28212-1-AP

antibody from Proteintech Group

Targeting: SREBF2 bHLHd2, SREBP2

Provider product page for 28212-1-AP

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
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Product number: 28212-1-AP - Provider product page
Provider: Proteintech Group
Product name: SREBF2 antibody
Antibody type: Polyclonal
Description: KD/KO validated SREBF2 antibody (Cat. #28212-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SREBF2 protein structure - 28212-1-AP shown in red.

Submitted references Iron overload reprogramming lipid metabolism through the IRP1-SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis.

Liu Y, Fang L, Wang M, Zhong S, Xiong Y, Hou Y, Ren J, Li Y, Zhu W, Meng X, Lu C, Pan Y
Experimental & molecular medicine 2026 May 1;

Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.

Wang J, Liu WW, Huang QL, Ning HJ, Wang JY, Han XH
Acta pharmacologica Sinica 2026 Mar;47(3):735-749

SREBP2-RAB11A-ZDHHC20 axis orchestrates FGFR3 palmitoylation and membrane retention to drive bladder cancer progression.

Zhang WW, Qu HR, Du XS, Sun SJ, Chen PR, Deng ZH, Pan Q, Luo FL, Wu HY, Song C, Liu M
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 26;49(1):30

CCL14, identified by multi-omics approach, serves as a novel indicator of disease severity and progression in lymphangioleiomyomatosis.

Bai W, Hua L, Wang X, Guo M, Chen L, Liu B, Wang Y, Zhou Y, Wang Q, Zhang N, Xie M
Orphanet journal of rare diseases 2026 Jan 20;21(1):59

SREBP2 confers ferroptosis resistance by targeting GPX4 in colorectal cancer.

Zhong H, Chen R, Chen T, Lin M, Wen S, Zhang M, Liu D, Yu J, Chen J, Yi B, Liang R, Jiang W, Li Z
Apoptosis : an international journal on programmed cell death 2026 Jan 10;31(1):30

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development.

Tong J, Wang D, Song H, Sun T, Zhao Y, Gu W, Lin L, Zhao Y, Liang Y, Jin X, Fu R, Ju M, Gao J, Ma J, Gao C, Zhang A, Xiao Z, Jiang E, Yang R, Ma S, Zhang L, Shi L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e05249

Baicalein alleviates hepatic lipid metabolism disorders via the PPARα-FGF21-adiponectin axis: Regulating crosstalk between the liver and adipose tissue.

Xia QS, Chen Y, Shen P, Gong J, Lu FE, Chen H
Journal of ethnopharmacology 2026 Aug 10;367:121676

FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.

Wang M, Ge F, Wu C, Su B, Dong X, Xu S, Shi H
Frontiers in immunology 2025;16:1611375

Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet.

Ma J, Gong Z, Lu H, Yang H, Wang S, Zhu Q, Liu H, Li Y, Zhang Y, Lian X
Frontiers in nutrition 2025;12:1649407

Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma.

Wang JY, Chen MP, Jiang JX, Wan YK, Li X, Zhang YW, Fang Y, Huang HH, Qin ZY, Hou J
Acta pharmacologica Sinica 2025 Sep;46(9):2496-2508

Timosaponin A3 Ameliorates Prostate Cancer Progression via Upregulating STARD4 Mediated Cholesterol Metabolism.

Zhi Y, Ge L, Wang S, Zang W, Zhang Z, Xu T, Zhang Y, Song F, Huang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 30;39(18):e71063

RPL6 Interacts with HMGCS1 to Stabilize HIF-1α by Promoting Cholesterol Production in Hepatocellular Carcinoma.

Yang M, Cheng S, Gu H, Zhong S, Zhang D, He X, Chen W, Deng H, Ren J, Chen P, Tan M, Zhang H, Li F, Zhang Z, Hu Y, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e01373

SENP3 Promotes Hepatocyte Steatosis via De-SUMOylation of SREBP2.

