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- Antibody Data
- Antigen structure
- References [88]
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- Product number
- 66486-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- G3BP1 antibody
- Antibody type
- Monoclonal
- Description
- G3BP1 antibody (Cat. #66486-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat, pig and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1E4A2
- Vial size
- 20ul, 150ul
Submitted references Microglial TIA1-mediated stress granules promote neuroinflammation and aggravate neuron loss in mice after ischemic stroke by inhibiting IGF2 signaling.
Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m(6)A-IGF2BP1 for Ischemic Stroke Rescue.
Response of Oral and Skin Keratinocytes to Oxidative Stress.
Exploration of Novel Markers in Tan Sheep Spermatogenesis.
Human RBM3 protein is prone to form neuronal aggregates opposed by the proteasome.
TIA1 Mutant Mouse Model Exhibits Motor Deficits and Neurodegenerative Characteristics of Amyotrophic Lateral Sclerosis.
Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.
FUS is an N1- and N6-methyladenosine-binding protein.
RUVBL2 Regulates Microglia Metabolic Reprogramming to Mediate Stress Granules Aggregation Exacerbating Postoperative Delirium in Aged Mild Cognitive Impairment Rats.
Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression.
The neuroprotective effect of Cucurbitacin B against Aβ and tau toxicities requires functional HDAC6 and stress granule pathways.
Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling.
mRNA caps accumulate in stress granules and are essential for their formation.
Loss of age-associated increase in m(6)A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease.
Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity.
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1.
Nonredundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus.
Discovery and Mechanism of 16-19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells.
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection.
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology.
Engineering bi-directional chemically-modulated synthetic condensates for cellular control.
Stress granule component TIA-1 is a negative regulator of the non-canonical NLRP3 inflammasome.
Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice.
G3BP1 Regulates the Cell Cycle by Promoting IFNβ Production to Promote PCV2 Replication and Promotes Nuclear Transfer of Viral Proteins by Direct Binding.
Emerging of Ultrafine Membraneless Organelles as the Missing Piece of Nanostress: Mechanism of Biogenesis and Implications at Multilevels.
Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy.
TIA1-mediated stress granules promote neurodegeneration by sequestering HSP70 mRNA in C9orf72 mice.
µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.
Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance.
Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids.
Transcriptomic and proteomic profiling of bi-partite and tri-partite murine iPSC-derived neurospheroids under steady-state and inflammatory condition.
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties.
TRIM25 predominately associates with anti-viral stress granules.
The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells.
Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke.
HuR-positive stress granules: Potential targets for age-related osteoporosis.
A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis.
The Role of Heat-Induced Stress Granules in the Blood-Testis Barrier of Mice.
The mRNA-capping enzyme localizes to stress granules in the cytoplasm and maintains cap homeostasis of target mRNAs.
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice.
High-throughput and proteome-wide discovery of endogenous biomolecular condensates.
Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer.
DHX38 enhances proliferation, metastasis, and EMT progression in NSCLC through the G3BP1-mediated MAPK pathway.
Lin28a forms an RNA-binding complex with Igf2bp3 to regulate m(6)A-modified stress response genes in stress granules of muscle stem cells.
Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis.
Host RNA N(6)-methyladenosine and incoming DNA N(6)-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance.
Dynamic Localization of Paraspeckle Components under Osmotic Stress.
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.
Mitosis exit followed by death in interphase prevents the development of polyploid giant cancer cells.
Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Stress granules plug and stabilize damaged endolysosomal membranes.
m(1)A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration.
LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
Oleic Acid Dissolves cGAS-DNA Phase Separation to Inhibit Immune Surveillance.
Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.
Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.
The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation.
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1.
Atlas of interactions between SARS-CoV-2 macromolecules and host proteins.
Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS.
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Screening Linear and Circular RNA Transcripts from Stress Granules.
TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy.
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.
FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis.
Integrated stress response restricts macrophage necroptosis.
