Antibody data
- Antibody Data
- Antigen structure
- References [68]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 15112-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15112-1-AP, RRID:AB_2070016
- Product name
- CAPRIN1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CAPRIN1 antibody (Cat. #15112-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Stress Granule Core Protein-Derived Peptides Inhibit Assembly of Stress Granules and Improve Sorafenib Sensitivity in Cancer Cells.
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome.
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human.
Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress.
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Cell cycle associated protein 1 associates with immune infiltration and ferroptosis in gastrointestinal cancer.
SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer.
CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes.
Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.
Fear extinction is regulated by the activity of long noncoding RNAs at the synapse.
Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases.
circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR.
The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.
Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules.
Expression of GADD45G and CAPRIN1 in Human Nucleus Pulposus: Implications for Intervertebral Disc Degeneration.
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition.
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP.
The SARS-CoV-2 nucleocapsid protein suppresses innate immunity by remodeling stress granules to atypical foci.
Mitochondrial Inhibition by Sodium Azide Induces Assembly of eIF2α Phosphorylation-Independent Stress Granules in Mammalian Cells.
The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b.
Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells.
Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.
RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.
De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders.
High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate.
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.
Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms.
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
SNHG9 was upregulated in NSCLC and associated with DDP-resistance and poor prognosis of NSCLC patients.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
miR-193a/b-3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells.
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA.
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity.
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.
Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity.
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches.
Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis.
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.
Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.
Methods for the characterization of stress granules in virus infected cells.
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget.
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
UVC-induced stress granules in mammalian cells.
Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication.
CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.
Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.
Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.
Formation of antiviral cytoplasmic granules during orthopoxvirus infection.
Angiogenin-induced tRNA fragments inhibit translation initiation.
OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.
Li J, Zhang Y, Gu J, Zhou Y, Liu J, Cui H, Zhao T, Jin Z
Molecules (Basel, Switzerland) 2024 May 4;29(9)
Molecules (Basel, Switzerland) 2024 May 4;29(9)
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Clary JE, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvarado RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP
Cell reports 2024 Mar 26;43(3):113965
Cell reports 2024 Mar 26;43(3):113965
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome.
Barrow ER, Valionyte E, Baxter CR, Yang Y, Herath S, O'Connell WA, Lopatecka J, Strachan A, Woznica W, Stephenson HN, Fejer G, Sharma V, Lu B, Luo S
Cell reports 2024 Mar 26;43(3):113935
Cell reports 2024 Mar 26;43(3):113935
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human.
Huang W, Xiong T, Zhao Y, Heng J, Han G, Wang P, Zhao Z, Shi M, Li J, Wang J, Wu Y, Liu F, Xi JJ, Wang Y, Zhang QC
Nature genetics 2024 Jan;56(1):124-135
Nature genetics 2024 Jan;56(1):124-135
Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress.
Liboy-Lugo JM, Espinoza CA, Sheu-Gruttadauria J, Park JE, Xu A, Jowhar Z, Gao AL, Carmona-Negrón JA, Wittmann T, Jura N, Floor SN
bioRxiv : the preprint server for biology 2024 Feb 7;
bioRxiv : the preprint server for biology 2024 Feb 7;
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769
Cell reports 2024 Feb 27;43(2):113769
Cell cycle associated protein 1 associates with immune infiltration and ferroptosis in gastrointestinal cancer.
Gao Y, Wu R, Pei Z, Ke C, Zeng D, Li X, Zhang Y
Heliyon 2024 Apr 15;10(7):e28794
Heliyon 2024 Apr 15;10(7):e28794
SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer.
Zhao YQ, Jin HR, Kim D, Jung SH, Liu S, Wan J, Lo HY, Fu XQ, Wang Q, Hao C, Bellail AC
Molecular carcinogenesis 2023 Sep;62(9):1249-1262
Molecular carcinogenesis 2023 Sep;62(9):1249-1262
CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes.
