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- Antigen structure
- References [258]
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- Western blot [1]
- Immunocytochemistry [2]
- Immunoprecipitation [1]
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- Product number
- 13057-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13057-2-AP, RRID:AB_2232034
- Product name
- G3BP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated G3BP1 antibody (Cat. #13057-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer.
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry.
Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules.
Hepatocyte TIA1 constrains metabolic steatohepatitis by translationally suppressing Srebf1 mRNA in stress granules.
Tannic acid inhibits viral replication by disrupting nucleocapsid condensation.
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Proteasome inhibition by VR23 enhances autophagic clearance of FUS(P525L)-mediated persistent stress granule in SH-SY5Y cells.
Talin-tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation.
Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1.
Huashi Baidu granules alleviates LPS-induced acute lung injury by targeting TACE-mediated inflammatory signaling and stress granules disassembly.
Proximity proteomics reveals OTUD6B regulation of stress granule dynamics through coalescence with VCP/p97.
Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants.
FUS protein nuclear loss in skin biopsy: A window into the pathology and diagnosis of fused in sarcoma-associated amyotrophic lateral sclerosis.
Astrocytic TIA1-Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model.
SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction.
Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression.
Advanced oxidation protein products exacerbate osteoarthritis progression by disrupting stress granules assembly via endoplasmic reticulum stress.
Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication.
Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4.
NSCLC cells sustain phase separation of cytoplasmic membrane-less organelles to protect themselves against cisplatin treatment.
DDX3X/MAVS alleviates doxorubicin‑induced cardiotoxicity by regulating stress granules.
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues.
ALKBH5-Mediated M(6)A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia-Reperfusion Injury.
Neurons and astrocytes have distinct organelle signatures and responses to stress.
Histone deacetylase 11 regulates stress granule formation to promote endothelial-to-mesenchymal transition in atherosclerosis.
Translation landscape of stress granules.
Proteotoxic stress response drives T cell exhaustion and immune evasion.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.
Metabolic traits shape responses to LSD1-directed therapy in glioblastoma tumor-initiating cells.
Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses.
The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response.
Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses.
PRAG1 Condensation Drives Cell Contraction Under Stress.
CircCBP Inhibits Influenza A Virus Replication by Interfering the vRNP Activity and Enhancing Antiviral Immune Response.
DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1.
G3BP1, a stress granule core protein, ameliorates metabolic dysfunction-associated fatty liver disease by attenuating hepatocyte lipid deposition.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1.
Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications.
Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS.
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis.
The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection.
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology.
Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice.
Induction of translation-suppressive G3BP1(+) stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA.
Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations.
Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity.
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells.
HP-Bodies - Ancestral Condensates that Regulate RNA Turnover and Protein Translation in Bacteria.
RACK1 MARylation regulates translation and stress granules in ovarian cancer cells.
TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction.
ZBP1 orchestrates dynamic transitions between cell death pathways in response to arsenic and hyperosmotic stress.
Senecavirus a can replicate in apical-out porcine intestinal organoids and induce stress granules and innate immune response.
TIA1-mediated stress granules promote neurodegeneration by sequestering HSP70 mRNA in C9orf72 mice.
Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma.
[Indole-3-acetic acid alleviates Cryptococcus neoformans-induced pyroptosis in cerebral microvascular endothelial cells by regulating stress granule-mediated NLRP3 inflammasome activation].
G3BP1 maintains endothelial barrier integrity through dual mechanisms: direct stabilization of junction protein mRNAs and suppression of the inflammatory MYD88-ARNO-ARF6 pathway.
Stress granule-mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging.
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.
The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model.
Perillaldehyde Improves Parkinson-Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models.
TIA1-Mediated Stress Granules Promote the Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis through Upregulating IL-31RA Signaling.
Localizatome: a database for stress-dependent subcellular localization changes in proteins.
Stress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure.
Neuroprotective effects of ellorarxine in neuronal models of degeneration.
African swine fever virus RNA polymerase subunits C315R and H359L inhibition host translation by activating the PKR-eIF2a pathway and suppression inflammatory responses.
Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms.
A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells.
Downregulation of Lnc-ABCA12-3 modulates UBQLN1 expression and protein homeostasis pathways in amyotrophic lateral sclerosis.
Stress Granule Assembly in Pulmonary Arterial Hypertension.
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties.
C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology.
Stress granules are not present in Kras mutant cancers and do not control tumor growth.
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.
Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.
Infection with novel duck reovirus induces stress granule and methylation-mediated host translational shutoff in Muscovy ducklings.
G3BP isoforms differentially affect stress granule assembly and gene expression during cellular stress.
High-throughput tagging of endogenous loci for rapid characterization of protein function.
Overexpression of RBM15 modulated the effect of trophoblast cells by promoting the binding ability between YTHDF2 and the CD82 3'UTR to decrease the expression of CD82.
ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models.
Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer.
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study.
Mammalian IRE1α dynamically and functionally coalesces with stress granules.
LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.
Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X.
Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies.
The mRNA-capping enzyme localizes to stress granules in the cytoplasm and maintains cap homeostasis of target mRNAs.
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress.
A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation.
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Dynamic proximity interaction profiling suggests that YPEL2 is involved in cellular stress surveillance.
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress.
Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex.
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination.
Stress granules play a critical role in hexavalent chromium-induced malignancy in a G3BP1 dependent manner.
Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome.
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network.
The Raf kinase inhibitors Dabrafenib and Regorafenib impair Zika virus replication via distinct mechanisms.
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.
Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis.
Identification and validation of a novel stress granules-related prognostic model in colorectal cancer.
TRIM25-mediated ubiquitination of G3BP1 regulates the proliferation and migration of human neuroblastoma cells.
Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation.
Rosmarinic acid ameliorates autoimmune responses through suppression of intracellular nucleic acid-mediated type I interferon expression.
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis.
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Stress granules plug and stabilize damaged endolysosomal membranes.
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer.
Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis.
Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.
Molecular Graph-Based Deep Learning Algorithm Facilitates an Imaging-Based Strategy for Rapid Discovery of Small Molecules Modulating Biomolecular Condensates.
Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases.
In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.
circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR.
ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation.
The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.
Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules.
The ZSWIM8 ubiquitin ligase regulates neurodevelopment by guarding the protein quality of intrinsically disordered Dab1.
Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43.
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.
Stress granules affect the sensitivity of renal cancer cells to sorafenib by sequestering and stabilizing COX‑2 mRNA.
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges.
African swine fever virus pS273R antagonizes stress granule formation by cleaving the nucleating protein G3BP1 to facilitate viral replication.
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.
Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia.
TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Integrative genetic analysis illuminates ALS heritability and identifies risk genes.
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.
Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis.
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.
LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure.
Screening Linear and Circular RNA Transcripts from Stress Granules.
Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor-associated macrophages.
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.
Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.
Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome.
C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
RNA supply drives physiological granule assembly in neurons.
Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS.
CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy.
The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm.
Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells.
cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium.
Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation.
Viral evasion of PKR restriction by reprogramming cellular stress granules.
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules.
MxB inhibits long interspersed element type 1 retrotransposition.
Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1.
c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation.
Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.
Upregulated LINC01088 facilitates malignant phenotypes and immune escape of colorectal cancer by regulating microRNAs/G3BP1/PD-L1 axis.
ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain-of-function.
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner.
Orf Virus ORF120 Protein Positively Regulates the NF-κB Pathway by Interacting with G3BP1.
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA.
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells.
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection.
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production.
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly.
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins.
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Rapid prediction of drug inhibition under heat stress: single-photon imaging combined with a convolutional neural network.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Capturing RNA-protein interaction via CRUIS.
Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases?
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells.
Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis.
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics.
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptidesin Semi-permeabilized Human Cells.
G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer.
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
m(6)A enhances the phase separation potential of mRNA.
Lysine/RNA-interactions drive and regulate biomolecular condensation.
Stress granules are formed in renal proximal tubular cells during metabolic stress and ischemic injury for cell survival.
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.
G3BP1 promotes DNA binding and activation of cGAS.
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression.
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology.
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.
A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.
TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations.
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1.
De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies.
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis.
G3BP1 contributes to tumor metastasis via upregulation of Slug expression in hepatocellular carcinoma.
Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.
ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.
Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function.
The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.
Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer.
Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS).
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
Lin Z, Gao Y, Zhang Q, Yang S, Chen Y, Ding H, Peng W, Zhang X, Nurzat Y, Hu J, Liao W, Xiong B, Xiao M, Zhang X
Cancer letters 2026 May 1;645:218392
Cancer letters 2026 May 1;645:218392
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry.
Annunziato S, Quan C, Donckele EJ, Lamberto I, Bunker RD, Zlotosch M, Schwander L, Murthy A, Wiedmer L, Staehly C, Matysik M, Gilberto S, Kapsitidou D, Wible D, De Donatis GM, Trenh P, SriRamaratnam R, Strande V, Lieberherr R, Lyon D, Steiner D, Silva J, Almeida R, Dolgikh E, DeMarco B, Tsai J, Sadok A, Zarayskiy V, Walter M, Tiedt R, Lumb KJ, Bonenfant D, Fasching B, Castle JC, Townson SA, Gainza P, Petzold G
Nature structural & molecular biology 2026 Mar;33(3):479-487
Nature structural & molecular biology 2026 Mar;33(3):479-487
Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules.
Kim SS, Ham S, Boo SH, Lee D, Min H, Kang E, Haque R, Lee H, Jung Y, Kwon S, Park S, Park HH, Kim EJE, Hwang W, Kim E, Lee GY, Park KY, Suh JM, Lee G, Kim YK, Lee SV
Molecular cell 2026 Mar 5;86(5):885-900.e14
Molecular cell 2026 Mar 5;86(5):885-900.e14
Hepatocyte TIA1 constrains metabolic steatohepatitis by translationally suppressing Srebf1 mRNA in stress granules.
Liu R, Chen J, Wang J, Zhang T, Xia Y, Feng J, Guo C, Xue L, Zhou Y
Cell death & disease 2026 Mar 24;17(1)
Cell death & disease 2026 Mar 24;17(1)
Tannic acid inhibits viral replication by disrupting nucleocapsid condensation.