Key Modulators of the Stress Granule Response TIA1, TDP-43, and G3BP1 Are Altered by Polyglutamine-Expanded ATXN7.
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Microvesicles in active lupus nephritis show Toll-like receptor 9-dependent co-expression of galectin-3 binding protein and double-stranded DNA.
Porcine Circovirus Type 3 Cap Inhibits Type I Interferon Induction Through Interaction With G3BP1.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
Galactosaminogalactan activates the inflammasome to provide host protection.
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner.
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Qian Y, Yu H, Dong J, Liu J, Han J, Zheng T, Zhang W, Wang L, Huang Z, Wang Y
Theranostics 2026;16(5):2627-2648
Theranostics 2026;16(5):2627-2648
Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m(6)A-IGF2BP1 for Ischemic Stroke Rescue.
Li L, Guo YD, Zhang XW, Du ZY, Wang YQ, Yang Z, Luo QW, Zhuo FF, Wei TT, Liu ZP, Han B, Yu W, Zhang PP, Zhou W, Lu ZY, Tu PF, Zheng CH, Zeng KW
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(6):e14703
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(6):e14703
Response of Oral and Skin Keratinocytes to Oxidative Stress.
Zhang Y, Han C, Yuan H, DiPietro LA, Chen L
Cells 2026 Jan 6;15(2)
Cells 2026 Jan 6;15(2)
Exploration of Novel Markers in Tan Sheep Spermatogenesis.
Ma Y, Jin H, Wang N, Xie Y, Zhang L, Cai B
Animals : an open access journal from MDPI 2026 Jan 22;16(2)
Animals : an open access journal from MDPI 2026 Jan 22;16(2)
Human RBM3 protein is prone to form neuronal aggregates opposed by the proteasome.
Kumar S, Kleven T, Ciosk R
Biology open 2026 Jan 1;15(1)
Biology open 2026 Jan 1;15(1)
TIA1 Mutant Mouse Model Exhibits Motor Deficits and Neurodegenerative Characteristics of Amyotrophic Lateral Sclerosis.
Mao LH, Song YN, Zhang JQ, Shao YT, Wang ZL, Yang N, Zhang WX, Zhang YR, Gao XY, Li JY, Yuan L
Cells 2026 Feb 27;15(5)
Cells 2026 Feb 27;15(5)
Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.
Dziagwa C, Seca C, Capron C, Maurizy C, An N, Heusdens D, Budden T, Martin-Morales L, Susaeta Ruiz M, Renaude E, El-Hachem N, Vanleyssem R, Leclercq M, Blomme A, Chariot A, Utikal J, Viros A, Rapino F, Delaunay S, Close P
Nature communications 2026 Feb 25;17(1)
Nature communications 2026 Feb 25;17(1)
FUS is an N1- and N6-methyladenosine-binding protein.
Liang X, Zhao T, Dai X, Sun Y, Yuan J, Afzalpurkar S, Duong C, Yu A, Tang F, He X, Liu X, Chen X, Cao Z, Wang Y
Nucleic acids research 2026 Feb 24;54(5)
Nucleic acids research 2026 Feb 24;54(5)
RUVBL2 Regulates Microglia Metabolic Reprogramming to Mediate Stress Granules Aggregation Exacerbating Postoperative Delirium in Aged Mild Cognitive Impairment Rats.
Zhang L, Wang Z, Yang C, Wang X, Liu X, Zhang H, Liu H, Liao H, Chen J, Wang H
Aging cell 2026 Apr;25(4):e70458
Aging cell 2026 Apr;25(4):e70458
Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression.
Yue T, Yin H, Yuan L, Xie X, Xie H, Gong M, Xu X, Sun C, Zhang K, Liu J
Oncogene 2026 Apr 24;
Oncogene 2026 Apr 24;
The neuroprotective effect of Cucurbitacin B against Aβ and tau toxicities requires functional HDAC6 and stress granule pathways.