Zheng Y, Li X, Deng S, Zhao H, Ye Y, Zhang S, Huang X, Bai R, Zhuang L, Zhou Q, Li M, Su J, Li R, Bao X, Zeng L, Chen R, Zheng J, Lin D, He C, Zhang J, Zuo Z
Nature communications 2023 Oct 10;14(1):6334
Nature communications 2023 Oct 10;14(1):6334
Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.
Hu S, Zhang Y, Yi Q, Yang C, Liu Y, Bai Y
Nature communications 2023 Nov 27;14(1):7782
Nature communications 2023 Nov 27;14(1):7782
Fear extinction is regulated by the activity of long noncoding RNAs at the synapse.
Liau WS, Zhao Q, Bademosi A, Gormal RS, Gong H, Marshall PR, Periyakaruppiah A, Madugalle SU, Zajaczkowski EL, Leighton LJ, Ren H, Musgrove M, Davies J, Rauch S, He C, Dickinson BC, Li X, Wei W, Meunier FA, Fernández-Moya SM, Kiebler MA, Srinivasan B, Banerjee S, Clark M, Spitale RC, Bredy TW
Nature communications 2023 Nov 22;14(1):7616
Nature communications 2023 Nov 22;14(1):7616
Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases.
Fujikawa D, Nakamura T, Yoshioka D, Li Z, Moriizumi H, Taguchi M, Tokai-Nishizumi N, Kozuka-Hata H, Oyama M, Takekawa M
Current biology : CB 2023 May 22;33(10):1967-1981.e8
Current biology : CB 2023 May 22;33(10):1967-1981.e8
circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR.
Liu J, Niu L, Hao J, Yao Y, Yan M, Li H
Oncogene 2023 Mar;42(13):980-993
Oncogene 2023 Mar;42(13):980-993
The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.
Curdy N, Lanvin O, Cerapio JP, Pont F, Tosolini M, Sarot E, Valle C, Saint-Laurent N, Lhuillier E, Laurent C, Fournié JJ, Franchini DM
Cell reports 2023 Mar 28;42(3):112211
Cell reports 2023 Mar 28;42(3):112211
Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules.
McGoldrick P, Lau A, You Z, Durcan TM, Robertson J
Cell reports 2023 Mar 28;42(3):112134
Cell reports 2023 Mar 28;42(3):112134
Expression of GADD45G and CAPRIN1 in Human Nucleus Pulposus: Implications for Intervertebral Disc Degeneration.
Kawaguchi K, Akeda K, Yamada J, Hasegawa T, Takegami N, Fujiwara T, Sudo A
International journal of molecular sciences 2023 Mar 17;24(6)
International journal of molecular sciences 2023 Mar 17;24(6)
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvardo RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP
bioRxiv : the preprint server for biology 2023 Jun 30;
bioRxiv : the preprint server for biology 2023 Jun 30;
The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition.
Martin JL, Terry SJ, Gale JE, Dawson SJ
Journal of cell science 2023 Jul 15;136(14)
Journal of cell science 2023 Jul 15;136(14)
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Dubinski A, Gagné M, Peyrard S, Gordon D, Talbot K, Vande Velde C
Human molecular genetics 2023 Jan 6;32(2):319-332
Human molecular genetics 2023 Jan 6;32(2):319-332
Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP.
Gao Y, Yuan L, Ke C, Pei Z, Liu X, Wu R, Kui X, Zhang Y
Journal of translational medicine 2023 Feb 28;21(1):159
Journal of translational medicine 2023 Feb 28;21(1):159
The SARS-CoV-2 nucleocapsid protein suppresses innate immunity by remodeling stress granules to atypical foci.
He S, Gou H, Zhou Y, Wu C, Ren X, Wu X, Guan G, Jin B, Huang J, Jin Z, Zhao T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23269
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23269
Mitochondrial Inhibition by Sodium Azide Induces Assembly of eIF2α Phosphorylation-Independent Stress Granules in Mammalian Cells.
Eiermann N, Stoecklin G, Jovanovic B
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b.
