Antibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [6]
Submit
Validation data
Reference
Comment
Report error
- Product number
- HPA008784 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA008784, RRID:AB_1849181
- Product name
- Anti-FUS
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSS
SYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGY
GQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGS
GGGYGNQDQSGGGGSGGYGQQDR- Isotype
- IgG
- Vial size
- 100 µl
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Submitted references Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia.
Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies.
Distribution and Pattern of Pathology in Subjects with Familial or Sporadic Late-Onset Cerebellar Ataxia as Assessed by p62/Sequestosome Immunohistochemistry
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.
Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.
FUS pathology in basophilic inclusion body disease
A new subtype of frontotemporal lobar degeneration with FUS pathology.
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.
Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S
Proceedings of the National Academy of Sciences of the United States of America 2015 Jun 23;112(25):7821-6
Proceedings of the National Academy of Sciences of the United States of America 2015 Jun 23;112(25):7821-6
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia.
Ziskin JL, Greicius MD, Zhu W, Okumu AN, Adams CM, Plowey ED
Acta neuropathologica communications 2015 Jul 10;3:43
Acta neuropathologica communications 2015 Jul 10;3:43
Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.
Nakamura M, Murray ME, Lin WL, Kusaka H, Dickson DW
American journal of neurodegenerative disease 2014;3(2):93-102
American journal of neurodegenerative disease 2014;3(2):93-102
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Sephton CF, Tang AA, Kulkarni A, West J, Brooks M, Stubblefield JJ, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G
Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 4;111(44):E4769-78
Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 4;111(44):E4769-78
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ
The Journal of clinical investigation 2014 Mar;124(3):981-99
The Journal of clinical investigation 2014 Mar;124(3):981-99
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R
Acta neuropathologica communications 2014 Dec 10;2:172
Acta neuropathologica communications 2014 Dec 10;2:172
Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
Dobson-Stone C, Luty AA, Thompson EM, Blumbergs P, Brooks WS, Short CL, Field CD, Panegyres PK, Hecker J, Solski JA, Blair IP, Fullerton JM, Halliday GM, Schofield PR, Kwok JB
Acta neuropathologica 2013 Apr;125(4):523-33
Acta neuropathologica 2013 Apr;125(4):523-33
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
Dormann D, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C
The EMBO journal 2012 Nov 14;31(22):4258-75
The EMBO journal 2012 Nov 14;31(22):4258-75
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
Snowden J, Rollinson S, Thompson J, Harris J, Stopford C, Richardson A, Jones M, Gerhard A, Davidson Y, Robinson A, Gibbons L, Hu Q, DuPlessis D, Neary D, Mann D, Pickering-Brown S
Brain 2012 February;135(3):693-708
Brain 2012 February;135(3):693-708
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR
Brain : a journal of neurology 2011 Sep;134(Pt 9):2595-609
Brain : a journal of neurology 2011 Sep;134(Pt 9):2595-609
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies.
Lashley T, Rohrer JD, Bandopadhyay R, Fry C, Ahmed Z, Isaacs AM, Brelstaff JH, Borroni B, Warren JD, Troakes C, King A, Al-Saraj S, Newcombe J, Quinn N, Ostergaard K, Schrøder HD, Bojsen-Møller M, Braendgaard H, Fox NC, Rossor MN, Lees AJ, Holton JL, Revesz T
Brain : a journal of neurology 2011 Sep;134(Pt 9):2548-64
Brain : a journal of neurology 2011 Sep;134(Pt 9):2548-64
Distribution and Pattern of Pathology in Subjects with Familial or Sporadic Late-Onset Cerebellar Ataxia as Assessed by p62/Sequestosome Immunohistochemistry
Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I
The Cerebellum 2011 December;10(4):720-731
The Cerebellum 2011 December;10(4):720-731
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.
Kino Y, Washizu C, Aquilanti E, Okuno M, Kurosawa M, Yamada M, Doi H, Nukina N
Nucleic acids research 2011 Apr;39(7):2781-98
Nucleic acids research 2011 Apr;39(7):2781-98
Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration
Seelaar H, Klijnsma K, de Koning I, van der Lugt A, Chiu W, Azmani A, Rozemuller A, van Swieten J
Journal of Neurology 2010 May;257(5):747-753
Journal of Neurology 2010 May;257(5):747-753
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T
Annals of neurology 2010 Jun;67(6):739-48
Annals of neurology 2010 Jun;67(6):739-48
FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.
Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, FReJA Consortium, Dickson DW, Rademakers R, Graff-Radford NR, Parisi JE, Petersen RC, Hatanpaa KJ, White CL 3rd, Weiner MF, Geser F, Van Deerlin VM, Trojanowski JQ, Miller BL, Seeley WW, van der Zee J, Kumar-Singh S, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bigio EH, Deng HX, Halliday GM, Kril JJ, Munoz DG, Mann DM, Pickering-Brown SM, Doodeman V, Adamson G, Ghazi-Noori S, Fisher EM, Holton JL, Revesz T, Rossor MN, Collinge J, Mead S, Isaacs AM
Acta neuropathologica 2010 Jul;120(1):33-41
Acta neuropathologica 2010 Jul;120(1):33-41
FUS pathology in basophilic inclusion body disease
Munoz D, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie I
Acta Neuropathologica 2009 November;118(5):617-627
Acta Neuropathologica 2009 November;118(5):617-627
A new subtype of frontotemporal lobar degeneration with FUS pathology.
Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR
Brain : a journal of neurology 2009 Nov;132(Pt 11):2922-31
Brain : a journal of neurology 2009 Nov;132(Pt 11):2922-31
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.
Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR
Acta neuropathologica 2009 Nov;118(5):605-16
Acta neuropathologica 2009 Nov;118(5):605-16
No comments: Submit comment
Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-FUS antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
- Sample type
- HUMAN
Enhanced validation
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human endometrium and liver tissues using HPA008784 antibody. Corresponding FUS RNA-seq data are presented for the same tissues.
- Sample type
- HUMAN
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human endometrium shows strong nuclear positivity in glandular cells and stromal cells.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human testis shows strong nuclear positivity in cells in seminiferous ducts.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human colon shows strong nuclear positivity in glandular cells.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human cerebellum shows strong nuclear positivity in neuronal cells.
- Sample type
- HUMAN
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human liver shows moderate nuclear positivity in bile duct cells while hepatocytes are negative.
- Sample type
- HUMAN