D, Chen JX, Chen WJ, Gan SS, Qu FJ, Chu CM, Cao JW, Fan YH, Song X, Ye JQ, Zhou W, Cui XG
International journal of biological sciences 2020;16(16):3149-3162

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Occurrence of Fibrotic Tumor Vessels in Grade I Meningiomas Is Strongly Associated with Vessel Density, Expression of VEGF, PlGF, IGFBP-3 and Tumor Recurrence.

Hess K, Spille DC, Adeli A, Sporns PB, Zitta K, Hummitzsch L, Pfarr J, Stummer W, Brokinkel B, Berndt R, Albrecht M
Cancers 2020 Oct 21;12(10)

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MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.

Tao J, Xia LZ, Liang L, Chen Y, Wei D, Meng J, Wu S, Wang Z
Placenta 2020 Nov;101:176-184

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The role and mechanism of asymmetric dimethylarginine in fetal growth restriction via interference with endothelial function and angiogenesis.

Dai Y, Zhang J, Liu R, Xu N, Yan SB, Chen Y, Li TH
Journal of assisted reproduction and genetics 2020 May;37(5):1083-1095

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Prolactin (PRL), placenta growth factor (PIGF) and nerve growth factor receptor (NGFR) as biomarkers for early diagnosis and prognosis in patients with esophageal squamous cell carcinoma (ESCC).

Ai X, Zhu X, Zuo J
Translational cancer research 2020 Feb;9(2):647-656

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"Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines.

Drwal E, Rak A, Tworzydło W, Gregoraszczuk EŁ
Reproductive toxicology (Elmsford, N.Y.) 2020 Aug;95:1-10

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PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

Ma Q, Gu JT, Wang B, Feng J, Yang L, Kang XW, Duan P, Sun X, Liu PJ, Wang JC
European journal of pharmacology 2019 Nov 15;863:172696

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The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer.

Li H, Jin Y, Hu Y, Jiang L, Liu F, Zhang Y, Hao Y, Chen S, Wu X, Liu Y
Cancer science 2018 May;109(5):1532-1544

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Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia.

Ma Y, Kong LR, Ge Q, Lu YY, Hong MN, Zhang Y, Ruan CC, Gao PJ
Journal of cellular and molecular medicine 2018 Feb;22(2):1034-1046

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Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.

Song Y, Tang C, Yin C
Biomaterials 2018 Dec;185:117-132

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Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction.

Wu WB, Xu YY, Cheng WW, Yuan B, Zhao JR, Wang YL, Zhang HJ
Reproduction (Cambridge, England) 2017 Sep;154(3):319-329

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Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia.

Ehrlich L, Hoeller A, Golic M, Herse F, Perschel FH, Henrich W, Dechend R, Huppertz B, Verlohren S
Hypertension in pregnancy 2017 May;36(2):175-185

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Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection.

Hedlund E, Karlsson M, Osborn T, Ludwig W, Isacson O
Brain : a journal of neurology 2010 Aug;133(Pt 8):2313-30

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

MCF7 cells were subjected to SDS PAGE followed by western blot with 10642-1-AP(PGF antibody) at dilution of 1:300

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The PIGF antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PIGF. This antibody recognizes human antigen. The PIGF antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

10642-1-AP.pdf

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