Ab122157

antibody from Aladdin Scientific
Targeting: PKN1 DBK, MGC46204, PAK1, PKN, PRK1, PRKCL1
Provider product page for Ab122157

Antibody data

Product number
Ab122157 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant PKN1 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human PKN1 Antibody, Recombinant, could be used for WB and so on.Application:WB: 1/500-1/1000Protein FunctionPKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 900-913
Vial size
100_l,10_l,1ml,50_l
Concentration
0,2 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
PKN1 protein structure - Ab122157 shown in red.