Lee YZ, Hsu HY, Yang CW, Lin YL, Chang SY, Yang RB, Liang JJ, Chao TL, Liao CC, Kao HC, Chang JY, Sytwu HK, Chen CT, Lee SJ
Pharmaceutics 2022 Jul 21;14(7)
Pharmaceutics 2022 Jul 21;14(7)
Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells.
Bayazit MB, Jacovetti C, Cosentino C, Sobel J, Wu K, Brozzi F, Rodriguez-Trejo A, Stoll L, Guay C, Regazzi R
Cell reports 2022 Jul 12;40(2):111069
Cell reports 2022 Jul 12;40(2):111069
Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.
Sheehan CT, Hampton TH, Madden DR
The Journal of biological chemistry 2022 Dec;298(12):102552
The Journal of biological chemistry 2022 Dec;298(12):102552
RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.
Viegas JO, Azad GK, Lv Y, Fishman L, Paltiel T, Pattabiraman S, Park JE, Kaganovich D, Sze SK, Rabani M, Esteban MA, Meshorer E
Developmental cell 2022 Dec 19;57(24):2731-2744.e5
Developmental cell 2022 Dec 19;57(24):2731-2744.e5
De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders.
Jia X, Zhang S, Tan S, Du B, He M, Qin H, Chen J, Duan X, Luo J, Chen F, Ouyang L, Wang J, Chen G, Yu B, Zhang G, Zhang Z, Lyu Y, Huang Y, Jiao J, Chen JYH, Swoboda KJ, Agolini E, Novelli A, Leoni C, Zampino G, Cappuccio G, Brunetti-Pierri N, Gerard B, Ginglinger E, Richer J, McMillan H, White-Brown A, Hoekzema K, Bernier RA, Kurtz-Nelson EC, Earl RK, Meddens C, Alders M, Fuchs M, Caumes R, Brunelle P, Smol T, Kuehl R, Day-Salvatore DL, Monaghan KG, Morrow MM, Eichler EE, Hu Z, Yuan L, Tan J, Xia K, Shen Y, Guo H
Science advances 2022 Aug 19;8(33):eabo7112
Science advances 2022 Aug 19;8(33):eabo7112
High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate.
Freibaum BD, Messing J, Yang P, Kim HJ, Taylor JP
The Journal of cell biology 2021 Mar 1;220(3)
The Journal of cell biology 2021 Mar 1;220(3)
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.
Vu L, Ghosh A, Tran C, Tebung WA, Sidibé H, Garcia-Mansfield K, David-Dirgo V, Sharma R, Pirrotte P, Bowser R, Vande Velde C
Journal of proteome research 2021 Jun 4;20(6):3165-3178
Journal of proteome research 2021 Jun 4;20(6):3165-3178
Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms.
Reuper H, Götte B, Williams L, Tan TJC, McInerney GM, Panas MD, Krenz B
International journal of molecular sciences 2021 Jun 11;22(12)
International journal of molecular sciences 2021 Jun 11;22(12)
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
Sun L, Li P, Ju X, Rao J, Huang W, Ren L, Zhang S, Xiong T, Xu K, Zhou X, Gong M, Miska E, Ding Q, Wang J, Zhang QC
Cell 2021 Apr 1;184(7):1865-1883.e20
Cell 2021 Apr 1;184(7):1865-1883.e20
SNHG9 was upregulated in NSCLC and associated with DDP-resistance and poor prognosis of NSCLC patients.
Wang R, Chen C, Kang W, Meng G
American journal of translational research 2020;12(8):4456-4466
American journal of translational research 2020;12(8):4456-4466
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.