Pan J, Jiang SZ, Zhu Y, Li XW, Yu LB, Wang Z, Shen BL, Luo RB, Fan LJ, Yu Y, Qian BS, Wang ZJ, Liu Y, Cai H, Xue W, Xia T, Han QY, Wang K, Xu X, He XH, Chen Y, Gao Y, Li AL, Li T, Zhang R, Zhao M, Zhou T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158151
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158151
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Guo L, Mann JR, Mauna JC, Copley KE, Wang H, Rubien JD, Bergmann CA, Carey JL, Merjane J, Ngo M, Xu J, Odeh HM, Lin J, Lee BL, Ganser L, Robinson E, Kim KM, Murthy AC, Paul T, Portz B, Gleixner AM, Diaz Z, Smirnov A, Padilla G, Lavorando E, Espy C, Shang Y, Huang EJ, Chesi A, Fawzi NL, Myong S, Donnelly CJ, Shorter J
Molecular cell 2026 Jan 8;86(1):114-134.e10
Molecular cell 2026 Jan 8;86(1):114-134.e10
Proteasome inhibition by VR23 enhances autophagic clearance of FUS(P525L)-mediated persistent stress granule in SH-SY5Y cells.
Kim SH, So JH, Kim YH, Kim HS, Park NY, Kim JB, Jo DS, Yeom E, Lee JA, Bae JE, Cho DH
Molecular brain 2026 Jan 8;19(1):10
Molecular brain 2026 Jan 8;19(1):10
Talin-tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation.
Li X, Konstantinou R, Meena VK, Notash S, Khalil K, Whalley T, Atherton P, Barsukov I, Zacharchenko T, Ballestrem C
The Journal of cell biology 2026 Jan 5;225(1)
The Journal of cell biology 2026 Jan 5;225(1)
Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1.
Chen S, Yu P, Sun Y, Yan Y, Zhang B, Li G
Journal of translational medicine 2026 Jan 2;24(1):226
Journal of translational medicine 2026 Jan 2;24(1):226
Huashi Baidu granules alleviates LPS-induced acute lung injury by targeting TACE-mediated inflammatory signaling and stress granules disassembly.
Ma Y, Zhang J, Gong J, Yang W, Huang J, Sun Y
Journal of ethnopharmacology 2026 Jan 10;354:120580
Journal of ethnopharmacology 2026 Jan 10;354:120580
Proximity proteomics reveals OTUD6B regulation of stress granule dynamics through coalescence with VCP/p97.
Yang D, Liu Y, Hong Y, Miao E, Wang P, Sun Y, Zhou L, Liu S, Zhang Y, Qin H, Ye M, Liu H
Cell death & disease 2026 Feb 6;17(1):206
Cell death & disease 2026 Feb 6;17(1):206
Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants.
Steinbock RT, Scudero OB, Dybas JM, Abbott ARN, Kulej K, Lauman R, Chan H, Agostino EL, Kumar N, Briggs S, Parenti NA, Li Y, Burke JM, Weiss SR, Price AM, Weitzman MD
bioRxiv : the preprint server for biology 2026 Feb 18;
bioRxiv : the preprint server for biology 2026 Feb 18;
FUS protein nuclear loss in skin biopsy: A window into the pathology and diagnosis of fused in sarcoma-associated amyotrophic lateral sclerosis.
Shan D, Sun X, Tang Y, Zhao Y, Yan C, Liu F
Journal of neuropathology and experimental neurology 2026 Feb 1;85(2):203-205
Journal of neuropathology and experimental neurology 2026 Feb 1;85(2):203-205
Astrocytic TIA1-Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model.
Fang Z, Hua X, Fan Z, Zhao J, Zhang Y, Zhang Q, Qu X, Pan S, Wan B, Yang S, Li J, Zhang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e20299
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e20299
SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction.
Liu X, Zong Y, Liu K, Shi X, Zhao Z, Shan C, Sun Y
Cell reports 2026 Apr 4;45(4):117251
Cell reports 2026 Apr 4;45(4):117251
Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression.
Yue T, Yin H, Yuan L, Xie X, Xie H, Gong M, Xu X, Sun C, Zhang K, Liu J
Oncogene 2026 Apr 24;
Oncogene 2026 Apr 24;
Advanced oxidation protein products exacerbate osteoarthritis progression by disrupting stress granules assembly via endoplasmic reticulum stress.
Jiang W, Wang Q, Zhang X, Qi B, Liang Y, Li D, Yi C
Free radical biology & medicine 2026 Apr 18;251:440-453
Free radical biology & medicine 2026 Apr 18;251:440-453
Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication.
Aromokeye R, Kuang L, Ackerman-Berrier M, Cardoza S, Holberg C, Carver M, Ma C, Tharappel AM, Li H, Wang L, Thatcher GRJ, Zhu H
ACS infectious diseases 2026 Apr 10;
ACS infectious diseases 2026 Apr 10;
Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4.
Chen L, Gao Y, Hao X, Yang X, Lindström M, Jiang S, Cao X, Liu H, Nyström T, Sunnerhagen P, Liu B
Theranostics 2025;15(5):1987-2005
Theranostics 2025;15(5):1987-2005
NSCLC cells sustain phase separation of cytoplasmic membrane-less organelles to protect themselves against cisplatin treatment.
Li NN, Rao LL, Su D, Liu BH, Ma GQ, Wang HF, Zhang ZL, Ying Z
Acta pharmacologica Sinica 2025 Sep;46(9):2522-2533
Acta pharmacologica Sinica 2025 Sep;46(9):2522-2533
DDX3X/MAVS alleviates doxorubicin‑induced cardiotoxicity by regulating stress granules.
Zhao K, Wang S, Feng D, Wang D, Yang G, Lang F
Molecular medicine reports 2025 Sep;32(3)
Molecular medicine reports 2025 Sep;32(3)
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues.
Cheng QX, Xie G, Zhang X, Wang J, Ding S, Wu YX, Shi M, Duan FF, Wan ZL, Wei JJ, Xiao J, Wang Y
Nature methods 2025 Sep;22(9):1824-1835
Nature methods 2025 Sep;22(9):1824-1835
ALKBH5-Mediated M(6)A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia-Reperfusion Injury.
Li W, Li W, Leng Y, Xu H, Xia Z, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e07254
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e07254
Neurons and astrocytes have distinct organelle signatures and responses to stress.
Rhoads SN, Dong W, Hsu CH, Mfulama NR, Yarlagadda R, Ragusa JV, Ye M, Henrie A, Zanellati MC, Diering GH, Cohen TJ, Cohen S
Cell reports 2025 Sep 23;44(9):116280
Cell reports 2025 Sep 23;44(9):116280
Histone deacetylase 11 regulates stress granule formation to promote endothelial-to-mesenchymal transition in atherosclerosis.
Ren L, Liu Y, Chen D, Rong X, Wen J, Zheng Z, Chen L, He J, Wang W, Lin R
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120026
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120026
Translation landscape of stress granules.
Wu Y, Wang X, Meng L, Liao Z, Ji W, Zhang P, Lin J, Guo Q
Science advances 2025 Oct 3;11(40):eady6859
Science advances 2025 Oct 3;11(40):eady6859
Proteotoxic stress response drives T cell exhaustion and immune evasion.
Wang Y, Ma A, Song NJ, Shannon AE, Amankwah YS, Chen X, Wu W, Wang Z, Saadey AA, Yousif A, Ghosh G, Mandula JK, Velegraki M, Xiao T, Wen H, Huang SC, Wang R, Beusch CM, Dawood AS, Gordon DE, Abdel-Hakeem MS, Ghoneim HE, Xin G, Searle BC, Li Z
Nature 2025 Nov;647(8091):1025-1035
Nature 2025 Nov;647(8091):1025-1035
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.
Xiong X, Wang X, Wang Z, Chen F, Shi Y, Chen X, Gong W, Jia X, Xu J
Cell reports 2025 Nov 25;44(11):116511
Cell reports 2025 Nov 25;44(11):116511
Metabolic traits shape responses to LSD1-directed therapy in glioblastoma tumor-initiating cells.
Marotta G, Osti D, Zaccheroni E, Costanza B, Faletti S, Marinaro A, Richichi C, Mesa D, Rodighiero S, Soriani C, Migliaccio E, Ruscitto F, Priami C, Sigismund S, Manetti F, Polli D, Beznusenko GV, Rusu MC, Favero F, Corà D, Silvestris DA, Gallo A, Gambino V, Alfieri F, Gandini S, Schmitt MJ, Gargiulo G, Noberini R, Bonaldi T, Pelicci G
Science advances 2025 May 23;11(21):eadt2724
Science advances 2025 May 23;11(21):eadt2724
Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses.
Travers J, Huang E, McMullen MR, Wu J, Cajigas-Du Ross CK, Paouri E, Davalos D, Pathak V, Rotroff DM, Nagy LE
bioRxiv : the preprint server for biology 2025 May 15;
bioRxiv : the preprint server for biology 2025 May 15;
The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response.
Deshaies JE, Triassi V, Lacombe A, Gagné M, Ling K, Ghosh A, Labrecque M, Rigo F, Jafar-Nejad P, Tétreault M, Vande Velde C
Scientific reports 2025 May 1;15(1):15306
Scientific reports 2025 May 1;15(1):15306
Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses.
Shi M, Jiang T, Zhang M, Li Q, Liu K, Lin N, Wang X, Jiang A, Gao Y, Wang Y, Liu S, Zhang L, Li D, Gao P
Molecular cell 2025 Mar 6;85(5):962-975.e7
Molecular cell 2025 Mar 6;85(5):962-975.e7
PRAG1 Condensation Drives Cell Contraction Under Stress.
Ye P, Jiang P, Ye L, Liu M, Fang Q, Yu P, Luo J, Su H, Yang W
Biomolecules 2025 Mar 5;15(3)
Biomolecules 2025 Mar 5;15(3)
CircCBP Inhibits Influenza A Virus Replication by Interfering the vRNP Activity and Enhancing Antiviral Immune Response.
Yao X, Wang M, Tong X, Qi D, Ye X
Journal of medical virology 2025 Jun;97(6):e70442
Journal of medical virology 2025 Jun;97(6):e70442
DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1.