Tang Q, Peng W, Jiang X, Hu Y, Chen L, Fu N
Cell biochemistry and function 2025 Nov;43(11):e70141

Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.

Hu HM, Deng JL, Pan Y, Wang ZH, Zhang J, Yu Gu X, Fan SX, Zhao JZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387

Malignant Hepatoblast-Like Cells Sustain Stemness via IGF2-Dependent Cholesterol Accumulation in Hepatoblastoma.

Ding M, Mao S, Wu H, Fang S, Zhen N, Chen T, Zhu J, Tang X, Wang X, Sun F, Zhu G, Pan Q, Ma J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2407671

Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfusion injury.

Liu Z, Zhao Z, Xiao Z, Li M, Wang X, Huang Y, Li Y
Cell death discovery 2025 May 7;11(1):223

APOL4-mediated intracellular cholesterol trafficking is essential for glioblastoma cell growth.

Zhang M, Yang T, Qian Y
BMC cancer 2025 May 21;25(1):906

A high cholesterol diet aggravates experimental colitis through SREBP2-modulated endocytosis and degradation of occludin and Zo-1 proteins.

Yang Q, Li Y, Wang X, Ding Q, Tao Y, Li P, Lian X, Chen Y, Zhao L
The FEBS journal 2025 Mar;292(5):1052-1069

A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis.

Roussis IM, Pearton DJ, Niazi U, Tsaknakis G, Papadopoulos GL, Cook R, Saqi M, Ragoussis J, Strouboulis J
PLoS genetics 2025 Mar;21(3):e1011617

Lipid-lowering effects of bile Arisaema polysaccharides on high-fat diet-induced hyperlipidemia: An integrated analysis of metabolomics, lipidomics and microbiome.

Su FZ, Bai CX, Zhang WS, Liu M, Li B, Sun MH, He YJ, Zeng YN, Sun YP, Yang BY, Kuang HX, Wang QH
International journal of biological macromolecules 2025 Jun;311(Pt 4):143932

Timosaponin AⅢ inhibits ectopic lipid deposition and enhances the browning of white adipose tissue.

Zhao W, Wang X, Liu Y, Lu L, Ding Y, Zhang T
European journal of pharmacology 2025 Jul 5;998:177506

Effects of Paeoniae Radix Rubra on lowering lipid via bioinformatics and gut microbiome.

Lin Z, Luo H, Pan S, Li Y, Zhou X, Zhao J, Xu X, Li X, Wang Y, Lv G, Lin Z, Lin H, Qi W
Scientific reports 2025 Jul 1;15(1):21117

Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.

Li Y, Li F, Shu J, Meng C, Zhang J, Zhang J, Qian Y, Wang H, Ding Q, Cao S
Animal reproduction science 2025 Jan;272:107649

The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.

Zhang JL, Wang XF, Li JL, Duan C, Wang JF
Veterinary research 2025 Jan 31;56(1):23

Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.

Kamchonemenukool S, Koh YC, Ho PY, Pan MH, Weerawatanakorn M
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442

Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer.

Chen J, Cui H, Wang X, Zeng Y, Pan D, Chen J, Zhang Z, An Y, Gu Z, Cai G, Wang H, Yu M, Yang B, Zhou S, Tan J, Liu L, Wang J, Li J, Han F
Journal of translational medicine 2025 Dec 9;23(1):1390

The SREBF2-ACOT7 axis promotes tumor progression and predicts prognosis in diffuse large b-cell lymphoma.

Wang H, Yao X, Wu S, Heng J, Cheng Y, Li L
Scientific reports 2025 Dec 7;15(1):43505

Cellular cholesterol metabolism rewiring through SREBP2-LXR-mTOR signaling convergence orchestrates T cell fate and keratinocyte apoptosis in oral lichen planus.

Jiang Q, Tang YX, Zhou G
International immunopharmacology 2025 Dec 3;166:115457

SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.

