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Western blot
Immunocytochemistry
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- AMAb90549 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#AMAb90549, RRID:AB_2665583
- Product name
- Anti-FUS
- Antibody type
- Monoclonal
- Description
- Monoclonal Antibody against Human FUS, Clone ID: CL0190, Gene description: fused in sarcoma, Alternative Gene Names: ALS6, FUS1, hnRNP-P2, TLS, Validated applications: ICC, IHC, WB, Uniprot ID: P35637, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- CL0190
- Vial size
- 100 µl
- Concentration
- 1.0 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy
Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain-of-function toxicity mechanism contributing to the pathogenesis of fragile X-associated premature ovarian insufficiency.
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane-less RNP granules.
A method for Boolean analysis of protein interactions at a molecular level.
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
Castillo Bautista C, Eismann K, Gentzel M, Pelucchi S, Mertens J, Walters H, Yun M, Sterneckert J
Cells 2023;12(18):2247
Cells 2023;12(18):2247
Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain-of-function toxicity mechanism contributing to the pathogenesis of fragile X-associated premature ovarian insufficiency.
Rosario R, Stewart HL, Choudhury NR, Michlewski G, Charlet-Berguerand N, Anderson RA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22612
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22612
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane-less RNP granules.
Decker CJ, Burke JM, Mulvaney PK, Parker R
The EMBO journal 2022 May 2;41(9):e110137
The EMBO journal 2022 May 2;41(9):e110137
A method for Boolean analysis of protein interactions at a molecular level.
Raykova D, Kermpatsou D, Malmqvist T, Harrison PJ, Sander MR, Stiller C, Heldin J, Leino M, Ricardo S, Klemm A, David L, Spjuth O, Vemuri K, Dimberg A, Sundqvist A, Norlin M, Klaesson A, Kampf C, Söderberg O
Nature communications 2022 Aug 13;13(1):4755
Nature communications 2022 Aug 13;13(1):4755
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
Marrone L, Drexler H, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson E, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard T, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey U, Hyman A, Alberti S, Goswami A, Sterneckert J
Acta Neuropathologica 2019;138(1):67-84
Acta Neuropathologica 2019;138(1):67-84
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-FUS antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human cerebral cortex and liver tissues using AMAb90549 antibody. Corresponding FUS RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