Han P, Ye W, Ma H, Dong Y, Lv X, Liu H, Cheng L, Zhang L, Li S, Lei Y, Zhang F
International journal of medical microbiology : IJMM 2025 Jun;319:151654
International journal of medical microbiology : IJMM 2025 Jun;319:151654
G3BP1, a stress granule core protein, ameliorates metabolic dysfunction-associated fatty liver disease by attenuating hepatocyte lipid deposition.
Liu X, Yu H, Hu T, He Y, Li Y, Yuan Q, Dong M, Liu D, Xu Y, Mao L
Diabetes, obesity & metabolism 2025 Jun;27(6):2985-2995
Diabetes, obesity & metabolism 2025 Jun;27(6):2985-2995
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1.
Li Y, Fang J, Ding Y, Zhang X, Liu Y, Qiu W, Xu H, Kang Y, Chen J, Gao Y, Zhao YG, Yang P, Wang B, Tian W, Chen Y, Bi W, Zhang P
Nature communications 2025 Jun 5;16(1):5227
Nature communications 2025 Jun 5;16(1):5227
Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications.
Fabbrizio P, Baindoor S, Margotta C, Su J, Morrissey EP, Woods I, Hogg MC, Vianello S, Venø MT, Kjems J, Sorarù G, Bendotti C, Prehn JHM, Nardo G
Brain pathology (Zurich, Switzerland) 2025 Jul;35(4):e13328
Brain pathology (Zurich, Switzerland) 2025 Jul;35(4):e13328
Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS.
Ma G, Ruan X, Yang B, Li N, Su D, Sun S, Chen S, Xu K, Ying Z, Wang H
The Journal of biological chemistry 2025 Jul;301(7):110259
The Journal of biological chemistry 2025 Jul;301(7):110259
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis.
Ganssauge J, Hawkins S, Namboori SC, Leung SK, Mill J, Bhinge A
eLife 2025 Jul 24;13
eLife 2025 Jul 24;13
The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection.
Lavender AA, Solanke O, Tang H-Y, Peck HE, Vanover D, Santangelo PJ, Brinton MA
Journal of virology 2025 Jul 22;99(7):e0079425
Journal of virology 2025 Jul 22;99(7):e0079425
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology.
Mohan HM, Fernandez MG, Huang C, Lin R, Ryou JH, Seyfried D, Grotewold N, Barget AJ, Whiteley AM, Basrur V, Mosalaganti S, Paulson HL, Sharkey LM
Science advances 2025 Jul 18;11(29):eadu6354
Science advances 2025 Jul 18;11(29):eadu6354
Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice.
Zhou Y, Yang Z, Wang Y, Dong Y, Wang T, Li Y, Liang C, Liu Y, Li Z, Liu S, Gui L, Fan Y, Lei T, Jia K, Zhang L, Wang M, Nie W, Chen L, Ma M, Wu Y, Zhong C, Liu H, Hou J
Nature communications 2025 Jul 1;16(1):5610
Nature communications 2025 Jul 1;16(1):5610
Induction of translation-suppressive G3BP1(+) stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA.
Majerciak V, Zheng ZM
hLife 2025 Jan;3(1):21-37
hLife 2025 Jan;3(1):21-37
Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations.
Mosti F, Hoye ML, Escobar-Tomlienovich CF, Silver DL
PLoS genetics 2025 Jan;21(1):e1011555
PLoS genetics 2025 Jan;21(1):e1011555
Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity.
Ru S, Tang S, Xu H, Yin J, Guo Y, Song L, Jin Z, Lee D, Chan YH, Chen X, Buerer L, Fairbrother W, Jia W, Casanova JL, Zhang SY, Gao D
The Journal of experimental medicine 2025 Jan 6;222(1)
The Journal of experimental medicine 2025 Jan 6;222(1)
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells.
Lin CR, Hayek H, Simborio H, Karim L, Bahmed K, Bolla S, Marchetti N, Criner GJ, Tian Y, Kosmider B
Aging and disease 2025 Jan 14;17(1):367-382
Aging and disease 2025 Jan 14;17(1):367-382
HP-Bodies - Ancestral Condensates that Regulate RNA Turnover and Protein Translation in Bacteria.
Guan J, Hurto RL, Rai A, Azaldegui CA, Ortiz-Rodríguez LA, Biteen JS, Freddolino L, Jakob U
bioRxiv : the preprint server for biology 2025 Feb 6;
bioRxiv : the preprint server for biology 2025 Feb 6;
RACK1 MARylation regulates translation and stress granules in ovarian cancer cells.
Challa S, Nandu T, Kim HB, Gong X, Renshaw CW, Li WC, Tan X, Aljardali MW, Camacho CV, Chen J, Kraus WL
The Journal of cell biology 2025 Feb 3;224(2)
The Journal of cell biology 2025 Feb 3;224(2)
TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction.
Mamede LD, Hu M, Titus AR, Vaquer-Alicea J, French RL, Diamond MI, Miller TM, Ayala YM
bioRxiv : the preprint server for biology 2025 Feb 12;
bioRxiv : the preprint server for biology 2025 Feb 12;
ZBP1 orchestrates dynamic transitions between cell death pathways in response to arsenic and hyperosmotic stress.
Fu Y, Yang Y, Li Q, Xia X, Peng M, Meng S, Shen R, Zhu Y, Jiao H, Kim C, Lin J
The Journal of biological chemistry 2025 Dec;301(12):110856
The Journal of biological chemistry 2025 Dec;301(12):110856
Senecavirus a can replicate in apical-out porcine intestinal organoids and induce stress granules and innate immune response.
Wang Y, Wei Z, Li J, Wang X, Jiang Y, Cui W, Shan Z, Tang L
Virulence 2025 Dec;16(1):2548623
Virulence 2025 Dec;16(1):2548623
TIA1-mediated stress granules promote neurodegeneration by sequestering HSP70 mRNA in C9orf72 mice.
Wei Y, Li D, Yang R, Liu Y, Luo X, Zhao W, Yang H, Chen Z, Shen C, Wang Y, Huang Z
Brain : a journal of neurology 2025 Dec 4;148(12):4482-4494
Brain : a journal of neurology 2025 Dec 4;148(12):4482-4494
Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma.
Wang S, Guo P, Ma W, Huang H, Zhang Q, Wolczynski S, Rahman N, Liu J, Tsang SY, Du X, Wang F, Gao J, Li X
Cell reports 2025 Dec 23;44(12):116588
Cell reports 2025 Dec 23;44(12):116588
[Indole-3-acetic acid alleviates Cryptococcus neoformans-induced pyroptosis in cerebral microvascular endothelial cells by regulating stress granule-mediated NLRP3 inflammasome activation].
Chen J, Zou J, Zhou B, Gao X, Huang P, Cao H
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2679-2689
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2679-2689
G3BP1 maintains endothelial barrier integrity through dual mechanisms: direct stabilization of junction protein mRNAs and suppression of the inflammatory MYD88-ARNO-ARF6 pathway.
Sun W, Wu H, He Y, Chen H, Meng Y, Tang G, Zhu J, Wen Z, Zhang H, Wu R, Wu G, Zhang C, Chu M, Wen B
Angiogenesis 2025 Aug 25;28(4):46
Angiogenesis 2025 Aug 25;28(4):46
Stress granule-mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging.
Lei H, Li D, Chen J, Du B, Jiang K, Xu T, Han H, Fan W, Tian L, Wang X
Proceedings of the National Academy of Sciences of the United States of America 2025 Aug 19;122(33):e2514837122
Proceedings of the National Academy of Sciences of the United States of America 2025 Aug 19;122(33):e2514837122
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.
Ouyang Q, Su J, Li Y, Liao H, Guo H, Sun Y, Wang X, Chen J, Thinwa J, Ding WX, Tilg H, Ren F, Zhang H, Liu R
Nature communications 2025 Aug 14;16(1):7570
Nature communications 2025 Aug 14;16(1):7570
The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model.
Bian Y, Fukui Y, Ota-Elliott RS, Hu X, Sun H, Bian Z, Zhai Y, Yu H, Hu X, An H, Liu H, Morihara R, Ishiura H, Yamashita T
Neuroscience research 2025 Apr;213:128-137
Neuroscience research 2025 Apr;213:128-137
Perillaldehyde Improves Parkinson-Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models.
Fang M, Luo L, Chen Y, Liu Y, Yan Y, Wang F, Zou Y, Zhu H, Wu X, Jin Z, Huang C, Zhang Y, Fan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2412152
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2412152
TIA1-Mediated Stress Granules Promote the Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis through Upregulating IL-31RA Signaling.
Hua X, Jin L, Fang Z, Weng Y, Zhang Y, Zhang J, Xie D, Tang Y, Guo S, Huang Y, Dai Y, Li J, Huang Z, Zhang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409086
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409086
Localizatome: a database for stress-dependent subcellular localization changes in proteins.
Matsushima T, Naito Y, Chiba T, Kurimoto R, Itano K, Ochiai K, Takahashi K, Goshima N, Asahara H
Database : the journal of biological databases and curation 2025 Apr 21;2025
Database : the journal of biological databases and curation 2025 Apr 21;2025
Stress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure.
Abdelrasol H, Chopra A, Shvachiy L, Beutner D, Outeiro TF, Setz C
Cell stress 2024;8:83-98
Cell stress 2024;8:83-98
Neuroprotective effects of ellorarxine in neuronal models of degeneration.
Kouchmeshky A, Whiting A, McCaffery P
Frontiers in neuroscience 2024;18:1422294
Frontiers in neuroscience 2024;18:1422294
African swine fever virus RNA polymerase subunits C315R and H359L inhibition host translation by activating the PKR-eIF2a pathway and suppression inflammatory responses.
Yang S, Wang Y, Yang J, Tian Z, Wu M, Sun H, Zhang X, Zhao Y, Luo J, Guan G, Yin H, Hao R, Niu Q
Frontiers in microbiology 2024;15:1469166
Frontiers in microbiology 2024;15:1469166
Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms.
