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LearnPAB11276
antibody from Abnova Corporation
Targeting: THRA
AR7, EAR-7.1/EAR-7.2, ERBA, ERBA1, NR1A1, THRA1, THRA2, THRA3
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- PAB11276 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB11276, RRID:AB_1710437
- Product name
- THRA polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of THRA.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor.
Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.
Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function.
Ying H, Araki O, Furuya F, Kato Y, Cheng SY
Molecular and cellular biology 2007 Mar;27(6):2359-71
Molecular and cellular biology 2007 Mar;27(6):2359-71
Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.
Nascimento AS, Dias SM, Nunes FM, AparÃcio R, Ambrosio AL, Bleicher L, Figueira AC, Santos MA, de Oliveira Neto M, Fischer H, Togashi M, Craievich AF, Garratt RC, Baxter JD, Webb P, Polikarpov I
Journal of molecular biology 2006 Jul 14;360(3):586-98
Journal of molecular biology 2006 Jul 14;360(3):586-98
Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function.
Wan W, Farboud B, Privalsky ML
Molecular endocrinology (Baltimore, Md.) 2005 Jun;19(6):1529-42
Molecular endocrinology (Baltimore, Md.) 2005 Jun;19(6):1529-42
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Supportive validation
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- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot using THRA polyclonal antibody (Cat # PAB11276) shows detection of purified recombinant THRA (lane 1) and THRA present in a 293 cell lysate after transient transfection with THRA (lane 3).No staining is evident in lysates from mock-transfected 293 cells (lane 2).Endogenous THRA is not detected in mouse brain tissue lysate (lane 4).Nuclear extracts may be required to detect endogenous THRA as the protein localizes within the nucleus.The band at ~55 kDa, indicated by the arrowhead, corresponds to THRA.Personal communication, S. Cheng and H. Ying, NCI, Bethesda, MD.