Li B, Zhou K, Yin A, Liu Y, Wang X, Cui Y, Liu F, Liu Q, Zheng H, Mu Z, Chen K, Wu Y, Chang Y, Bao J
Nature communications 2025 Dec 26;17(1):835

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL.

Mandleywala K, Ulrich S, da Silva-Diz V, Sharma P, Thai C, Kim O, Aleksandrova M, Chung G, Eggers C, Lütjohann D, Kulkarni T, Singh A, Elena Díaz-Rubio M, Wierer M, Leidel SA, Su X, White EP, Rabinowitz JD, Morscher RJ, Herranz D
bioRxiv : the preprint server for biology 2025 Dec 23;

A cholesterol-responsive hepatic tRNA-derived small RNA regulates cholesterol homeostasis and atherosclerosis development.

Li X, Hernandez R, Zhang X, Tang S, Yuan X, Wu J, Pham K, Rawal HC, Heinrich EC, Zhang S, Chen Q, Zhou T, Zhou C
Nature communications 2025 Dec 15;16(1):11043

Let-7f-5p Inhibits PRRSV Replication by Regulating Lipid Metabolic Reprogramming in Infected Cells.

Jiang D, Huang J, Wang X, Zhao G, Li C, Yang L, Meng X, Xu Q
Veterinary sciences 2025 Dec 10;12(12)

Tumor necrosis factor alpha-induced activation of SREBP2 promotes cholesterol biosynthesis in cholestasis.

Xu Z, Cao X, Zhu Z, Lei J, Li L, Zhang X, Chai J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Aug;1870(6):159642

A Super-Enhancer-Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration-Resistant Prostate Cancer.

Jiang L, Wang J, Peng G, Zhang H, Fang J, Gao Y, Lou E, Liu Y, Ding W, Liu B, Mao Q, Jiang L, Liu A, Li X, Hu S, Ma Q, Zheng Y, Zhao Z, Shi X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e01284

THSR Mediated MiR374b Targeting C/EBP β/FOXO1 to Accelerate Thyroid Stimulating Hormone-Induced Hepatic Steatosis.

Li J, Ge Y, Chai Y, Kou C, Sun TT, Liu J, Zhang H
Hepatic medicine : evidence and research 2024;16:91-104

PKMYT1 knockdown inhibits cholesterol biosynthesis and promotes the drug sensitivity of triple-negative breast cancer cells to atorvastatin.

Gao W, Guo X, Sun L, Gai J, Cao Y, Zhang S
PeerJ 2024;12:e17749

Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response.

Xiao MY, Pei WJ, Li S, Li FF, Xie P, Luo HT, Hyun Yoo H, Piao XL
Bioorganic chemistry 2024 Sep;150:107539

Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.

Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y
Cell reports 2024 Sep 24;43(9):114691

Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice.

Itoh M, Watanabe K, Mizukami Y, Sugimoto H
Cell structure and function 2024 Oct 26;49(2):83-99

Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E-deficient mice.

Xu MY, Xu JJ, Kang LJ, Liu ZH, Su MM, Zhao WQ, Wang ZH, Sun L, Xiao JB, Evans PC, Tian XY, Wang L, Huang Y, Liang XM, Weng JP, Xu SW
Acta pharmacologica Sinica 2024 Nov;45(11):2277-2289

ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma.

Wu M, Zhou X, Zhou X, Wang G, Zeng Y, Li J, Prochownik EV, Wang F, Li Y
Cell reports 2024 Nov 26;43(11):114962

Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.

Zhu L, Shi Y, Feng Z, Yuan D, Guo S, Wang Y, Shen H, Li Y, Yan F, Wang Y
European journal of pharmacology 2024 May 15;971:176519

A gut-derived hormone regulates cholesterol metabolism.

Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y
Cell 2024 Mar 28;187(7):1685-1700.e18

Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis.

