Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN358107 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Cyclin-Dependent Kinase 7 (CDK7) (pThr170) antibody
- Antibody type
- Polyclonal
- Antigen
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T170 of human CDK7.
- Description
- Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- pThr170
- Vial size
- 0.4 mL
- Concentration
- 0.25 mg/mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.
Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr.
The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H.
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.
Cell cycle-dependent stimulation of the HIV-1 promoter by Tat-associated CAK activator.
Zhou M, Deng L, Kashanchi F, Brady JN, Shatkin AJ, Kumar A
Proceedings of the National Academy of Sciences of the United States of America 2003 Oct 28;100(22):12666-71
Proceedings of the National Academy of Sciences of the United States of America 2003 Oct 28;100(22):12666-71
Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr.
Kino T, Tsukamoto M, Chrousos G
Biochemical and biophysical research communications 2002 Oct 18;298(1):17-23
Biochemical and biophysical research communications 2002 Oct 18;298(1):17-23
The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H.
Schneider E, Kartarius S, Schuster N, Montenarh M
Oncogene 2002 Aug 1;21(33):5031-7
Oncogene 2002 Aug 1;21(33):5031-7
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.
Zhou M, Halanski MA, Radonovich MF, Kashanchi F, Peng J, Price DH, Brady JN
Molecular and cellular biology 2000 Jul;20(14):5077-86
Molecular and cellular biology 2000 Jul;20(14):5077-86
Cell cycle-dependent stimulation of the HIV-1 promoter by Tat-associated CAK activator.
Nekhai S, Shukla RR, Fernandez A, Kumar A, Lamb NJ
Virology 2000 Jan 20;266(2):246-56
Virology 2000 Jan 20;266(2):246-56
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