66486-1-Ig

antibody from Proteintech Group

Targeting: G3BP1 G3BP, HDH-VIII

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66486-1-Ig

Provider

Proteintech Group

Product name

G3BP1 antibody

Antibody type

Monoclonal

Description

G3BP1 antibody (Cat. #66486-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat, pig and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1E4A2

Vial size

20ul, 150ul

References

Submitted references

TRIM25 predominately associates with anti-viral stress granules.

Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau DD, Yang P, Zhang L, Zhou F, Bai P, Jia D
Nature communications 2024 May 15;15(1):4127

---

The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells.

Vicente JJ, Khan K, Tillinghast G, McFaline-Figueroa JL, Sancak Y, Stella N
Journal of translational medicine 2024 May 10;22(1):441

---

HuR-positive stress granules: Potential targets for age-related osteoporosis.

Huai Y, Wang X, Mao W, Wang X, Zhao Y, Chu X, Huang Q, Ru K, Zhang L, Li Y, Chen Z, Qian A
Aging cell 2024 Mar;23(3):e14053

---

A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis.

Liu Q, Wang F, Chen Y, Cui H, Wu H
Journal of hazardous materials 2024 Mar 5;465:133038

---

The Role of Heat-Induced Stress Granules in the Blood-Testis Barrier of Mice.

Zhao Z, Cai Y, Lin X, Liu N, Qin Y, Wu Y
International journal of molecular sciences 2024 Mar 25;25(7)

---

High-throughput and proteome-wide discovery of endogenous biomolecular condensates.

Li P, Chen P, Qi F, Shi J, Zhu W, Li J, Zhang P, Xie H, Li L, Lei M, Ren X, Wang W, Zhang L, Xiang X, Zhang Y, Gao Z, Feng X, Du W, Liu X, Xia L, Liu BF, Li Y
Nature chemistry 2024 Jul;16(7):1101-1112

---

DHX38 enhances proliferation, metastasis, and EMT progression in NSCLC through the G3BP1-mediated MAPK pathway.

Mi K, Zeng L, Chen Y, Ning J, Zhang S, Zhao P, Yang S
Cellular signalling 2024 Jan;113:110962

---

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

Wang F, Wang L, Gan S, Feng S, Ouyang S, Wang X, Yuan S
Research (Washington, D.C.) 2023;6:0091

---

Mitosis exit followed by death in interphase prevents the development of polyploid giant cancer cells.

Vicente JJ, Khan K, Tillinghast G, McFaline-Figueroa JL, Sancak Y, Stella N
bioRxiv : the preprint server for biology 2023 Oct 5;

---

Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways.

Webber CJ, Murphy CN, Rondón-Ortiz AN, van der Spek SJF, Kelly EX, Lampl NM, Chiesa G, Khalil AS, Emili A, Wolozin B
Human molecular genetics 2023 Oct 4;32(20):2966-2980

---

Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.

Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401

---

Stress granules plug and stabilize damaged endolysosomal membranes.

Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG
Nature 2023 Nov;623(7989):1062-1069

---

m(1)A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration.

Sun Y, Dai H, Dai X, Yin J, Cui Y, Liu X, Gonzalez G, Yuan J, Tang F, Wang N, Perlegos AE, Bonini NM, Yang XW, Gu W, Wang Y
Nature 2023 Nov;623(7987):580-587

---

LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.

Chen L, Sun K, Qin W, Huang B, Wu C, Chen J, Lai Q, Wang X, Zhou R, Li A, Liu S, Zhang Y
Cancer letters 2023 Nov 1;576:216420

---

Oleic Acid Dissolves cGAS-DNA Phase Separation to Inhibit Immune Surveillance.

Wang L, Liu Q, Wang N, Li S, Bian W, Sun Z, Wang L, Wang L, Liu C, Song C, Liu Q, Yang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2206820

---

Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.

Wu X, Yang ZH, Wu J, Han J
Immunity 2023 May 9;56(5):926-943.e7

---

Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.

Shi WP, Lin WJ, Ge WY, Chen LL, Zhang TD, Guo WH, Liu JL, Yin DC
Food & function 2023 May 22;14(10):4621-4631

---

The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation.

Feng Z, Mao Z, Yang Z, Liu X, Nakamura F
Journal of cell science 2023 Mar 15;136(6)

---

Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.

Szczerba M, Johnson B, Acciai F, Gogerty C, McCaughan M, Williams J, Kibler KV, Jacobs BL
Science signaling 2023 Mar 14;16(776):eabq0837

---

Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.

Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y
Autophagy 2023 Jul;19(7):1934-1951

---

T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1.