Shi Y, Wu D, Wang Y, Shao Y, Zeng F, Zhou D, Zhang H, Miao C
JCI insight 2024 Jun 18;9(14)

The lncRNA LINC01605 promotes the progression of pancreatic ductal adenocarcinoma by activating the mTOR signaling pathway.

Zhu YH, Jia QY, Yao HF, Duan ZH, Ma XS, Zheng JH, Yin YF, Liu W, Zhang JF, Hua R, Ma D, Sun YW, Yang JY, Liu DJ, Huo YM
Cancer cell international 2024 Jul 24;24(1):262

6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway.

Xia Q, Lu F, Chen Y, Li J, Huang Z, Fang K, Hu M, Guo Y, Dong H, Xu L, Gong J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116060

7-Dehydrocholesterol dictates ferroptosis sensitivity.

Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P
Nature 2024 Feb;626(7998):411-418

Dietary palm oil enhances Sterol regulatory element-binding protein 2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker (Larimichthys crocea).

Zhao Z, Li B, Chen Q, Xiang X, Xu X, Han S, Lai W, Li Y, Xu W, Mai K, Ai Q
The British journal of nutrition 2024 Feb 28;131(4):553-566

Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment.

Chen Y, Tao J, He Y, Hou X, Fang J, Huang J, Wang L, Shen J, Zhu B, Wang N, Cao A
Archives of pharmacal research 2024 Dec;47(12):924-939

Activated PARP1/FAK/COL5A1 signaling facilitates the tumorigenesis of cholesterol-resistant ovarian cancer cells through promoting EMT.

He Z, Gong S, Zhang X, Li J, Xue J, Zeng Q, Nie J, Zhang Z, Ding H, Pei H, Li B
Cellular signalling 2024 Dec;124:111419

miR-184, a downregulated ovary-elevated miRNA transcriptionally activated by SREBF2, exerts anti-apoptotic properties in ovarian granulosa cells through inducing SMAD3 expression.

Shan B, Huo Y, Guo Z, Li Q, Pan Z, Li Q, Du X
Cell death & disease 2024 Dec 18;15(12):892

Let-7f-5p Modulates Lipid Metabolism by Targeting Sterol Regulatory Element-Binding Protein 2 in Response to PRRSV Infection.

Jiang D, Yang L, Meng X, Xu Q, Zhou X, Liu B
Veterinary sciences 2024 Aug 26;11(9)

Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia.

Tan L, Kluivers ACM, Cruz-López EO, Broekhuizen M, Chen Z, Neuman RI, Schoenmakers S, Ruijgrok L, van de Velde D, de Winter BCM, van den Bogaerdt AJ, Lu X, Danser AHJ, Verdonk K
Hypertension (Dallas, Tex. : 1979) 2024 Apr;81(4):861-875

Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway.

Deng R, Zhu Y, Liu K, Zhang Q, Hu S, Wang M, Zhang Y
Bioorganic chemistry 2024 Apr;145:107212

Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1.

Xiao MY, Li FF, Xie P, Qi YS, Xie JB, Pei WJ, Luo HT, Guo M, Gu YL, Piao XL
Chemico-biological interactions 2023 Sep 25;383:110674

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.

Wang S, Zhou Y, Yu R, Ling J, Li B, Yang C, Cheng Z, Qian R, Lin Z, Yu C, Zheng J, Zheng X, Jia Q, Wu W, Wu Q, Chen M, Yuan S, Dong W, Shi Y, Jansen R, Yang C, Hao Y, Yao M, Qin W, Jin H
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843

Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.

Soares VC, Dias SSG, Santos JC, Azevedo-Quintanilha IG, Moreira IBG, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, da Silva MAN, Barreto-Vieira DF, Souza TM, Bozza PT
Life science alliance 2023 Nov;6(11)

B7H3 increases ferroptosis resistance by inhibiting cholesterol metabolism in colorectal cancer.