García-Palmero I, Shah N, Ali NA, Daly RJ, Wilce JA, Villalobo A
Archives of biochemistry and biophysics 2020 Jul 15;687:108386
Archives of biochemistry and biophysics 2020 Jul 15;687:108386
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, Potts PR
Molecular cell 2020 Aug 20;79(4):645-659.e9
Molecular cell 2020 Aug 20;79(4):645-659.e9
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28
Cell 2020 Apr 16;181(2):325-345.e28
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP
Cell 2020 Apr 16;181(2):306-324.e28
Cell 2020 Apr 16;181(2):306-324.e28
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW
Neuron 2019 Sep 4;103(5):802-819.e11
Neuron 2019 Sep 4;103(5):802-819.e11
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
Gal J, Chen J, Na DY, Tichacek L, Barnett KR, Zhu H
Molecular and cellular biology 2019 Nov 15;39(22)
Molecular and cellular biology 2019 Nov 15;39(22)
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM, Pruett-Miller SM, Bertorini T, Vogel P, Kim HJ, Peng J, Taylor JP, Kundu M
Molecular cell 2019 May 16;74(4):742-757.e8
Molecular cell 2019 May 16;74(4):742-757.e8
miR-193a/b-3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells.
Ju B, Nie Y, Yang X, Wang X, Li F, Wang M, Wang C, Zhang H
Journal of cellular and molecular medicine 2019 Jun;23(6):3824-3832
Journal of cellular and molecular medicine 2019 Jun;23(6):3824-3832
Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA.
Xu H, Jiang Y, Xu X, Su X, Liu Y, Ma Y, Zhao Y, Shen Z, Huang B, Cao X
Nature immunology 2019 Dec;20(12):1621-1630
Nature immunology 2019 Dec;20(12):1621-1630
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity.
Gonçalves AC, Towers ER, Haq N, Porco JA Jr, Pelletier J, Dawson SJ, Gale JE
Scientific reports 2019 Aug 29;9(1):12501
Scientific reports 2019 Aug 29;9(1):12501
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Khalfallah Y, Kuta R, Grasmuck C, Prat A, Durham HD, Vande Velde C
Scientific reports 2018 May 15;8(1):7551
Scientific reports 2018 May 15;8(1):7551
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
Kuliyev E, Gingras S, Guy CS, Howell S, Vogel P, Pelletier S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Mar 7;38(10):2615-2630
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Mar 7;38(10):2615-2630
Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.
Liao KC, Chuo V, Ng WC, Neo SP, Pompon J, Gunaratne J, Ooi EE, Garcia-Blanco MA
RNA (New York, N.Y.) 2018 Jun;24(6):803-814
RNA (New York, N.Y.) 2018 Jun;24(6):803-814
Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.
Choudhury P, Bussiere LD, Miller CL
Journal of virology 2017 Nov 1;91(21)
Journal of virology 2017 Nov 1;91(21)
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity.
Yang CW, Lee YZ, Hsu HY, Shih C, Chao YS, Chang HY, Lee SJ
Scientific reports 2017 Jun 22;7(1):4105
Scientific reports 2017 Jun 22;7(1):4105
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Basu M, Courtney SC, Brinton MA
PLoS pathogens 2017 Feb;13(2):e1006240
PLoS pathogens 2017 Feb;13(2):e1006240
Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.
Kamelgarn M, Chen J, Kuang L, Arenas A, Zhai J, Zhu H, Gal J
Biochimica et biophysica acta 2016 Oct;1862(10):2004-14
Biochimica et biophysica acta 2016 Oct;1862(10):2004-14
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P
The Journal of cell biology 2016 Mar 28;212(7):845-60
The Journal of cell biology 2016 Mar 28;212(7):845-60
The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches.
Mineo M, Ricklefs F, Rooj AK, Lyons SM, Ivanov P, Ansari KI, Nakano I, Chiocca EA, Godlewski J, Bronisz A
Cell reports 2016 Jun 14;15(11):2500-9
Cell reports 2016 Jun 14;15(11):2500-9
Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis.
Johnson ME, Grassetti AV, Taroni JN, Lyons SM, Schweppe D, Gordon JK, Spiera RF, Lafyatis R, Anderson PJ, Gerber SA, Whitfield ML
Arthritis research & therapy 2016 Jan 22;18:27
Arthritis research & therapy 2016 Jan 22;18:27
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.
