HPA004820

antibody from Atlas Antibodies

Targeting: GRHL2 BOM, DFNA28, FLJ13782, TFCP2L3

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA004820

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA004820, RRID:AB_1857928

Product name

Anti-GRHL2

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human GRHL2, Gene description: grainyhead-like 2 (Drosophila), Alternative Gene Names: BOM, DFNA28, FLJ13782, TFCP2L3, Validated applications: IHC, Uniprot ID: Q6ISB3, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.3 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal Cancer

Murtough S, Babu D, Webb C, Louis dit Picard H, McGinty L, Chao-Chu J, Pink R, Silver A, Smart H, Field J, Woodland P, Risk J, Blaydon D, Pennington D, Kelsell D
Gastro Hep Advances 2024;3(3):385-395

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Elevated GRHL2 Imparts Plasticity in ER-Positive Breast Cancer Cells

Zheng C, Allen K, Liu T, Solodin N, Meyer M, Salem K, Tsourkas P, McIlwain S, Vera J, Cromwell E, Ozers M, Fowler A, Alarid E
Cancers 2024;16(16):2906

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Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse

de Vries M, Carpinelli M, Fuller J, Sutton Y, Partridge D, Auden A, Anderson P, Jane S, Dworkin S
Development 2024;151(5)

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GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment.

Coban B, Wang Z, Liao CY, Beslmüller K, Timmermans MAM, Martens JWM, Hundscheid JHM, Slutter B, Zweemer AJM, Neubert E, Danen EHJ
iScience 2024 May 17;27(5):109738

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GRHL2 Enhances Phosphorylated Estrogen Receptor (ER) Chromatin Binding and Regulates ER-Mediated Transcriptional Activation and Repression

Reese R, Helzer K, Allen K, Zheng C, Solodin N, Alarid E
Molecular and Cellular Biology 2023;42(10)

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The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2

Helzer K, Szatkowski Ozers M, Meyer M, Benkusky N, Solodin N, Reese R, Warren C, Pike J, Alarid E
Molecular and Cellular Biology 2023;39(3)

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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development

Collier A, Piekos S, Liu A, Pattison J, Felix F, Bailetti A, Sedov E, Gaddam S, Zhen H, Oro A
iScience 2023;26(3):106125

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GRHL2 Regulation of Growth/Motility Balance in Luminal versus Basal Breast Cancer.

Wang Z, Coban B, Liao CY, Chen YJ, Liu Q, Danen EHJ
International journal of molecular sciences 2023 Jan 28;24(3)

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GRHL2-controlled gene expression networks in luminal breast cancer.

Wang Z, Coban B, Wu H, Chouaref J, Daxinger L, Paulsen MT, Ljungman M, Smid M, Martens JWM, Danen EHJ
Cell communication and signaling : CCS 2023 Jan 23;21(1):15

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Cis-regulatory chromatin loops analysis identifies GRHL3 as a master regulator of surface epithelium commitment

Huang H, Liu J, Li M, Guo H, Zhu J, Zhu L, Wu S, Mo K, Huang Y, Tan J, Chen C, Wang B, Yu Y, Wang L, Liu Y, Ouyang H
Science Advances 2022;8(28)

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Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells

Gupta A, Sasse S, Berman R, Gruca M, Dowell R, Chu H, Downey G, Gerber A
Physiological Genomics 2022;54(10):389-401

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TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers

McIntyre A, Angel C, Smith J, Templeman A, Beattie K, Beattie S, Ormrod A, Devlin E, McGreevy C, Bothwell C, Eddie S, Buckley N, Williams R, Mullan P
Nucleic Acids Research 2022;50(11):6154-6173

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3D genome organization in the epithelial-mesenchymal transition spectrum

Pang Q, Tan T, Sundararajan V, Chiu Y, Chee E, Chung V, Choolani M, Huang R
Genome Biology 2022;23(1)

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Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma

Wang Q, Zhang Y, Zhang B, Fu Y, Zhao X, Zhang J, Zuo K, Xing Y, Jiang S, Qin Z, Li E, Guo H, Liu Z, Yang J
Nature Communications 2022;13(1)

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Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland

Matsuoka S, Suzuki H, Kato C, Kamikawa-Tokai M, Kamikawa A, Okamatsu-Ogura Y, Kimura K
Journal of Histochemistry & Cytochemistry 2021;69(6):373-388

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A modular master regulator landscape controls cancer transcriptional identity

Paull E, Aytes A, Jones S, Subramaniam P, Giorgi F, Douglass E, Tagore S, Chu B, Vasciaveo A, Zheng S, Verhaak R, Abate-Shen C, Alvarez M, Califano A
Cell 2021;184(2):334-351.e20

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Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer

Zhang Y, Chan H, Garcia-Martinez L, Karl D, Weich N, Slingerland J, Verdun R, Morey L
Science Advances 2020;6(23)

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Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

Carpinelli M, de Vries M, Auden A, Butt T, Deng Z, Partridge D, Miles L, Georgy S, Haigh J, Darido C, Brabletz S, Brabletz T, Stemmler M, Dworkin S, Jane S
Disease Models & Mechanisms 2020;13(3)

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The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer

Cocce K, Jasper J, Desautels T, Everett L, Wardell S, Westerling T, Baldi R, Wright T, Tavares K, Yllanes A, Bae Y, Blitzer J, Logsdon C, Rakiec D, Ruddy D, Jiang T, Broadwater G, Hyslop T, Hall A, Laine M, Phung L, Greene G, Martin L, Pancholi S, Dowsett M, Detre S, Marks J, Crawford G, Brown M, Norris J, Chang C, McDonnell D
Cell Reports 2019;29(4):889-903.e10

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VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Holding A, Giorgi F, Donnelly A, Cullen A, Nagarajan S, Selth L, Markowetz F
Genome Biology 2019;20(1)

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The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells

Chung V, Tan T, Ye J, Huang R, Lai H, Kappei D, Wollmann H, Guccione E, Huang R
Communications Biology 2019;2(1)

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Estrogen receptor signaling is reprogrammed during breast tumorigenesis

Chi D, Singhal H, Li L, Xiao T, Liu W, Pun M, Jeselsohn R, He H, Lim E, Vadhi R, Rao P, Long H, Garber J, Brown M
Proceedings of the National Academy of Sciences 2019;116(23):11437-11443

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Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers

MacFawn I, Wilson H, Selth L, Leighton I, Serebriiskii I, Bleackley R, Elzamzamy O, Farris J, Pifer P, Richer J, Frisch S
Molecular Immunology 2019;105

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Evaluation of 6-mercaptopurine in a cell culture model of adaptable triple-negative breast cancer with metastatic potential

Singh B, Sarli V, Kinne H, Shamsnia A, Lucci A
Oncotarget 2019;10(38):3681-3693

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Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2

Nikolopoulou E, Hirst C, Galea G, Venturini C, Moulding D, Marshall A, Rolo A, De Castro S, Copp A, Greene N
Nature Communications 2019;10(1)

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GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency

Chen A, Liu A, Krishnakumar R, Freimer J, DeVeale B, Blelloch R
Cell Stem Cell 2018;23(2):226-238.e4

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Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer

Paltoglou S, Das R, Townley S, Hickey T, Tarulli G, Coutinho I, Fernandes R, Hanson A, Denis I, Carroll J, Dehm S, Raj G, Plymate S, Tilley W, Selth L
Cancer Research 2017;77(13):3417-3430

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Grainyhead‐like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression

Nishino H, Takano S, Yoshitomi H, Suzuki K, Kagawa S, Shimazaki R, Shimizu H, Furukawa K, Miyazaki M, Ohtsuka M
Cancer Medicine 2017;6(11):2686-2696

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DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells

Pistore C, Giannoni E, Colangelo T, Rizzo F, Magnani E, Muccillo L, Giurato G, Mancini M, Rizzo S, Riccardi M, Sahnane N, Del Vescovo V, Kishore K, Mandruzzato M, Macchi F, Pelizzola M, Denti M, Furlan D, Weisz A, Colantuoni V, Chiarugi P, Bonapace I
Oncogene 2017;36(40):5551-5566

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GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification

Chung V, Tan T, Tan M, Wong M, Kuay K, Yang Z, Ye J, Muller J, Koh C, Guccione E, Thiery J, Huang R
Scientific Reports 2016;6(1)

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Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea

Hosoya M, Fujioka M, Ogawa K, Okano H
Scientific Reports 2016;6(1)

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FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3

Jozwik K, Chernukhin I, Serandour A, Nagarajan S, Carroll J
Cell Reports 2016;17(10):2715-2723

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Grainyhead-like 2 Promotes Tumor Growth and is Associated with Poor Prognosis in Colorectal Cancer

Quan Y, Xu M, Cui P, Ye M, Zhuang B, Min Z
Journal of Cancer 2015;6(4):342-350

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GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells

Gao X, Bali A, Randell S, Hogan B
Journal of Cell Biology 2015;211(3):669-682

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Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer.

Torres-Reyes LA, Alvarado-Ruiz L, Piña-Sánchez P, Martínez-Silva MG, Ramos-Solano M, Olimón-Andalón V, Ortiz-Lazareno PC, Hernández-Flores G, Bravo-Cuellar A, Aguilar-Lemarroy A, Jave-Suarez LF
International journal of clinical and experimental pathology 2014;7(11):7409-18

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Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1

Quan Y, Jin R, Huang A, Zhao H, Feng B, Zang L, Zheng M
Cancer Biology & Therapy 2014;15(7):878-887

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Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.

Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D
American journal of physiology. Lung cellular and molecular physiology 2014 Mar 1;306(5):L405-19

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Epithelial–Mesenchymal Transition and Tumor Suppression Are Controlled by a Reciprocal Feedback Loop between ZEB1 and Grainyhead-like-2

Cieply B, Farris J, Denvir J, Ford H, Frisch S
Cancer Research 2013;73(20):6299-6309

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Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium

Gao X, Vockley C, Pauli F, Newberry K, Xue Y, Randell S, Reddy T, Hogan B
Proceedings of the National Academy of Sciences 2013;110(23):9356-9361

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The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation

Varma S, Cao Y, Tagne J, Lakshminarayanan M, Li J, Friedman T, Morell R, Warburton D, Kotton D, Ramirez M
Journal of Biological Chemistry 2012;287(44):37282-37295