Sun H, Yang B, Li Q, Zhu X, Song E, Liu C, Song Y, Jiang G
Nature nanotechnology 2024 Sep;19(9):1354-1365
Nature nanotechnology 2024 Sep;19(9):1354-1365
A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells.
Challa S, Nandu T, Kim HB, Gong X, Renshaw CW, Li WC, Tan X, Aljardali MW, Camacho CV, Chen J, Kraus WL
bioRxiv : the preprint server for biology 2024 Sep 4;
bioRxiv : the preprint server for biology 2024 Sep 4;
Downregulation of Lnc-ABCA12-3 modulates UBQLN1 expression and protein homeostasis pathways in amyotrophic lateral sclerosis.
Yu Y, Pang D, Huang J, Li C, Cui Y, Shang H
Scientific reports 2024 Sep 13;14(1):21383
Scientific reports 2024 Sep 13;14(1):21383
Stress Granule Assembly in Pulmonary Arterial Hypertension.
Kosmas K, Papathanasiou AE, Spyropoulos F, Rehman R, Cunha AA, Fredenburgh LE, Perrella MA, Christou H
Cells 2024 Oct 30;13(21)
Cells 2024 Oct 30;13(21)
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties.
Mohan HM, Fernandez MG, Huang C, Lin R, Ryou JH, Seyfried D, Grotewold N, Whiteley AM, Barmada SJ, Basrur V, Mosalaganti S, Paulson HL, Sharkey LM
bioRxiv : the preprint server for biology 2024 Oct 25;
bioRxiv : the preprint server for biology 2024 Oct 25;
C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology.
Hodgson RE, Rayment JA, Huang WP, Sanchez Avila A, Ellis BCS, Lin YH, Soni N, Hautbergue GM, Shelkovnikova TA
iScience 2024 Oct 18;27(10):110937
iScience 2024 Oct 18;27(10):110937
Stress granules are not present in Kras mutant cancers and do not control tumor growth.
Libert M, Quiquempoix S, Fain JS, Pyr Dit Ruys S, Haidar M, Wulleman M, Herinckx G, Vertommen D, Bouchart C, Arsenijevic T, Van Laethem JL, Jacquemin P
EMBO reports 2024 Nov;25(11):4693-4707
EMBO reports 2024 Nov;25(11):4693-4707
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.
Okada K, Ito D, Morimoto S, Kato C, Oguma Y, Warita H, Suzuki N, Aoki M, Kuramoto J, Kobayashi R, Shinozaki M, Ikawa M, Nakahara J, Takahashi S, Nishimoto Y, Shibata S, Okano H
Brain : a journal of neurology 2024 Nov 4;147(11):3933-3948
Brain : a journal of neurology 2024 Nov 4;147(11):3933-3948
Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.
Fan B, Li Y, Wang Y, Yang S, Peng Q, Qian J, Wang C, Zhang X, Xu H, Liu S, He W, Zhang G, Zhu X, Li Y, Zhao Y, Hu M, Wang W, Zhou J, Guo R, He K, Li B
Nucleic acids research 2024 Nov 27;52(21):13174-13191
Nucleic acids research 2024 Nov 27;52(21):13174-13191
Infection with novel duck reovirus induces stress granule and methylation-mediated host translational shutoff in Muscovy ducklings.
Yun T, Hua J, Chen L, Ye W, Ni Z, Zhu Y, Zhang C
Communications biology 2024 Nov 21;7(1):1549
Communications biology 2024 Nov 21;7(1):1549
G3BP isoforms differentially affect stress granule assembly and gene expression during cellular stress.
Liboy-Lugo JM, Espinoza CA, Sheu-Gruttadauria J, Park JE, Xu A, Jowhar Z, Gao AL, Carmona-Negrón JA, Wittmann T, Jura N, Floor SN
Molecular biology of the cell 2024 Nov 1;35(11):ar140
Molecular biology of the cell 2024 Nov 1;35(11):ar140
High-throughput tagging of endogenous loci for rapid characterization of protein function.
Kim J, Kratz AF, Chen S, Sheng J, Kim HK, Zhang L, Singh BK, Chavez A
Science advances 2024 May 3;10(18):eadg8771
Science advances 2024 May 3;10(18):eadg8771
Overexpression of RBM15 modulated the effect of trophoblast cells by promoting the binding ability between YTHDF2 and the CD82 3'UTR to decrease the expression of CD82.
You G, Li Z, Li L, Xu C
Heliyon 2024 May 15;10(9):e30702
Heliyon 2024 May 15;10(9):e30702
ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models.
Hu R, Chen X, Su Q, Wang Z, Wang X, Gong M, Xu M, Le R, Gao Y, Dai P, Zhang ZN, Shao L, Li W
Cell death and differentiation 2024 Mar;31(3):322-334
Cell death and differentiation 2024 Mar;31(3):322-334
Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer.
Mao S, Xie C, Liu Y, Zhao Y, Li M, Gao H, Xiao Y, Zou Y, Zheng Z, Gao Y, Xie J, Tian B, Wang L, Hua Y, Xu H
Cellular and molecular life sciences : CMLS 2024 Mar 4;81(1):113
Cellular and molecular life sciences : CMLS 2024 Mar 4;81(1):113
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Clary JE, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvarado RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP
Cell reports 2024 Mar 26;43(3):113965
Cell reports 2024 Mar 26;43(3):113965
Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study.
Bidot S, Yin J, Zhou P, Zhang L, Deeb KK, Smith G, Hill CE, Xiu J, Bilen MA, Case KB, Tinsley M, Carthon B, Harik LR
Archives of pathology & laboratory medicine 2024 Mar 1;148(3):310-317
Archives of pathology & laboratory medicine 2024 Mar 1;148(3):310-317
Mammalian IRE1α dynamically and functionally coalesces with stress granules.
Liu S, Zhang X, Yao X, Wang G, Huang S, Chen P, Tang M, Cai J, Wu Z, Zhang Y, Xu R, Liu K, He K, Wang Y, Jiang L, Wang QA, Rui L, Liu J, Liu Y
Nature cell biology 2024 Jun;26(6):917-931
Nature cell biology 2024 Jun;26(6):917-931
LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.
Li M, Hou Y, Zhou Y, Yang Z, Zhao H, Jian T, Yu Q, Zeng F, Liu X, Zhang Z, Zhao YG
The Journal of cell biology 2024 Jun 3;223(6)
The Journal of cell biology 2024 Jun 3;223(6)
Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X.
Zhang X, Han L, Hou J, Yang H, Xu H, Li G, Shu Q, Zhu D, Zheng Y, Gao C
Cell reports 2024 Jun 25;43(6):114248
Cell reports 2024 Jun 25;43(6):114248
Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies.
Robinson JL, Suh E, Xu Y, Hurtig HI, Elman L, McMillan CT, Irwin DJ, Porta S, Van Deerlin VM, Lee EB
Acta neuropathologica 2024 Jun 19;147(1):104
Acta neuropathologica 2024 Jun 19;147(1):104
The mRNA-capping enzyme localizes to stress granules in the cytoplasm and maintains cap homeostasis of target mRNAs.
Gayen A, Mukherjee A, Kumar K, Majumder S, Chakrabarti S, Mukherjee C
Journal of cell science 2024 Jun 1;137(11)
Journal of cell science 2024 Jun 1;137(11)
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress.
Shi W, Ding R, Chen Y, Ji F, Ji J, Ma W, Jin J
iScience 2024 Jul 19;27(7):110196
iScience 2024 Jul 19;27(7):110196
A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation.
Wang Q, Kohls W, Wills M, Li F, Pang Q, Geng X, Ding Y
CNS neuroscience & therapeutics 2024 Jan;30(1):e14405
CNS neuroscience & therapeutics 2024 Jan;30(1):e14405
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Wang Y, She S, Li W, Zhu J, Li X, Yang F, Dai K
Molecular immunology 2024 Jan;165:42-54
Molecular immunology 2024 Jan;165:42-54
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Lin N, Sun L, Chai J, Qi H, Zhao Y, Ma J, Xia M, Hu X
Cancer cell international 2024 Jan 18;24(1):38
Cancer cell international 2024 Jan 18;24(1):38
Dynamic proximity interaction profiling suggests that YPEL2 is involved in cellular stress surveillance.
Turan G, Olgun ÇE, Ayten H, Toker P, Ashyralyyev A, Savaş B, Karaca E, Muyan M
Protein science : a publication of the Protein Society 2024 Feb;33(2):e4859
Protein science : a publication of the Protein Society 2024 Feb;33(2):e4859
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M
EMBO reports 2024 Feb;25(2):672-703
EMBO reports 2024 Feb;25(2):672-703
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
Zheng X, Chen J, Deng M, Ning K, Peng Y, Liu Z, Li X, Zhou Z, Tang H, Li Y, Kang T, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress.
Liboy-Lugo JM, Espinoza CA, Sheu-Gruttadauria J, Park JE, Xu A, Jowhar Z, Gao AL, Carmona-Negrón JA, Wittmann T, Jura N, Floor SN
bioRxiv : the preprint server for biology 2024 Feb 7;
bioRxiv : the preprint server for biology 2024 Feb 7;
Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex.
Zhang Q, Xian W, Li Z, Lu Q, Chen X, Ge J, Tang Z, Liu B, Chen Z, Gao X, Hottiger MO, Zhang P, Qiu J, Shao F, Liu X
Cell reports 2024 Feb 27;43(2):113789
Cell reports 2024 Feb 27;43(2):113789
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769
Cell reports 2024 Feb 27;43(2):113769
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
Yang C, Leifer C, Lammerding J, Hu F
The Journal of biological chemistry 2024 Dec;300(12):107999
The Journal of biological chemistry 2024 Dec;300(12):107999
The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.
Yang PY, Yang Z, Lv J, Jiang PY, Quan TQ, Huang ZH, Xu XD, Guo R, Wei D, Sun Y
The Journal of biological chemistry 2024 Dec;300(12):107964
The Journal of biological chemistry 2024 Dec;300(12):107964
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination.
Jeon P, Ham HJ, Choi H, Park S, Jang JW, Park SW, Cho DH, Lee HJ, Song HK, Komatsu M, Han D, Jang DJ, Lee JA
Nature communications 2024 Dec 30;15(1):10925
Nature communications 2024 Dec 30;15(1):10925
Stress granules play a critical role in hexavalent chromium-induced malignancy in a G3BP1 dependent manner.