Jin H, Zhu M, Zhang D, Liu X, Guo Y, Xia L, Chen Y, Chen Y, Xu R, Liu C, Xi Q, Xia S, Shi T, Zhang G
Cancer science 2023 Nov;114(11):4225-4236

Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.

Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031

Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis.

Tang X, Qin Q, Xu W, Zhang X
Diabetes & metabolism journal 2023 Mar;47(2):267-286

The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB.

Fei X, Huang J, Li F, Wang Y, Shao Z, Dong L, Wu Y, Li B, Zhang X, Lv B, Zhao Y, Weng Q, Chen K, Zhang M, Yang S, Zhang C, Zhang M, Li W, Ying S, Sun Q, Chen Z, Shen H
Cell reports 2023 Jun 27;42(6):112586

Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.

Yang QC, Wang S, Liu YT, Song A, Wu ZZ, Wan SC, Li HM, Sun ZJ
iScience 2023 Jun 16;26(6):106916

Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.

Kong Y, Wu M, Wan X, Sun M, Zhang Y, Wu Z, Li C, Liang X, Gao L, Ma C, Yue X
Redox biology 2023 Jul;63:102732

LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition.

Zhang F, Gao J, Liu X, Sun Y, Liu L, Hu B, Wang Z, Shi J, Guo W, Zhang S
Molecular carcinogenesis 2023 Jul;62(7):963-974

Tilianin improves lipid profile and alleviates atherosclerosis in ApoE(-/-) mice through up-regulation of SREBP2-mediated LDLR expression.

Du Y, Xi M, Li Y, Zheng R, Ding X, Li X, Zhang X, Wang L, Xing J, Hong B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154577

Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.

Ge Y, Zhang L, Chen W, Sun M, Liu W, Li X
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.

Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638

Maternal high-calorie diet feeding programs hepatic cholesterol metabolism and Abca1 promoter methylation in the early life of offspring.

Zhang L, Zou W, Hu Y, Wu H, Gao Y, Zhang J, Zheng J
The Journal of nutritional biochemistry 2023 Dec;122:109449

Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.

La Y, Wong W, Peng K, Tian Z, Pan J, Sun R, Luan J, Yan K, Zhang Q, Zhang Z
Inflammation 2023 Aug;46(4):1575-1586

Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.

Hu Z, Yuan Y, Tong Z, Liao M, Yuan S, Wu W, Tang Y, Wang Y, Tang C, Liu W
International journal of molecular sciences 2023 Aug 16;24(16)

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis.

Zhou W, Liu H, Yuan Z, Zundell J, Towers M, Lin J, Lombardi S, Nie H, Murphy B, Yang T, Wang C, Liao L, Goldman AR, Kannan T, Kossenkov AV, Drapkin R, Montaner LJ, Claiborne DT, Zhang N, Wu S, Zhang R
Cancer cell 2023 Apr 10;41(4):740-756.e10

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

Zheng YK, Zhou ZS, Wang GZ, Tu JY, Cheng HB, Ma SZ, Ke C, Wang Y, Jian QP, Shu YH, Wu XW
Cell death & disease 2023 Apr 1;14(4):234

Osthole Increases the Sensitivity of Liver Cancer to Sorafenib by Inhibiting Cholesterol Metabolism.

Fan K, Huang H, Zhao Y, Xie T, Zhu ZY, Xie ML
Nutrition and cancer 2022;74(10):3640-3650

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.

Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867

The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes.

Luo HY, Li G, Liu YG, Wei YH, Chen JB, Gu XF, Tang JQ, Zhao Y, Su CH, Xiao LY, Xiong F, Zheng ZD, Wang SY, Zha LY
Current issues in molecular biology 2022 Oct 13;44(10):4822-4837

Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.

Hu S, Feng J, Wang M, Wufuer R, Liu K, Zhang Z, Zhang Y
Redox biology 2022 Nov;57:102470

AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.