Lyons SM, Achorn C, Kedersha NL, Anderson PJ, Ivanov P
Nucleic acids research 2016 Aug 19;44(14):6949-60
Nucleic acids research 2016 Aug 19;44(14):6949-60
Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.
Dash S, Dang CA, Beebe DC, Lachke SA
Developmental dynamics : an official publication of the American Association of Anatomists 2015 Oct;244(10):1313-27
Developmental dynamics : an official publication of the American Association of Anatomists 2015 Oct;244(10):1313-27
Methods for the characterization of stress granules in virus infected cells.
Panas MD, Kedersha N, McInerney GM
Methods (San Diego, Calif.) 2015 Nov 15;90:57-64
Methods (San Diego, Calif.) 2015 Nov 15;90:57-64
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget.
Qiu YQ, Yang CW, Lee YZ, Yang RB, Lee CH, Hsu HY, Chang CC, Lee SJ
Oncotarget 2015 Feb 10;6(4):2148-63
Oncotarget 2015 Feb 10;6(4):2148-63
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C
The Journal of cell biology 2015 Apr 13;209(1):73-84
The Journal of cell biology 2015 Apr 13;209(1):73-84
UVC-induced stress granules in mammalian cells.
Moutaoufik MT, El Fatimy R, Nassour H, Gareau C, Lang J, Tanguay RM, Mazroui R, Khandjian EW
PloS one 2014;9(11):e112742
PloS one 2014;9(11):e112742
Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication.
Rozelle DK, Filone CM, Kedersha N, Connor JH
Molecular and cellular biology 2014 Jun;34(11):2003-16
Molecular and cellular biology 2014 Jun;34(11):2003-16
CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C
Neuron 2013 Sep 18;79(6):1169-82
Neuron 2013 Sep 18;79(6):1169-82
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.
Simeoni F, Tasselli L, Tanaka S, Villanova L, Hayashi M, Kubota K, Isono F, Garcia BA, Michishita-Kioi E, Chua KF
Scientific reports 2013 Oct 30;3:3085
Scientific reports 2013 Oct 30;3:3085
Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.
Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, Matsuura Y
Journal of virology 2013 Jan;87(1):489-502
Journal of virology 2013 Jan;87(1):489-502
Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
El Fatimy R, Tremblay S, Dury AY, Solomon S, De Koninck P, Schrader JW, Khandjian EW
PloS one 2012;7(6):e39338
PloS one 2012;7(6):e39338
Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.
Drougat L, Olivier-Van Stichelen S, Mortuaire M, Foulquier F, Lacoste AS, Michalski JC, Lefebvre T, Vercoutter-Edouart AS
Biochimica et biophysica acta 2012 Dec;1820(12):1839-48
Biochimica et biophysica acta 2012 Dec;1820(12):1839-48
Formation of antiviral cytoplasmic granules during orthopoxvirus infection.
Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH
Journal of virology 2011 Feb;85(4):1581-93
Journal of virology 2011 Feb;85(4):1581-93
Angiogenin-induced tRNA fragments inhibit translation initiation.
Ivanov P, Emara MM, Villen J, Gygi SP, Anderson P
Molecular cell 2011 Aug 19;43(4):613-23
Molecular cell 2011 Aug 19;43(4):613-23
OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.
Wehner KA, Schütz S, Sarnow P
Molecular and cellular biology 2010 Apr;30(8):2006-16
Molecular and cellular biology 2010 Apr;30(8):2006-16
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CAPRIN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CAPRIN1. This antibody recognizes human,mouse,rat antigen. The CAPRIN1 antibody has been validated for the following applications: ELISA, IHC, IP, WB, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 15112-1-AP( CAPRIN1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CAPRIN1 (IP:15112-1-AP, 3ug; Detection:15112-1-AP 1:300) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 15112-1-AP(CAPRIN1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 15112-1-AP(CAPRIN1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue