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- Antibody Data
- Antigen structure
- References [8]
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- Product number
- ABIN374158 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Homolog (Drosophila) (NUMB) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide from C Terminus of the protein sequence according to NP_001005743. 1,001005744. 1, NP_003735, NP_001005745. 1. Genename: NUMBAA Sequence: C-PFSSDLQKTFEIEL
- Reactivity
- Human, Mouse, Bovine, Canine
- Host
- Goat
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/ml
- Storage
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing. Shelf life: one year from despatch.
Submitted references MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism.
NUMB does not impair growth and differentiation status of experimental gliomas.
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
Asymmetric localization of numb in the chick somite and the influence of myogenic signals.
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
Expression of the adaptor protein m-Numb in mouse male germ cells.
Sczaniecka M, Gladstone K, Pettersson S, McLaren L, Huart AS, Wallace M
The Journal of biological chemistry 2012 Apr 20;287(17):14052-68
The Journal of biological chemistry 2012 Apr 20;287(17):14052-68
NUMB does not impair growth and differentiation status of experimental gliomas.
Euskirchen P, Skaftnesmo KO, Huszthy PC, Brekkå N, Bjerkvig R, Jacobs AH, Miletic H
Experimental cell research 2011 Dec 10;317(20):2864-73
Experimental cell research 2011 Dec 10;317(20):2864-73
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley GQ
Nature medicine 2010 Aug;16(8):903-8
Nature medicine 2010 Aug;16(8):903-8
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T
Nature 2010 Aug 5;466(7307):765-8
Nature 2010 Aug 5;466(7307):765-8
NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
Ma Q, Zhou L, Shi H, Huo K
Cellular signalling 2008 Jun;20(6):1044-51
Cellular signalling 2008 Jun;20(6):1044-51
Asymmetric localization of numb in the chick somite and the influence of myogenic signals.
Holowacz T, Zeng L, Lassar AB
Developmental dynamics : an official publication of the American Association of Anatomists 2006 Mar;235(3):633-45
Developmental dynamics : an official publication of the American Association of Anatomists 2006 Mar;235(3):633-45
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M, Screpanti I, Gulino A
Nature cell biology 2006 Dec;8(12):1415-23
Nature cell biology 2006 Dec;8(12):1415-23
Expression of the adaptor protein m-Numb in mouse male germ cells.
Corallini S, Fera S, Grisanti L, Falciatori I, Muciaccia B, Stefanini M, Vicini E
Reproduction (Cambridge, England) 2006 Dec;132(6):887-97
Reproduction (Cambridge, England) 2006 Dec;132(6):887-97
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