Shaw B, Thwin PH, Jia N, Weng H, Ma C, Zhu H, Wang L
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124997
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124997
Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome.
Cai J, Li C, Liu S, Tan M, Sun Y, Sun X, Yang M, He B
Cell death and differentiation 2024 Aug;31(8):1057-1069
Cell death and differentiation 2024 Aug;31(8):1057-1069
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
Ou N, Wang Y, Xu S, Luo J, Zhang C, Zhang Y, Shi X, Xiong M, Zhao L, Ji Z, Zhang Y, Zhao J, Bai H, Tian R, Li P, Zhi E, Huang Y, Chen W, Wang R, Jin Y, Wang D, Li Z, Chen H, Yao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network.
Yao Z, Liu Y, Chen Q, Chen X, Zhu Z, Song S, Ma X, Yang P
Cell reports 2024 Aug 27;43(8):114617
Cell reports 2024 Aug 27;43(8):114617
The Raf kinase inhibitors Dabrafenib and Regorafenib impair Zika virus replication via distinct mechanisms.
Wilken L, Rimmelzwaan GF, Elbahesh H
Journal of virology 2024 Aug 20;98(8):e0061824
Journal of virology 2024 Aug 20;98(8):e0061824
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.
Maneix L, Iakova P, Lee CG, Moree SE, Lu X, Datar GK, Hill CT, Spooner E, King JCK, Sykes DB, Saez B, Di Stefano B, Chen X, Krause DS, Sahin E, Tsai FTF, Goodell MA, Berk BC, Scadden DT, Catic A
Nature cell biology 2024 Apr;26(4):593-603
Nature cell biology 2024 Apr;26(4):593-603
Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis.
Pisciottani A, Croci L, Lauria F, Marullo C, Savino E, Ambrosi A, Podini P, Marchioretto M, Casoni F, Cremona O, Taverna S, Quattrini A, Cioni JM, Viero G, Codazzi F, Consalez GG
Frontiers in cellular neuroscience 2023;17:1253543
Frontiers in cellular neuroscience 2023;17:1253543
Identification and validation of a novel stress granules-related prognostic model in colorectal cancer.
Liu Z, Zhao E, Li H, Lin D, Huang C, Zhou Y, Zhang Y, Pan X, Liao W, Li F
Frontiers in genetics 2023;14:1105368
Frontiers in genetics 2023;14:1105368
TRIM25-mediated ubiquitination of G3BP1 regulates the proliferation and migration of human neuroblastoma cells.
Yang Y, Luo Y, Yang C, Hu R, Qin X, Li C
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Sep;1866(3):194954
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Sep;1866(3):194954
Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation.
Wang C, Terrigno M, Li J, Distler T, Pandya NJ, Ebeling M, Tyanova S, Hoozemans JJM, Dijkstra AA, Fuchs L, Xiang S, Bonni A, Grüninger F, Jagasia R
Neuron 2023 Sep 6;111(17):2660-2674.e9
Neuron 2023 Sep 6;111(17):2660-2674.e9
Rosmarinic acid ameliorates autoimmune responses through suppression of intracellular nucleic acid-mediated type I interferon expression.
Li XW, Yuan SC, Wang M, Su ZH, Zhao M, Li T, Zhang XM, Xue W, Li WH
Biochemical and biophysical research communications 2023 Sep 17;673:73-80
Biochemical and biophysical research communications 2023 Sep 17;673:73-80
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
Hwang HJ, Park TL, Kim HI, Park Y, Kim G, Song C, Cho WK, Kim YK
Nature communications 2023 Oct 6;14(1):6248
Nature communications 2023 Oct 6;14(1):6248
Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis.
Ge Y, Jin J, Chen G, Li J, Ye M, Jin X
Cell communication and signaling : CCS 2023 Oct 30;21(1):303
Cell communication and signaling : CCS 2023 Oct 30;21(1):303
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921
Redox biology 2023 Nov;67:102921
Stress granules plug and stabilize damaged endolysosomal membranes.
Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG
Nature 2023 Nov;623(7989):1062-1069
Nature 2023 Nov;623(7989):1062-1069
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y, He C, Lin S
Nature cell biology 2023 Nov;25(11):1676-1690
Nature cell biology 2023 Nov;25(11):1676-1690
Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer.
Liu C, Zhou L, Chen J, Yang Z, Chen S, Wang X, Liu X, Li Y, Zhang C, Wang Y, Chen Y, Li H, Shen C, Sun H
Biochemical pharmacology 2023 Nov;217:115834
Biochemical pharmacology 2023 Nov;217:115834
Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis.
Yang T, Wang G, Zhang M, Hu X, Li Q, Yun F, Xing Y, Song X, Zhang H, Hu G, Qian Y
Cell reports 2023 Nov 28;42(11):113377
Cell reports 2023 Nov 28;42(11):113377
Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.
Hu S, Zhang Y, Yi Q, Yang C, Liu Y, Bai Y
Nature communications 2023 Nov 27;14(1):7782
Nature communications 2023 Nov 27;14(1):7782
Molecular Graph-Based Deep Learning Algorithm Facilitates an Imaging-Based Strategy for Rapid Discovery of Small Molecules Modulating Biomolecular Condensates.
Gao P, Zhang Q, Keely D, Cleveland DW, Ye Y, Zheng W, Shen M, Yu H
Journal of medicinal chemistry 2023 Nov 23;66(22):15084-15093
Journal of medicinal chemistry 2023 Nov 23;66(22):15084-15093
Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases.
Fujikawa D, Nakamura T, Yoshioka D, Li Z, Moriizumi H, Taguchi M, Tokai-Nishizumi N, Kozuka-Hata H, Oyama M, Takekawa M
Current biology : CB 2023 May 22;33(10):1967-1981.e8
Current biology : CB 2023 May 22;33(10):1967-1981.e8
In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.
Vujovic A, de Rooij L, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ
Blood cancer discovery 2023 May 1;4(3):180-207
Blood cancer discovery 2023 May 1;4(3):180-207
circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR.
Liu J, Niu L, Hao J, Yao Y, Yan M, Li H
Oncogene 2023 Mar;42(13):980-993
Oncogene 2023 Mar;42(13):980-993
ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation.
Zhang J, Zhou EC, He Y, Chai ZL, Ji BZ, Tu Y, Wang HL, Wu WQ, Liu Y, Zhang XH, Liu Y
Cell reports 2023 Mar 28;42(3):112278
Cell reports 2023 Mar 28;42(3):112278
The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.
Curdy N, Lanvin O, Cerapio JP, Pont F, Tosolini M, Sarot E, Valle C, Saint-Laurent N, Lhuillier E, Laurent C, Fournié JJ, Franchini DM
Cell reports 2023 Mar 28;42(3):112211
Cell reports 2023 Mar 28;42(3):112211
Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules.
McGoldrick P, Lau A, You Z, Durcan TM, Robertson J
Cell reports 2023 Mar 28;42(3):112134
Cell reports 2023 Mar 28;42(3):112134
The ZSWIM8 ubiquitin ligase regulates neurodevelopment by guarding the protein quality of intrinsically disordered Dab1.
Wang G, Lei J, Wang Y, Yu J, He Y, Zhao W, Hu Z, Xu Z, Jin Y, Gu Y, Guo X, Yang B, Gao Z, Wang Z
Cerebral cortex (New York, N.Y. : 1991) 2023 Mar 21;33(7):3866-3881
Cerebral cortex (New York, N.Y. : 1991) 2023 Mar 21;33(7):3866-3881
Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43.
Keating SS, Bademosi AT, San Gil R, Walker AK
Cellular and molecular life sciences : CMLS 2023 Mar 17;80(4):95
Cellular and molecular life sciences : CMLS 2023 Mar 17;80(4):95
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.
Szczerba M, Johnson B, Acciai F, Gogerty C, McCaughan M, Williams J, Kibler KV, Jacobs BL
Science signaling 2023 Mar 14;16(776):eabq0837
Science signaling 2023 Mar 14;16(776):eabq0837
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.
Cervia LD, Shibue T, Borah AA, Gaeta B, He L, Leung L, Li N, Moyer SM, Shim BH, Dumont N, Gonzalez A, Bick NR, Kazachkova M, Dempster JM, Krill-Burger JM, Piccioni F, Udeshi ND, Olive ME, Carr SA, Root DE, McFarland JM, Vazquez F, Hahn WC
Cancer discovery 2023 Mar 1;13(3):766-795
Cancer discovery 2023 Mar 1;13(3):766-795
Stress granules affect the sensitivity of renal cancer cells to sorafenib by sequestering and stabilizing COX‑2 mRNA.
Dai H, Wang G, Cao W, Qi W, Chen W, Guo H
Oncology letters 2023 Jun;25(6):274
Oncology letters 2023 Jun;25(6):274
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvardo RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP
bioRxiv : the preprint server for biology 2023 Jun 30;
bioRxiv : the preprint server for biology 2023 Jun 30;
Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges.
Miyagi T, Ueda K, Sugimoto M, Yagi T, Ito D, Yamazaki R, Narumi S, Hayamizu Y, Uji-I H, Kuroda M, Kanekura K
iScience 2023 Jun 16;26(6):106957
iScience 2023 Jun 16;26(6):106957
African swine fever virus pS273R antagonizes stress granule formation by cleaving the nucleating protein G3BP1 to facilitate viral replication.
Li T, Li X, Wang X, Chen X, Zhao G, Liu C, Bao M, Song J, Li J, Huang L, Rong J, Tian K, Deng J, Zhu J, Cai X, Bu Z, Zheng J, Weng C
The Journal of biological chemistry 2023 Jul;299(7):104844
The Journal of biological chemistry 2023 Jul;299(7):104844
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y
Autophagy 2023 Jul;19(7):1934-1951
Autophagy 2023 Jul;19(7):1934-1951
QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.
Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J
Cell 2023 Jul 20;186(15):3208-3226.e27
Cell 2023 Jul 20;186(15):3208-3226.e27
Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia.