Jiang T, Qi X, Lin R, Jiang J, Wen J, Deng Y
Ecotoxicology and environmental safety 2023 Jul 1;259:115028

---

Atlas of interactions between SARS-CoV-2 macromolecules and host proteins.

Li G, Tang Z, Fan W, Wang X, Huang L, Jia Y, Wang M, Hu Z, Zhou Y
Cell insight 2023 Feb;2(1):100068

---

Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS.

Wang L, Li S, Wang K, Wang N, Liu Q, Sun Z, Wang L, Wang L, Liu Q, Song C, Yang Q
Immunity 2023 Feb 14;56(2):272-288.e7

---

Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.

Lu D, Liu Y, Huang H, Hu M, Li T, Wang S, Shen S, Wu R, Cai W, Lu T, Lu Z
Translational stroke research 2023 Dec;14(6):910-928

---

Screening Linear and Circular RNA Transcripts from Stress Granules.

Chen S, Zhang J, Zhao F
Genomics, proteomics & bioinformatics 2023 Aug;21(4):886-893

---

TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.

Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P
iScience 2023 Apr 21;26(4):106543

---

Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy.

Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN
Science translational medicine 2022 Nov 23;14(672):eade1633

---

Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.

Prtenjaca N, Rob M, Alam MS, Markovinovic A, Stuani C, Buratti E, Munitic I
International journal of molecular sciences 2022 Jun 19;23(12)

---

FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis.

He Z, Yang J, Sui C, Zhang P, Wang T, Mou T, Sun K, Wang Y, Xu Z, Li G, Deng H, Shi J, Zhuang B
Archives of biochemistry and biophysics 2022 Jun 15;722:109216

---

Integrated stress response restricts macrophage necroptosis.

Place DE, Samir P, Malireddi RS, Kanneganti TD
Life science alliance 2022 Jan;5(1)

---

Key Modulators of the Stress Granule Response TIA1, TDP-43, and G3BP1 Are Altered by Polyglutamine-Expanded ATXN7.

Niss F, Piñero-Paez L, Zaidi W, Hallberg E, Ström AL
Molecular neurobiology 2022 Aug;59(8):5236-5251

---

Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.

Dai B, Zhong T, Chen ZX, Chen W, Zhang N, Liu XL, Wang LQ, Chen J, Liang Y
The Journal of biological chemistry 2021 Oct;297(4):101222

---

Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.

Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591

---

Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.

Zhang M, Yang C, Zhu M, Qian L, Luo Y, Cheng H, Geng R, Xu X, Qian C, Liu Y
Diabetologia 2021 May;64(5):1144-1157

---

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.

Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD
Nature structural & molecular biology 2021 Feb;28(2):132-142

---

Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.

Liu S, Chen L, Chen H, Xu K, Peng X, Zhang M
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66

---

K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.

Yu Y, Zheng Q, Erramilli SK, Pan M, Park S, Xie Y, Li J, Fei J, Kossiakoff AA, Liu L, Zhao M
Nature chemical biology 2021 Aug;17(8):896-905

---

Microvesicles in active lupus nephritis show Toll-like receptor 9-dependent co-expression of galectin-3 binding protein and double-stranded DNA.

Rasmussen NS, Nielsen CT, Nielsen CH, Jacobsen S
Clinical and experimental immunology 2021 Apr;204(1):64-77

---

Porcine Circovirus Type 3 Cap Inhibits Type I Interferon Induction Through Interaction With G3BP1.

Zhang P, Shen H, Liu X, Wang S, Liu Y, Xu Z, Song C
Frontiers in veterinary science 2020;7:594438

---

HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.

Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78

---

The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.

Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, Peng B, He X, Liu W
Journal of virology 2020 Mar 17;94(7)

---

Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.

Cheng J, Gao S, Zhu C, Liu S, Li J, Kang J, Wang Z, Wang T
Journal of virology 2020 Mar 17;94(7)

---

Galactosaminogalactan activates the inflammasome to provide host protection.

Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD
Nature 2020 Dec;588(7839):688-692

---

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.

Patmore DM, Jassim A, Nathan E, Gilbertson RJ, Tahan D, Hoffmann N, Tong Y, Smith KS, Kanneganti TD, Suzuki H, Taylor MD, Northcott P, Gilbertson RJ
Developmental cell 2020 Aug 24;54(4):455-470.e5

---

Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner.

Rasmussen NS, Nielsen CT, Jacobsen S, Nielsen CH
Frontiers in immunology 2019;10:2391

---

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD
Nature 2019 Sep;573(7775):590-594

---

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.

Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB
Nature communications 2019 Dec 6;10(1):5583