ADAMTS3

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 3

Protein family

Cancer-related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

4:q13.3 (72280969 - 72569221)

Ensembl ID

ENSG00000156140  (ver. 99.38)

Orthologs

Mouse Adamts3: ENSMUSG00000043635

UniProt

O15072

neXtProt

NX_O15072

Human splice variants
Mouse splice variants