15056-1-AP

antibody from Proteintech Group

Targeting: NUPR1 COM1, p8

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

15056-1-AP

Provider

Proteintech Group

Product name

NUPR1 antibody

Antibody type

Polyclonal

Description

NUPR1 antibody (Cat. #15056-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion.

Zhao J, Liu X, He Y, Sun Q, Xue Z, Tang Z, Liu J, Wang J, Li C, Wang X, Yang N, Qiu C
Theranostics 2026;16(8):4427-4451

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NUPR1 and LCN2: Potential Therapeutic Targets for Colorectal Cancer Via Modulating Cell Viability, Migration, and Ferroptosis-Related Pathways.

Luo D, Luo X, Qian S, Liu J
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70809

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Nuclear protein 1 protects against neonatal hypoxic-ischemic encephalopathy by inhibiting neuronal ferroptosis by improving iron storage.

He X, Wei S, Fu Y, Li H, Zhang J, Liu L
In vitro cellular & developmental biology. Animal 2025 Sep;61(8):977-990

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Panx3 mediates ferroptosis via the AKT/mTOR signaling pathway in oral squamous cell carcinoma.

Li X, Zhao Y, Liu Y, Zhang CS, Xu ZY, Wang SR, Zhang TM, Zhang Y, Liang SX, Yan YB
Cellular signalling 2025 Oct;134:111908

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FTO facilitates colorectal cancer chemoresistance via regulation of NUPR1-dependent iron homeostasis.

Xu C, Shen T, Feng L, Wang L, Li S, Ding R, Geng Z, Fan M, Xiao T, Zheng J, Shen L, Qu X
Redox biology 2025 Jun;83:103647

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Platycodin D-mediated METTL16 downregulation promotes docetaxel treatment of prostate cancer by regulating ferroptosis.

Sun C, Sun X, Chen Y, Wu Y, Xiang C, Wu S
BMC cancer 2025 Jul 1;25(1):1042

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Single-cell atlas profiling revealed cellular characteristics and dynamic changes after PD-1 blockade therapy of brain metastases from laryngeal squamous cell carcinoma.

Zou Y, Duan H, Deng Z, Xiang R, Zhao J, Zhang Z, Hu W, Yang Y, Yan Z, Wen S, Liu Z, Zhang G, Mou Y, Li D, Jiang X
Molecular and cellular biochemistry 2025 Apr;480(4):2377-2400

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ATF4/NUPR1 axis promotes cancer cell survival and mediates immunosuppression in clear cell renal cell carcinoma.

Lu Y, Chen W, Xuan Y, Li X, Wu S, Wang H, Guo T, Wang C, Tian S, Li H, Lai D, Zhao W, Huang X, Zhao X, Wang B, Zhang X, Li H, Huang Y, Ma X
Discover oncology 2024 Oct 31;15(1):607

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Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress.

Cui Y, Yang G, Li H, Sun J, Liu X, Xia X
Biochemical and biophysical research communications 2024 Oct 20;730:150365

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Mechanistic study of NUPR1 in bladder cancer development through transcriptional regulation of CCR2.

Shi Z, Mi Y, Zhang L, Zhang W, Zhang W, Shi X, Gao S, Zuo L, Zhang L
Journal of cellular physiology 2024 Nov;239(11):e31412

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Resistance to FOXM1 inhibitors in breast cancer is accompanied by impeding ferroptosis and apoptotic cell death.

Kumar S, Ziegler Y, Plotner BN, Flatt KM, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS
Breast cancer research and treatment 2024 Nov;208(2):307-320

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ScRNA-seq and bulk RNA-seq identified NUPR1 as novel biomarkers related to CD4 + T cells infiltration for abdominal aortic aneurysm.

Zhou Z, Deng T, Liu S, Huang L, Wang K, Kan Q, He R, Yao C
Molecular biology reports 2024 Nov 7;51(1):1127

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NUPR1 modulates pulmonary embolism progression via smooth muscle cells phenotypic transformation.

Wang S, Xu A, Chen M, Wu Y
Heliyon 2024 Nov 15;10(21):e38918

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NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway.

Ren S, Chen Y, Wang Q, Song L, Xin Z, Shi M, Liu X
Pathology, research and practice 2024 May;257:155323

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CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis.

Zhang XY, Li SS, Gu YR, Xiao LX, Ma XY, Chen XR, Wang JL, Liao CH, Lin BL, Huang YH, Lian YF
Molecular cancer 2024 May 28;23(1):113

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Chronic nickel exposure alters extracellular vesicles to mediate cancer progression via sustained NUPR1 expression.

Liu S, Costa M, Ortiz A
Journal of inorganic biochemistry 2024 Mar;252:112477

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Integrated multi-omic analysis and experiment reveals the role of endoplasmic reticulum stress in lung adenocarcinoma.

Liu Y, Lin W, Qian H, Yang Y, Zhou X, Wu C, Pan X, Liu Y, Wang G
BMC medical genomics 2024 Jan 2;17(1):12

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WTAP Mediates NUPR1 Regulation of LCN2 Through m(6)A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion.

Tan M, He Y, Yi J, Chen J, Guo Q, Liao N, Peng L
Biochemical genetics 2024 Apr;62(2):876-891

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Nuclear Protein 1 Expression Is Associated with PPARG in Bladder Transitional Cell Carcinoma.

Lu C, Gao S, Zhang L, Shi X, Chen Y, Wei S, Zuo L, Zhang L
PPAR research 2023;2023:6797694

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[Mechanism of nuclear protein 1 in the resistance to axitinib in clear cell renal cell carcinoma].

Liu YC, Wu ZL, Ge LY, DU T, Wu YQ, Song YM, Liu C, Ma LL
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2023 Oct 18;55(5):781-792

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SETD4 inhibits prostate cancer development by promoting H3K27me3-mediated NUPR1 transcriptional repression and cell cycle arrest.

Wang C, Wang T, Li KJ, Hu LH, Li Y, Yu YZ, Xie T, Zhu S, Fu DJ, Wang Y, Zeng XZ, Liu FP, Chen H, Chen ZS, Feng NH, Liu J, Jiang Y, Zhao SC
Cancer letters 2023 Nov 28;579:216464

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NUPR1 imparts oncogenic potential in bladder cancer.

Zhang L, Gao S, Shi X, Chen Y, Wei S, Mi Y, Zuo L, Qi C
Cancer medicine 2023 Mar;12(6):7149-7163

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The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis.

Wang Y, Zhang Y, Wang Z, Yu L, Chen K, Xie Y, Liu Y, Liang W, Zheng Y, Zhan Y, Ding Y
Cell death discovery 2022 Oct 28;8(1):431

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NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.

Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, Li G, Liang L, Ding Y
BMC medicine 2022 Oct 19;20(1):365

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Adenomatous Polyposis Coli loss controls cell cycle regulators and response to paclitaxel in MDA-MB-157 metaplastic breast cancer cells.

Astarita EM, Maloney SM, Spring CA, Berkeley BJ, VanKlompenberg MK, Nair TM, Prosperi JR
PloS one 2021;16(8):e0255738