Sheng N, Wang YQ, Wang CF, Jia MQ, Niu HM, Lu QQ, Wang YN, Feng D, Zheng XX, Yuan HQ
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916

Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.

Chen X, Jin X, Huang F, Wang J, Cao X, Wang PG, Feng Y, Jiang F, Yang G
European journal of medicinal chemistry 2022 Nov 5;241:114636

VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.

Temerozo JR, Sacramento CQ, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Dias SSG, Ferreira AC, Mattos M, Soares VC, Teixeira L, Azevedo-Quintanilha IG, Hottz ED, Kurtz P, Bozza FA, Bozza PT, Souza TML, Bou-Habib DC
Journal of leukocyte biology 2022 May;111(5):1107-1121

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.

Zeng H, Qin H, Liao M, Zheng E, Luo X, Xiao A, Li Y, Chen L, Wei L, Zhao L, Ruan XZ, Yang P, Chen Y
Molecular metabolism 2022 Mar;57:101428

Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish.

Cao X, Fang W, Li X, Wang X, Mai K, Ai Q
iScience 2022 Jul 15;25(7):104670

Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.

Lu Z, Huang L, Li Y, Xu Y, Zhang R, Zhou Q, Sun Q, Lu Y, Chen J, Shen Y, Li J, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(2):e2102669

Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer.

Hu X, Xiang J, Li Y, Xia Y, Xu S, Gao X, Qiao S
Biological & pharmaceutical bulletin 2022 Apr 1;45(4):438-445

The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.

Kong M, Zhu Y, Shao J, Fan Z, Xu Y
Frontiers in cell and developmental biology 2021;9:622866

SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.

Zhu T, Wang Z, Zou T, Xu L, Zhang S, Chen Y, Chen C, Zhang W, Wang S, Ding Q, Xu G
Frontiers in pharmacology 2021;12:769647

A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer.

Jin Y, Zhang Z, Zou S, Li F, Chen H, Peng C, Deng X, Wen C, Shen B, Zhan Q
Frontiers in oncology 2021;11:634881

Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.

Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280

LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.

Guo S, Zhang Y, Wang S, Yang T, Ma B, Li X, Zhang Y, Jiang X
Toxicology letters 2021 Sep 15;348:50-58

LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.

Tao M, Luo J, Gu T, Yu X, Song Z, Jun Y, Gu H, Han K, Huang X, Yu W, Sun S, Zhang Z, Liu L, Chen X, Zhang L, Luo C, Wang Q
Cell death & disease 2021 Sep 13;12(9):845

Xinnaokang improves cecal microbiota and lipid metabolism to target atherosclerosis.

Yang R, Yin D, Yang D, Liu X, Zhou Q, Pan Y, Li J, Li S
Letters in applied microbiology 2021 Dec;73(6):779-792

Fan Z, Kong M, Li M, Hong W, Fan X, Xu Y
Frontiers in cell and developmental biology 2020;8:259

Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology.

Chen K, Ma Z, Yan X, Liu J, Xu W, Li Y, Dai Y, Zhang Y, Xiao H
Frontiers in pharmacology 2020;11:528

The role of AMPKα2 in the HFD-induced nonalcoholic steatohepatitis.

Zhang X, Liu S, Zhang C, Zhang S, Yue Y, Zhang Y, Chen L, Yao Z, Niu W
Biochimica et biophysica acta. Molecular basis of disease 2020 Oct 1;1866(10):165854

Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.

Guo C, Xue H, Guo T, Zhang W, Xuan WQ, Ren YT, Wang D, Chen YH, Meng YH, Gao HL, Zhao P
Food & function 2020 Aug 1;11(8):7183-7196

Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.

He W, Xu Y, Ren X, Xiang D, Lei K, Zhang C, Liu D
Digestive diseases and sciences 2019 Nov;64(11):3182-3191

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