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Learnorb67253
antibody from Biorbyt
Targeting: TRIM33
FLJ11429, KIAA1113, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
Western blotAntibody data
- Antibody Data
- Antigen structure
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- Product number
- orb67253 - Provider product page
- Provider
- Biorbyt
- Product name
- TRIM33 antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal to TRIM33.Tripartite motif-containing protein 33 (TRIM33) is a nuclear protein localized in discrete nuclear dotsresembling nuclear bodies. TRIM33 acts as an E3 ubiquitin-protein ligase, and promotes SMAD4ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. TRIM33 mayact as a transcriptional repressor of the TGF-beta/BMP signaling cascade. It is thought that TRIM33can monoubiquitinate SMAD4, which hampers its ability to form a stable complex with activatedSMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. TRIM33 plays a role in thecontrol of cell proliferation. Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC).
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 100 ul
- Storage
- -20°C
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