Antoniani F, Cimino M, Mediani L, Vinet J, Verde EM, Secco V, Yamoah A, Tripathi P, Aronica E, Cicardi ME, Trotti D, Sterneckert J, Goswami A, Carra S
Cell death discovery 2023 Jul 15;9(1):248
Cell death discovery 2023 Jul 15;9(1):248
TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.
Kitajima H, Maruyama R, Niinuma T, Yamamoto E, Takasawa A, Takasawa K, Ishiguro K, Tsuyada A, Suzuki R, Sudo G, Kubo T, Mitsuhashi K, Idogawa M, Tange S, Toyota M, Yoshido A, Kumegawa K, Kai M, Yanagihara K, Tokino T, Osanai M, Nakase H, Suzuki H
Cell death & disease 2023 Jul 13;14(7):424
Cell death & disease 2023 Jul 13;14(7):424
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Dubinski A, Gagné M, Peyrard S, Gordon D, Talbot K, Vande Velde C
Human molecular genetics 2023 Jan 6;32(2):319-332
Human molecular genetics 2023 Jan 6;32(2):319-332
Integrative genetic analysis illuminates ALS heritability and identifies risk genes.
Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH, Project Mine Als Sequencing Consortium, Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L
Nature communications 2023 Jan 20;14(1):342
Nature communications 2023 Jan 20;14(1):342
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
Li WY, Yang F, Li X, Wang LW, Wang Y
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.
Asamitsu S, Yabuki Y, Matsuo K, Kawasaki M, Hirose Y, Kashiwazaki G, Chandran A, Bando T, Wang DO, Sugiyama H, Shioda N
Science advances 2023 Feb 24;9(8):eade2035
Science advances 2023 Feb 24;9(8):eade2035
Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
Cui Q, Bi H, Lv Z, Wu Q, Hua J, Gu B, Huo C, Tang M, Chen Y, Chen C, Chen S, Zhang X, Wu Z, Lao Z, Sheng N, Shen C, Zhang Y, Wu ZY, Jin Z, Yang P, Liu H, Li J, Bai G
Cell 2023 Feb 16;186(4):803-820.e25
Cell 2023 Feb 16;186(4):803-820.e25
Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis.
Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166835
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166835
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Lu D, Liu Y, Huang H, Hu M, Li T, Wang S, Shen S, Wu R, Cai W, Lu T, Lu Z
Translational stroke research 2023 Dec;14(6):910-928
Translational stroke research 2023 Dec;14(6):910-928
SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.
Li Y, Bie J, Song C, Li Y, Zhang T, Li H, Zhao L, You F, Luo J
EMBO reports 2023 Dec 6;24(12):e57500
EMBO reports 2023 Dec 6;24(12):e57500
LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, Okano H, Toda T, Nakanishi M
Nature aging 2023 Aug;3(8):1001-1019
Nature aging 2023 Aug;3(8):1001-1019
Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure.
Li W, Li W, Li X, Wang L, Wang Y
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1226-1240
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1226-1240
Screening Linear and Circular RNA Transcripts from Stress Granules.
Chen S, Zhang J, Zhao F
Genomics, proteomics & bioinformatics 2023 Aug;21(4):886-893
Genomics, proteomics & bioinformatics 2023 Aug;21(4):886-893
Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor-associated macrophages.
Tong F, Hu H, Xu Y, Zhou Y, Xie R, Lei T, Du Y, Yang W, He S, Huang Y, Gong T, Gao H
Acta pharmaceutica Sinica. B 2023 Aug;13(8):3471-3488
Acta pharmaceutica Sinica. B 2023 Aug;13(8):3471-3488
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.
Park J, Wu Y, Shao W, Gendron TF, van der Spek SJF, Sultanakhmetov G, Basu A, Castellanos Otero P, Jones CJ, Jansen-West K, Daughrity LM, Phanse S, Del Rosso G, Tong J, Castanedes-Casey M, Jiang L, Libera J, Oskarsson B, Dickson DW, Sanders DW, Brangwynne CP, Emili A, Wolozin B, Petrucelli L, Zhang YJ
Cell reports 2023 Aug 29;42(8):112822
Cell reports 2023 Aug 29;42(8):112822
Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.
Tong L, Rao J, Yang C, Xu J, Lu Y, Zhang Y, Cang X, Xie S, Mao J, Jiang P
iScience 2023 Aug 18;26(8):107446
iScience 2023 Aug 18;26(8):107446
Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
Cai S, Zhang C, Zhuang Z, Zhang S, Ma L, Yang S, Zhou T, Wang Z, Xie W, Jin S, Zhao J, Guan X, Wu J, Cui J, Wu Y
Signal transduction and targeted therapy 2023 Apr 26;8(1):170
Signal transduction and targeted therapy 2023 Apr 26;8(1):170
Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome.
Geng J, Khaket TP, Pan J, Li W, Zhang Y, Ping Y, Cobos Sillero MI, Lu B
Developmental cell 2023 Apr 10;58(7):597-615.e10
Developmental cell 2023 Apr 10;58(7):597-615.e10
C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Zheng W, Wang K, Wu Y, Yan G, Zhang C, Li Z, Wang L, Chen S
Theranostics 2022;12(17):7289-7306
Theranostics 2022;12(17):7289-7306
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
Xu H, Bensalel J, Capobianco E, Lu ML, Wei J
Cellular and molecular neurobiology 2022 Nov;42(8):2757-2771
Cellular and molecular neurobiology 2022 Nov;42(8):2757-2771
RNA supply drives physiological granule assembly in neurons.
Bauer KE, Bargenda N, Schieweck R, Illig C, Segura I, Harner M, Kiebler MA
Nature communications 2022 May 19;13(1):2781
Nature communications 2022 May 19;13(1):2781
Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS.
Tsai YL, Mu YC, Manley JL
Scientific reports 2022 May 17;12(1):8180
Scientific reports 2022 May 17;12(1):8180
CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.
Song X, Chen B, Liang Y, Li Y, Zhang H, Han D, Wang Y, Ye F, Wang L, Zhao W, Yang Q
Cell death discovery 2022 May 14;8(1):261
Cell death discovery 2022 May 14;8(1):261
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy.
Hwang HJ, Ha H, Lee BS, Kim BH, Song HK, Kim YK
Nature communications 2022 Mar 17;13(1):1436
Nature communications 2022 Mar 17;13(1):1436
The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm.
Kirchhof L, Fouani Y, Knau A, Aslan GS, Heumüller AW, Wittig I, Müller-McNicoll M, Dimmeler S, Jaé N
Non-coding RNA 2022 Jun 30;8(4)
Non-coding RNA 2022 Jun 30;8(4)
Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells.
Gao YY, Zhong T, Wang LQ, Zhang N, Zeng Y, Hu JY, Dang HB, Chen J, Liang Y
International journal of biological macromolecules 2022 Jun 1;209(Pt A):703-715
International journal of biological macromolecules 2022 Jun 1;209(Pt A):703-715
cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium.
Li J, Zhang F, Bian W, Chen Y, Liu J, Liu Z, Xiong Y, Wan X
Cell & bioscience 2022 Jul 25;12(1):116
Cell & bioscience 2022 Jul 25;12(1):116
Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation.
Shen H, Yanas A, Owens MC, Zhang C, Fritsch C, Fare CM, Copley KE, Shorter J, Goldman YE, Liu KF
Molecular cell 2022 Jul 21;82(14):2588-2603.e9
Molecular cell 2022 Jul 21;82(14):2588-2603.e9
Viral evasion of PKR restriction by reprogramming cellular stress granules.
Gao P, Liu Y, Wang H, Chai Y, Weng W, Zhang Y, Zhou L, Ge X, Guo X, Han J, Yang H
Proceedings of the National Academy of Sciences of the United States of America 2022 Jul 19;119(29):e2201169119
Proceedings of the National Academy of Sciences of the United States of America 2022 Jul 19;119(29):e2201169119
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules.
Zheng Y, Deng J, Han L, Zhuang MW, Xu Y, Zhang J, Nan ML, Xiao Y, Zhan P, Liu X, Gao C, Wang PH
Signal transduction and targeted therapy 2022 Jan 24;7(1):22
Signal transduction and targeted therapy 2022 Jan 24;7(1):22
MxB inhibits long interspersed element type 1 retrotransposition.
Huang Y, Xu F, Mei S, Liu X, Zhao F, Wei L, Fan Z, Hu Y, Wang L, Ai B, Cen S, Liang C, Guo F
PLoS genetics 2022 Feb;18(2):e1010034
PLoS genetics 2022 Feb;18(2):e1010034
Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1.
Yang F, Li L, Mu Z, Liu P, Wang Y, Zhang Y, Han X
Cancer gene therapy 2022 Dec;29(12):1939-1950
Cancer gene therapy 2022 Dec;29(12):1939-1950
c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation.
Lee S, Ryu HG, Kweon SH, Kim H, Park H, Lee KH, Jang SM, Na CH, Kim S, Ko HS
Cells 2022 Dec 8;11(24)
Cells 2022 Dec 8;11(24)
Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.
Johnson MA, Nuckols TA, Merino P, Bagchi P, Nandy S, Root J, Taylor G, Seyfried NT, Kukar T
The Journal of biological chemistry 2022 Aug;298(8):102135
The Journal of biological chemistry 2022 Aug;298(8):102135
Upregulated LINC01088 facilitates malignant phenotypes and immune escape of colorectal cancer by regulating microRNAs/G3BP1/PD-L1 axis.
Li C, Pan B, Wang X, Liu X, Qin J, Gao T, Sun H, Pan Y, Wang S
Journal of cancer research and clinical oncology 2022 Aug;148(8):1965-1982
Journal of cancer research and clinical oncology 2022 Aug;148(8):1965-1982
ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain-of-function.
Pant DC, Parameswaran J, Rao L, Loss I, Chilukuri G, Parlato R, Shi L, Glass JD, Bassell GJ, Koch P, Yilmaz R, Weishaupt JH, Gennerich A, Jiang J
EMBO reports 2022 Aug 3;23(8):e54234
EMBO reports 2022 Aug 3;23(8):e54234
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
Gruijs da Silva LA, Simonetti F, Hutten S, Riemenschneider H, Sternburg EL, Pietrek LM, Gebel J, Dötsch V, Edbauer D, Hummer G, Stelzl LS, Dormann D
The EMBO journal 2022 Apr 19;41(8):e108443
The EMBO journal 2022 Apr 19;41(8):e108443
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.
