28212-1-AP

antibody from Proteintech Group

Targeting: SREBF2 bHLHd2, SREBP2

Provider product page for 28212-1-AP

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [47]
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Product number: 28212-1-AP - Provider product page
Provider: Proteintech Group
Product name: SREBF2 antibody
Antibody type: Polyclonal
Description: KD/KO validated SREBF2 antibody (Cat. #28212-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SREBF2 protein structure - 28212-1-AP shown in red.

Submitted references Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.

Zhu L, Shi Y, Feng Z, Yuan D, Guo S, Wang Y, Shen H, Li Y, Yan F, Wang Y
European journal of pharmacology 2024 May 15;971:176519

A gut-derived hormone regulates cholesterol metabolism.

Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y
Cell 2024 Mar 28;187(7):1685-1700.e18

6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway.

Xia Q, Lu F, Chen Y, Li J, Huang Z, Fang K, Hu M, Guo Y, Dong H, Xu L, Gong J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116060

7-Dehydrocholesterol dictates ferroptosis sensitivity.

Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P
Nature 2024 Feb;626(7998):411-418

Dietary palm oil enhances Sterol regulatory element-binding protein 2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker (Larimichthys crocea).

Zhao Z, Li B, Chen Q, Xiang X, Xu X, Han S, Lai W, Li Y, Xu W, Mai K, Ai Q
The British journal of nutrition 2024 Feb 28;131(4):553-566

Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia.

Tan L, Kluivers ACM, Cruz-López EO, Broekhuizen M, Chen Z, Neuman RI, Schoenmakers S, Ruijgrok L, van de Velde D, de Winter BCM, van den Bogaerdt AJ, Lu X, Danser AHJ, Verdonk K
Hypertension (Dallas, Tex. : 1979) 2024 Apr;81(4):861-875

Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway.

Deng R, Zhu Y, Liu K, Zhang Q, Hu S, Wang M, Zhang Y
Bioorganic chemistry 2024 Apr;145:107212

Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1.

Xiao MY, Li FF, Xie P, Qi YS, Xie JB, Pei WJ, Luo HT, Guo M, Gu YL, Piao XL
Chemico-biological interactions 2023 Sep 25;383:110674

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.

Wang S, Zhou Y, Yu R, Ling J, Li B, Yang C, Cheng Z, Qian R, Lin Z, Yu C, Zheng J, Zheng X, Jia Q, Wu W, Wu Q, Chen M, Yuan S, Dong W, Shi Y, Jansen R, Yang C, Hao Y, Yao M, Qin W, Jin H
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843

Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.

Soares VC, Dias SSG, Santos JC, Azevedo-Quintanilha IG, Moreira IBG, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, da Silva MAN, Barreto-Vieira DF, Souza TM, Bozza PT
Life science alliance 2023 Nov;6(11)

B7H3 increases ferroptosis resistance by inhibiting cholesterol metabolism in colorectal cancer.

Jin H, Zhu M, Zhang D, Liu X, Guo Y, Xia L, Chen Y, Chen Y, Xu R, Liu C, Xi Q, Xia S, Shi T, Zhang G
Cancer science 2023 Nov;114(11):4225-4236

Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.

Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031

Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis.

Tang X, Qin Q, Xu W, Zhang X
Diabetes & metabolism journal 2023 Mar;47(2):267-286

The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB.

Fei X, Huang J, Li F, Wang Y, Shao Z, Dong L, Wu Y, Li B, Zhang X, Lv B, Zhao Y, Weng Q, Chen K, Zhang M, Yang S, Zhang C, Zhang M, Li W, Ying S, Sun Q, Chen Z, Shen H
Cell reports 2023 Jun 27;42(6):112586

Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.

Yang QC, Wang S, Liu YT, Song A, Wu ZZ, Wan SC, Li HM, Sun ZJ
iScience 2023 Jun 16;26(6):106916

Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.

Kong Y, Wu M, Wan X, Sun M, Zhang Y, Wu Z, Li C, Liang X, Gao L, Ma C, Yue X
Redox biology 2023 Jul;63:102732

LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition.

Zhang F, Gao J, Liu X, Sun Y, Liu L, Hu B, Wang Z, Shi J, Guo W, Zhang S
Molecular carcinogenesis 2023 Jul;62(7):963-974

Tilianin improves lipid profile and alleviates atherosclerosis in ApoE(-/-) mice through up-regulation of SREBP2-mediated LDLR expression.

Du Y, Xi M, Li Y, Zheng R, Ding X, Li X, Zhang X, Wang L, Xing J, Hong B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154577

Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.

Ge Y, Zhang L, Chen W, Sun M, Liu W, Li X
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.

Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638

Maternal high-calorie diet feeding programs hepatic cholesterol metabolism and Abca1 promoter methylation in the early life of offspring.

Zhang L, Zou W, Hu Y, Wu H, Gao Y, Zhang J, Zheng J
The Journal of nutritional biochemistry 2023 Dec;122:109449

Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.

La Y, Wong W, Peng K, Tian Z, Pan J, Sun R, Luan J, Yan K, Zhang Q, Zhang Z
Inflammation 2023 Aug;46(4):1575-1586

Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.

