V7510
antibody from NSJ Bioreagents
Targeting: MUC1
ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM
Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- V7510 - Provider product page
- Provider
- NSJ Bioreagents
- Product name
- MUC1 Antibody / Mucin-1
- Antibody type
- Monoclonal
- Description
- Protein G affinity chromatography
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- VU-4H5
- Vial size
- 20 µg, 100 µg (with BSA, sodium azide), 100 µg (without BSA, sodium azide), 7 ml (prediluted for IHC)
- Concentration
- 0.2 mg/ml, 1 mg/ml (BSA/azide free format), Prediluted (IHC only format)
- Storage
- Store the MUC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Submitted references Abnormally glycosylated MUC1 establishes a positive feedback circuit of inflammatory cytokines, mediated by NF-κB p65 and EzH2, in colitis-associated cancer.
p53 determines prognostic significance of the carbohydrate stem cell marker TF1 (CD176) in ovarian cancer.
Immunobiology and immunosurveillance in patients with intraductal papillary mucinous neoplasms (IPMNs), premalignant precursors of pancreatic adenocarcinomas.
Prognostic Significance of Mucin Antigen MUC1 in Various Human Epithelial Cancers: A Meta-Analysis.
Reversed polarity of the glandular epithelial cells in micropapillary carcinoma of the large intestine and the EMA/MUC1 immunostain.
Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a.
T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer.
Association of placental inflammation with fetomaternal hemorrhage and loss of placental mucin-1.
Using the allergic immune system to target cancer: activity of IgE antibodies specific for human CD20 and MUC1.
5-Aza-2'-deoxycytidine increases sialyl Lewis X on MUC1 by stimulating β-galactoside:α2,3-sialyltransferase 6 gene.
Inflammation driven by overexpression of the hypoglycosylated abnormal mucin 1 (MUC1) links inflammatory bowel disease and pancreatitis.
Non-glycosylated tandem repeats of MUC1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ECM) in vitro: potential role in metastasis.
MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only partly hypoglycosylated form.
Cascio S, Faylo JL, Sciurba JC, Xue J, Ranganathan S, Lohmueller JJ, Beatty PL, Finn OJ
Oncotarget 2017 Dec 1;8(62):105284-105298
Oncotarget 2017 Dec 1;8(62):105284-105298
p53 determines prognostic significance of the carbohydrate stem cell marker TF1 (CD176) in ovarian cancer.
Heublein S, Page SK, Mayr D, Ditsch N, Jeschke U
Journal of cancer research and clinical oncology 2016 Jun;142(6):1163-70
Journal of cancer research and clinical oncology 2016 Jun;142(6):1163-70
Immunobiology and immunosurveillance in patients with intraductal papillary mucinous neoplasms (IPMNs), premalignant precursors of pancreatic adenocarcinomas.
Beatty PL, van der Geest R, Hashash JG, Kimura T, Gutkin D, Brand RE, Finn OJ
Cancer immunology, immunotherapy : CII 2016 Jul;65(7):771-8
Cancer immunology, immunotherapy : CII 2016 Jul;65(7):771-8
Prognostic Significance of Mucin Antigen MUC1 in Various Human Epithelial Cancers: A Meta-Analysis.
Xu F, Liu F, Zhao H, An G, Feng G
Medicine 2015 Dec;94(50):e2286
Medicine 2015 Dec;94(50):e2286
Reversed polarity of the glandular epithelial cells in micropapillary carcinoma of the large intestine and the EMA/MUC1 immunostain.
Cserni G
Pathology 2014 Oct;46(6):527-32
Pathology 2014 Oct;46(6):527-32
Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a.
Chachadi VB, Ali MF, Cheng PW
PloS one 2013;8(2):e57416
PloS one 2013;8(2):e57416
T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer.
Bauer K, Nelius N, Reuschenbach M, Koch M, Weitz J, Steinert G, Kopitz J, Beckhove P, Tariverdian M, von Knebel Doeberitz M, Kloor M
Cancer immunology, immunotherapy : CII 2013 Jan;62(1):27-37
Cancer immunology, immunotherapy : CII 2013 Jan;62(1):27-37
Association of placental inflammation with fetomaternal hemorrhage and loss of placental mucin-1.
Scholz C, Hermann C, Kachler A, Kainer F, Friese K, Makrigiannakis A, Jeschke U
Archives of gynecology and obstetrics 2012 Mar;285(3):605-12
Archives of gynecology and obstetrics 2012 Mar;285(3):605-12
Using the allergic immune system to target cancer: activity of IgE antibodies specific for human CD20 and MUC1.
Teo PZ, Utz PJ, Mollick JA
Cancer immunology, immunotherapy : CII 2012 Dec;61(12):2295-309
Cancer immunology, immunotherapy : CII 2012 Dec;61(12):2295-309
5-Aza-2'-deoxycytidine increases sialyl Lewis X on MUC1 by stimulating β-galactoside:α2,3-sialyltransferase 6 gene.
Chachadi VB, Cheng H, Klinkebiel D, Christman JK, Cheng PW
The international journal of biochemistry & cell biology 2011 Apr;43(4):586-93
The international journal of biochemistry & cell biology 2011 Apr;43(4):586-93
Inflammation driven by overexpression of the hypoglycosylated abnormal mucin 1 (MUC1) links inflammatory bowel disease and pancreatitis.
Kadayakkara DK, Beatty PL, Turner MS, Janjic JM, Ahrens ET, Finn OJ
Pancreas 2010 May;39(4):510-5
Pancreas 2010 May;39(4):510-5
Non-glycosylated tandem repeats of MUC1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ECM) in vitro: potential role in metastasis.
Ciborowski P, Finn OJ
Clinical & experimental metastasis 2002;19(4):339-45
Clinical & experimental metastasis 2002;19(4):339-45
MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only partly hypoglycosylated form.
ten Berge RL, Snijdewint FG, von Mensdorff-Pouilly S, Poort-Keesom RJ, Oudejans JJ, Meijer JW, Willemze R, Hilgers J, Meijer CJ
Journal of clinical pathology 2001 Dec;54(12):933-9
Journal of clinical pathology 2001 Dec;54(12):933-9
No comments: Submit comment
Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- IHC testing of FFPE human colon carcinoma with MUC1 antibody (clone VU-4H5). HIER: requires steaming of sections in 10mM citrate buffer, pH 6, for 10-20 min and allow to cool before testing.
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- IHC testing of FFPE human lung carcinoma with MUC1 antibody (clone VU-4H5). HIER: requires steaming of sections in 10mM citrate buffer, pH 6, for 10-20 min and allow to cool before testing.