Lenard AJ, Hutten S, Zhou Q, Usluer S, Zhang F, Bourgeois BMR, Dormann D, Madl T
Frontiers in molecular biosciences 2021;8:689687
Frontiers in molecular biosciences 2021;8:689687
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Alfred N, Qian B, Qin X, Yin X, Prajapati M, Dou Y, Li Y, Zhang Z
Frontiers in veterinary science 2021;8:645571
Frontiers in veterinary science 2021;8:645571
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner.
Fortuna TR, Kour S, Anderson EN, Ward C, Rajasundaram D, Donnelly CJ, Hermann A, Wyne H, Shewmaker F, Pandey UB
Acta neuropathologica 2021 Sep;142(3):515-536
Acta neuropathologica 2021 Sep;142(3):515-536
Orf Virus ORF120 Protein Positively Regulates the NF-κB Pathway by Interacting with G3BP1.
Zhou Y, Guan J, Gao F, Li Z, Lan Y, Lu H, Song D, Lv L, Lv P, Xu M, Wang Z, He H, Zhao K, He W
Journal of virology 2021 Sep 9;95(19):e0015321
Journal of virology 2021 Sep 9;95(19):e0015321
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
Dai B, Zhong T, Chen ZX, Chen W, Zhang N, Liu XL, Wang LQ, Chen J, Liang Y
The Journal of biological chemistry 2021 Oct;297(4):101222
The Journal of biological chemistry 2021 Oct;297(4):101222
c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA.
Li B, Zhang G, Wang Z, Yang Y, Wang C, Fang D, Liu K, Wang F, Mei Y
Cell death & disease 2021 Oct 27;12(11):1006
Cell death & disease 2021 Oct 27;12(11):1006
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Park J, Lee J, Kim JH, Lee J, Park H, Lim C
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells.
Yu NK, McClatchy DB, Diedrich JK, Romero S, Choi JH, Martínez-Bartolomé S, Delahunty CM, Muotri AR, Yates JR 3rd
iScience 2021 Nov 19;24(11):103321
iScience 2021 Nov 19;24(11):103321
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.
Zhang M, Yang C, Zhu M, Qian L, Luo Y, Cheng H, Geng R, Xu X, Qian C, Liu Y
Diabetologia 2021 May;64(5):1144-1157
Diabetologia 2021 May;64(5):1144-1157
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Xue YC, Ng CS, Mohamud Y, Fung G, Liu H, Bahreyni A, Zhang J, Luo H
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection.
Ciccosanti F, Di Rienzo M, Romagnoli A, Colavita F, Refolo G, Castilletti C, Agrati C, Brai A, Manetti F, Botta L, Capobianchi MR, Ippolito G, Piacentini M, Fimia GM
Antiviral research 2021 Jun;190:105064
Antiviral research 2021 Jun;190:105064
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production.
Luo L, Li Z, Zhao T, Ju X, Ma P, Jin B, Zhou Y, He S, Huang J, Xu X, Zou Y, Li P, Liang A, Liu J, Chi T, Huang X, Ding Q, Jin Z, Huang C, Zhang Y
Science bulletin 2021 Jun 30;66(12):1194-1204
Science bulletin 2021 Jun 30;66(12):1194-1204
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly.
Samir P, Place DE, Malireddi RKS, Kanneganti TD
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 1;207(1):115-124
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 1;207(1):115-124
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
Baade I, Hutten S, Sternburg EL, Pörschke M, Hofweber M, Dormann D, Kehlenbach RH
The Journal of biological chemistry 2021 Jan-Jun;296:100659
The Journal of biological chemistry 2021 Jan-Jun;296:100659
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
Kesavardhana S, Samir P, Zheng M, Malireddi RKS, Karki R, Sharma BR, Place DE, Briard B, Vogel P, Kanneganti TD
The Journal of biological chemistry 2021 Jan-Jun;296:100579
The Journal of biological chemistry 2021 Jan-Jun;296:100579
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD
Nature structural & molecular biology 2021 Feb;28(2):132-142
Nature structural & molecular biology 2021 Feb;28(2):132-142
The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins.
Park J, Chang J, Hwang HJ, Jeong K, Lee HJ, Ha H, Park Y, Lim C, Woo JS, Kim YK
Nucleic acids research 2021 Dec 2;49(21):12517-12534
Nucleic acids research 2021 Dec 2;49(21):12517-12534
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Sidibé H, Khalfallah Y, Xiao S, Gómez NB, Fakim H, Tank EMH, Di Tomasso G, Bareke E, Aulas A, McKeever PM, Melamed Z, Destroimaisons L, Deshaies JE, Zinman L, Parker JA, Legault P, Tétreault M, Barmada SJ, Robertson J, Vande Velde C
Brain : a journal of neurology 2021 Dec 16;144(11):3461-3476
Brain : a journal of neurology 2021 Dec 16;144(11):3461-3476
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S
Cell 2021 Aug 19;184(17):4547-4563.e17
Cell 2021 Aug 19;184(17):4547-4563.e17
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78
Frontiers in microbiology 2020;11:78
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Arenas A, Chen J, Kuang L, Barnett KR, Kasarskis EJ, Gal J, Zhu H
Human molecular genetics 2020 Sep 29;29(16):2684-2697
Human molecular genetics 2020 Sep 29;29(16):2684-2697
Rapid prediction of drug inhibition under heat stress: single-photon imaging combined with a convolutional neural network.
Lin H, Xie J, Fan T, He Y, Chen J, Zhang H, Zhuo S
Nanoscale 2020 Nov 26;12(45):23134-23139
Nanoscale 2020 Nov 26;12(45):23134-23139
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Capturing RNA-protein interaction via CRUIS.
Zhang Z, Sun W, Shi T, Lu P, Zhuang M, Liu JL
Nucleic acids research 2020 May 21;48(9):e52
Nucleic acids research 2020 May 21;48(9):e52
Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases?
Hoch-Kraft P, Trotter J, Gonsior C
Neurochemical research 2020 Mar;45(3):566-579
Neurochemical research 2020 Mar;45(3):566-579
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
Cheng J, Gao S, Zhu C, Liu S, Li J, Kang J, Wang Z, Wang T
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, Peng B, He X, Liu W
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells.
Hicks DA, Cross LL, Williamson R, Rattray M
Neurochemical research 2020 Jun;45(6):1354-1364
Neurochemical research 2020 Jun;45(6):1354-1364
Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis.
Luotti S, Pasetto L, Porcu L, Torri V, Elezgarai SR, Pantalone S, Filareti M, Corbo M, Lunetta C, Mora G, Bonetto V
Neurobiology of disease 2020 Jun;139:104815
Neurobiology of disease 2020 Jun;139:104815
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.
Lo LH, Dong R, Lyu Q, Lai KO
Cell reports 2020 Jun 9;31(10):107744
Cell reports 2020 Jun 9;31(10):107744
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
Rao L, Xu Y, Reineke LC, Bhattacharya A, Tyryshkin A, Shin JN, Eissa NT
International journal of molecular sciences 2020 Jun 17;21(12)
International journal of molecular sciences 2020 Jun 17;21(12)
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
Tsai YL, Coady TH, Lu L, Zheng D, Alland I, Tian B, Shneider NA, Manley JL
Genes & development 2020 Jun 1;34(11-12):785-805
Genes & development 2020 Jun 1;34(11-12):785-805
ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics.
Lee DY, Jeon GS, Sung JJ
Neurochemical research 2020 Dec;45(12):2884-2893
Neurochemical research 2020 Dec;45(12):2884-2893
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
Lee J, Park J, Kim JH, Lee G, Park TE, Yoon KJ, Kim YK, Lim C
PLoS biology 2020 Dec;18(12):e3001002
PLoS biology 2020 Dec;18(12):e3001002
A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptidesin Semi-permeabilized Human Cells.
Hutten S, Dormann D
Bio-protocol 2020 Dec 20;10(24):e3846
Bio-protocol 2020 Dec 20;10(24):e3846
G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer.
Xiong R, Gao JL, Yin T
OncoTargets and therapy 2019;12:7149-7156
OncoTargets and therapy 2019;12:7149-7156
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
Liao YC, Fernandopulle MS, Wang G, Choi H, Hao L, Drerup CM, Patel R, Qamar S, Nixon-Abell J, Shen Y, Meadows W, Vendruscolo M, Knowles TPJ, Nelson M, Czekalska MA, Musteikyte G, Gachechiladze MA, Stephens CA, Pasolli HA, Forrest LR, St George-Hyslop P, Lippincott-Schwartz J, Ward ME
Cell 2019 Sep 19;179(1):147-164.e20
Cell 2019 Sep 19;179(1):147-164.e20
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
Gal J, Chen J, Na DY, Tichacek L, Barnett KR, Zhu H
Molecular and cellular biology 2019 Nov 15;39(22)
Molecular and cellular biology 2019 Nov 15;39(22)
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM, Pruett-Miller SM, Bertorini T, Vogel P, Kim HJ, Peng J, Taylor JP, Kundu M
Molecular cell 2019 May 16;74(4):742-757.e8
Molecular cell 2019 May 16;74(4):742-757.e8
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
Tischbein M, Baron DM, Lin YC, Gall KV, Landers JE, Fallini C, Bosco DA
The Journal of biological chemistry 2019 Jun 28;294(26):10194-10210
The Journal of biological chemistry 2019 Jun 28;294(26):10194-10210
m(6)A enhances the phase separation potential of mRNA.
Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR
Nature 2019 Jul;571(7765):424-428
Nature 2019 Jul;571(7765):424-428
Lysine/RNA-interactions drive and regulate biomolecular condensation.
Ukmar-Godec T, Hutten S, Grieshop MP, Rezaei-Ghaleh N, Cima-Omori MS, Biernat J, Mandelkow E, Söding J, Dormann D, Zweckstetter M
Nature communications 2019 Jul 2;10(1):2909
Nature communications 2019 Jul 2;10(1):2909
Stress granules are formed in renal proximal tubular cells during metabolic stress and ischemic injury for cell survival.