Hu Z, Yuan Y, Tong Z, Liao M, Yuan S, Wu W, Tang Y, Wang Y, Tang C, Liu W
International journal of molecular sciences 2023 Aug 16;24(16)

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

Zheng YK, Zhou ZS, Wang GZ, Tu JY, Cheng HB, Ma SZ, Ke C, Wang Y, Jian QP, Shu YH, Wu XW
Cell death & disease 2023 Apr 1;14(4):234

Osthole Increases the Sensitivity of Liver Cancer to Sorafenib by Inhibiting Cholesterol Metabolism.

Fan K, Huang H, Zhao Y, Xie T, Zhu ZY, Xie ML
Nutrition and cancer 2022;74(10):3640-3650

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.

Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867

The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes.

Luo HY, Li G, Liu YG, Wei YH, Chen JB, Gu XF, Tang JQ, Zhao Y, Su CH, Xiao LY, Xiong F, Zheng ZD, Wang SY, Zha LY
Current issues in molecular biology 2022 Oct 13;44(10):4822-4837

Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.

Hu S, Feng J, Wang M, Wufuer R, Liu K, Zhang Z, Zhang Y
Redox biology 2022 Nov;57:102470

AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.

Sheng N, Wang YQ, Wang CF, Jia MQ, Niu HM, Lu QQ, Wang YN, Feng D, Zheng XX, Yuan HQ
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916

Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.

Chen X, Jin X, Huang F, Wang J, Cao X, Wang PG, Feng Y, Jiang F, Yang G
European journal of medicinal chemistry 2022 Nov 5;241:114636

VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.

Temerozo JR, Sacramento CQ, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Dias SSG, Ferreira AC, Mattos M, Soares VC, Teixeira L, Azevedo-Quintanilha IG, Hottz ED, Kurtz P, Bozza FA, Bozza PT, Souza TML, Bou-Habib DC
Journal of leukocyte biology 2022 May;111(5):1107-1121

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.

Zeng H, Qin H, Liao M, Zheng E, Luo X, Xiao A, Li Y, Chen L, Wei L, Zhao L, Ruan XZ, Yang P, Chen Y
Molecular metabolism 2022 Mar;57:101428

Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish.

Cao X, Fang W, Li X, Wang X, Mai K, Ai Q
iScience 2022 Jul 15;25(7):104670

Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.

Lu Z, Huang L, Li Y, Xu Y, Zhang R, Zhou Q, Sun Q, Lu Y, Chen J, Shen Y, Li J, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(2):e2102669

Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer.

Hu X, Xiang J, Li Y, Xia Y, Xu S, Gao X, Qiao S
Biological & pharmaceutical bulletin 2022 Apr 1;45(4):438-445

The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.

Kong M, Zhu Y, Shao J, Fan Z, Xu Y
Frontiers in cell and developmental biology 2021;9:622866

SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.

Zhu T, Wang Z, Zou T, Xu L, Zhang S, Chen Y, Chen C, Zhang W, Wang S, Ding Q, Xu G
Frontiers in pharmacology 2021;12:769647

A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer.

Jin Y, Zhang Z, Zou S, Li F, Chen H, Peng C, Deng X, Wen C, Shen B, Zhan Q
Frontiers in oncology 2021;11:634881

Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.

Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280

LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.

Guo S, Zhang Y, Wang S, Yang T, Ma B, Li X, Zhang Y, Jiang X
Toxicology letters 2021 Sep 15;348:50-58

LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.

Tao M, Luo J, Gu T, Yu X, Song Z, Jun Y, Gu H, Han K, Huang X, Yu W, Sun S, Zhang Z, Liu L, Chen X, Zhang L, Luo C, Wang Q
Cell death & disease 2021 Sep 13;12(9):845

Xinnaokang improves cecal microbiota and lipid metabolism to target atherosclerosis.

Yang R, Yin D, Yang D, Liu X, Zhou Q, Pan Y, Li J, Li S
Letters in applied microbiology 2021 Dec;73(6):779-792

Fan Z, Kong M, Li M, Hong W, Fan X, Xu Y
Frontiers in cell and developmental biology 2020;8:259

Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology.

Chen K, Ma Z, Yan X, Liu J, Xu W, Li Y, Dai Y, Zhang Y, Xiao H
Frontiers in pharmacology 2020;11:528

The role of AMPKα2 in the HFD-induced nonalcoholic steatohepatitis.

Zhang X, Liu S, Zhang C, Zhang S, Yue Y, Zhang Y, Chen L, Yao Z, Niu W
Biochimica et biophysica acta. Molecular basis of disease 2020 Oct 1;1866(10):165854

Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.

Guo C, Xue H, Guo T, Zhang W, Xuan WQ, Ren YT, Wang D, Chen YH, Meng YH, Gao HL, Zhao P
Food & function 2020 Aug 1;11(8):7183-7196

Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.

He W, Xu Y, Ren X, Xiang D, Lei K, Zhang C, Liu D
Digestive diseases and sciences 2019 Nov;64(11):3182-3191

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