Wang S, Kwon SH, Su Y, Dong Z
American journal of physiology. Renal physiology 2019 Jul 1;317(1):F116-F123
American journal of physiology. Renal physiology 2019 Jul 1;317(1):F116-F123
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Baron DM, Matheny T, Lin YC, Leszyk JD, Kenna K, Gall KV, Santos DP, Tischbein M, Funes S, Hayward LJ, Kiskinis E, Landers JE, Parker R, Shaffer SA, Bosco DA
Human molecular genetics 2019 Jul 1;28(13):2143-2160
Human molecular genetics 2019 Jul 1;28(13):2143-2160
STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.
Ye C, Yu Z, Xiong Y, Wang Y, Ruan Y, Guo Y, Chen M, Luan S, Zhang E, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):286-300
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):286-300
G3BP1 promotes DNA binding and activation of cGAS.
Liu ZS, Cai H, Xue W, Wang M, Xia T, Li WJ, Xing JQ, Zhao M, Huang YJ, Chen S, Wu SM, Wang X, Liu X, Pang X, Zhang ZY, Li T, Dai J, Dong F, Xia Q, Li AL, Zhou T, Liu ZG, Zhang XM, Li T
Nature immunology 2019 Jan;20(1):18-28
Nature immunology 2019 Jan;20(1):18-28
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.
Franchini DM, Lanvin O, Tosolini M, Patras de Campaigno E, Cammas A, Péricart S, Scarlata CM, Lebras M, Rossi C, Ligat L, Pont F, Arimondo PB, Laurent C, Ayyoub M, Despas F, Lapeyre-Mestre M, Millevoi S, Fournié JJ
Cell reports 2019 Jan 2;26(1):94-107.e7
Cell reports 2019 Jan 2;26(1):94-107.e7
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression.
Cai D, Feliciano D, Dong P, Flores E, Gruebele M, Porat-Shliom N, Sukenik S, Liu Z, Lippincott-Schwartz J
Nature cell biology 2019 Dec;21(12):1578-1589
Nature cell biology 2019 Dec;21(12):1578-1589
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB
Nature communications 2019 Dec 6;10(1):5583
Nature communications 2019 Dec 6;10(1):5583
Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology.
Silva JM, Rodrigues S, Sampaio-Marques B, Gomes P, Neves-Carvalho A, Dioli C, Soares-Cunha C, Mazuik BF, Takashima A, Ludovico P, Wolozin B, Sousa N, Sotiropoulos I
Cell death and differentiation 2019 Aug;26(8):1411-1427
Cell death and differentiation 2019 Aug;26(8):1411-1427
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ
Neuron 2019 Apr 17;102(2):321-338.e8
Neuron 2019 Apr 17;102(2):321-338.e8
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Herrmann A, Wittmann S, Thomas D, Shepard CN, Kim B, Ferreirós N, Gramberg T
Mobile DNA 2018;9:11
Mobile DNA 2018;9:11
O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.
Zhang X, Shu XE, Qian SB
Nature chemical biology 2018 Oct;14(10):909-916
Nature chemical biology 2018 Oct;14(10):909-916
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.
Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach RH, Bailer SM, Dormann D
Scientific reports 2018 May 4;8(1):7084
Scientific reports 2018 May 4;8(1):7084
A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.
Ramachandran B, Stabley JN, Cheng SL, Behrmann AS, Gay A, Li L, Mead M, Kozlitina J, Lemoff A, Mirzaei H, Chen Z, Towler DA
The Journal of biological chemistry 2018 May 25;293(21):7942-7968
The Journal of biological chemistry 2018 May 25;293(21):7942-7968
TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations.
Lee Y, Jonson PH, Sarparanta J, Palmio J, Sarkar M, Vihola A, Evilä A, Suominen T, Penttilä S, Savarese M, Johari M, Minot MC, Hilton-Jones D, Maddison P, Chinnery P, Reimann J, Kornblum C, Kraya T, Zierz S, Sue C, Goebel H, Azfer A, Ralston SH, Hackman P, Bucelli RC, Taylor JP, Weihl CC, Udd B
The Journal of clinical investigation 2018 Mar 1;128(3):1164-1177
The Journal of clinical investigation 2018 Mar 1;128(3):1164-1177
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
Youn JY, Dunham WH, Hong SJ, Knight JDR, Bashkurov M, Chen GI, Bagci H, Rathod B, MacLeod G, Eng SWM, Angers S, Morris Q, Fabian M, Côté JF, Gingras AC
Molecular cell 2018 Feb 1;69(3):517-532.e11
Molecular cell 2018 Feb 1;69(3):517-532.e11
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D
Cell 2018 Apr 19;173(3):706-719.e13
Cell 2018 Apr 19;173(3):706-719.e13
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Basu M, Courtney SC, Brinton MA
PLoS pathogens 2017 Feb;13(2):e1006240
PLoS pathogens 2017 Feb;13(2):e1006240
Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1.
Reineke LC, Tsai WC, Jain A, Kaelber JT, Jung SY, Lloyd RE
Molecular and cellular biology 2017 Feb 15;37(4)
Molecular and cellular biology 2017 Feb 15;37(4)
De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies.
Mitsuhashi K, Ito D, Mashima K, Oyama M, Takahashi S, Suzuki N
Scientific reports 2017 Dec 4;7(1):16871
Scientific reports 2017 Dec 4;7(1):16871
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
Cifuentes-Muñoz N, Branttie J, Slaughter KB, Dutch RE
Journal of virology 2017 Dec 15;91(24)
Journal of virology 2017 Dec 15;91(24)
Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis.
Kuang L, Kamelgarn M, Arenas A, Gal J, Taylor D, Gong W, Brown M, St Clair D, Kasarskis EJ, Zhu H
Neurology. Genetics 2017 Aug;3(4):e172
Neurology. Genetics 2017 Aug;3(4):e172
G3BP1 contributes to tumor metastasis via upregulation of Slug expression in hepatocellular carcinoma.
Dou N, Chen J, Yu S, Gao Y, Li Y
American journal of cancer research 2016;6(11):2641-2650
American journal of cancer research 2016;6(11):2641-2650
Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.
Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N
Brain : a journal of neurology 2016 Sep;139(Pt 9):2380-94
Brain : a journal of neurology 2016 Sep;139(Pt 9):2380-94
ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.
Gal J, Kuang L, Barnett KR, Zhu BZ, Shissler SC, Korotkov KV, Hayward LJ, Kasarskis EJ, Zhu H
Acta neuropathologica 2016 Oct;132(4):563-76
Acta neuropathologica 2016 Oct;132(4):563-76
Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function.
Orrù S, Coni P, Floris A, Littera R, Carcassi C, Sogos V, Brancia C
Human molecular genetics 2016 Oct 15;25(20):4473-4483
Human molecular genetics 2016 Oct 15;25(20):4473-4483
The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.
Rodriguez-Ortiz CJ, Flores JC, Valenzuela JA, Rodriguez GJ, Zumkehr J, Tran DN, Kimonis VE, Kitazawa M
The American journal of pathology 2016 Jun;186(6):1623-34
The American journal of pathology 2016 Jun;186(6):1623-34
Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.
Xia Q, Wang G, Wang H, Hu Q, Ying Z
Human molecular genetics 2016 Jan 1;25(1):83-96
Human molecular genetics 2016 Jan 1;25(1):83-96
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Daigle JG, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW, Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB
Acta neuropathologica 2016 Apr;131(4):605-20
Acta neuropathologica 2016 Apr;131(4):605-20
Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer.
Deng W, Yan M, Yu T, Ge H, Lin H, Li J, Liu Y, Geng Q, Zhu M, Liu L, He X, Yao M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;35(5):1677-88
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;35(5):1677-88
Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.
Nielsen CT, Østergaard O, Rekvig OP, Sturfelt G, Jacobsen S, Heegaard NH
Lupus 2015 Oct;24(11):1150-60
Lupus 2015 Oct;24(11):1150-60
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G, Ying Z
Human molecular genetics 2015 May 1;24(9):2426-41
Human molecular genetics 2015 May 1;24(9):2426-41
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
Yamakawa M, Ito D, Honda T, Kubo K, Noda M, Nakajima K, Suzuki N
Human molecular genetics 2015 Mar 15;24(6):1630-45
Human molecular genetics 2015 Mar 15;24(6):1630-45
SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.
Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, Pang X, Cen S, Jin Q, Liang C, Guo F
PLoS genetics 2015 Jul;11(7):e1005367
PLoS genetics 2015 Jul;11(7):e1005367
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.
Baron DM, Kaushansky LJ, Ward CL, Sama RR, Chian RJ, Boggio KJ, Quaresma AJ, Nickerson JA, Bosco DA
Molecular neurodegeneration 2013 Aug 31;8:30
Molecular neurodegeneration 2013 Aug 31;8:30
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ, Seyfried NT
PloS one 2012;7(6):e38658
PloS one 2012;7(6):e38658
Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS).
Nihei Y, Ito D, Suzuki N
The Journal of biological chemistry 2012 Nov 30;287(49):41310-23
The Journal of biological chemistry 2012 Nov 30;287(49):41310-23
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Ito D, Seki M, Tsunoda Y, Uchiyama H, Suzuki N
Annals of neurology 2011 Jan;69(1):152-62
Annals of neurology 2011 Jan;69(1):152-62
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
Nishimoto Y, Ito D, Yagi T, Nihei Y, Tsunoda Y, Suzuki N
The Journal of biological chemistry 2010 Jan 1;285(1):608-19
The Journal of biological chemistry 2010 Jan 1;285(1):608-19
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 13057-2-AP(G3BP1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Ethacrynic acid treated HepG2 cells using 13057-2-AP( G3BP1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 13057-2-AP( G3BP1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-G3BP1 (IP:13057-2-AP, 3ug; Detection:13057-2-AP 1:1000) with HEK-293 cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The G3BP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human G3BP1. This antibody recognizes human,mouse,rat antigen. The G3BP1 antibody has been validated for the following applications: ELISA, WB, IP, IF, IHC, FC analysis.