Tu X, Fang M, Yan Y, Liu Y, Yu J, Chen L, Zhang L, Huang C, Fan S
Biogerontology 2026 Apr 21;27(3)
Biogerontology 2026 Apr 21;27(3)
Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling.
Zheng LT, Yan ZS, Li XY, Chang JJ, Tan XQ, Wang YX, Ding HM, Liu Q, Ma YQ, Huo D
Nature communications 2025 Oct 29;16(1):9554
Nature communications 2025 Oct 29;16(1):9554
mRNA caps accumulate in stress granules and are essential for their formation.
Guo M, Feng Y, Qi G, Ma W, He X, Li R, Liu Y, Wang J
Cellular and molecular life sciences : CMLS 2025 Nov 25;82(1):420
Cellular and molecular life sciences : CMLS 2025 Nov 25;82(1):420
Loss of age-associated increase in m(6)A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease.
Libera JL, Hu J, Nguyen TA, Wang Z, van der Spek SJF, Schult K, Dorrian L, Majka J, Tobunluepop K, Puri S, Kynshov A, Kanaan NM, Nelson PT, Meyer K, Hou L, Zhang X, Wolozin B
bioRxiv : the preprint server for biology 2025 May 7;
bioRxiv : the preprint server for biology 2025 May 7;
Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity.
Barbieri EM, Linsenmeier M, Whiteman KR, Cheng Y, Braganza S, Copley KE, Miranda-Castrodad P, Lewis B, Villafañe K, Amado DA, Davidson BL, Shorter J
bioRxiv : the preprint server for biology 2025 May 10;
bioRxiv : the preprint server for biology 2025 May 10;
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1.
Li Y, Fang J, Ding Y, Zhang X, Liu Y, Qiu W, Xu H, Kang Y, Chen J, Gao Y, Zhao YG, Yang P, Wang B, Tian W, Chen Y, Bi W, Zhang P
Nature communications 2025 Jun 5;16(1):5227
Nature communications 2025 Jun 5;16(1):5227
Nonredundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus.
Dalla Rosa I, Kent L, Way M
Nucleic acids research 2025 Jun 20;53(12)
Nucleic acids research 2025 Jun 20;53(12)
Discovery and Mechanism of 16-19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells.
Shen Z, Yang X, Seabra G, Xu X, Dong J, Brant JO, Zhou W, Guan J, Jiang W, Li C
ACS chemical biology 2025 Jun 20;20(6):1333-1346
ACS chemical biology 2025 Jun 20;20(6):1333-1346
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
Meng F, Li H, Huang Y, Wang C, Liu Y, Zhang C, Chen D, Zeng T, Zhang S, Li Y, Zhang B, Lang C, Xia J, Xiong W, Pan S, Sun X, Thorne RF, Liu Y, Wang J, Zhang S, Song R, Wang J, Liu L
Nature cancer 2025 Jul;6(7):1223-1241
Nature cancer 2025 Jul;6(7):1223-1241
The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection.
Lavender AA, Solanke O, Tang H-Y, Peck HE, Vanover D, Santangelo PJ, Brinton MA
Journal of virology 2025 Jul 22;99(7):e0079425
Journal of virology 2025 Jul 22;99(7):e0079425
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology.
Mohan HM, Fernandez MG, Huang C, Lin R, Ryou JH, Seyfried D, Grotewold N, Barget AJ, Whiteley AM, Basrur V, Mosalaganti S, Paulson HL, Sharkey LM
Science advances 2025 Jul 18;11(29):eadu6354
Science advances 2025 Jul 18;11(29):eadu6354
Engineering bi-directional chemically-modulated synthetic condensates for cellular control.
Zhen N, Yan Y, Zhu G, Zhu T, Zhang Q, Chen Q, Guo Y, Zhu J, Pan Q, Xie J
Nature communications 2025 Jul 17;16(1):6587
Nature communications 2025 Jul 17;16(1):6587
Stress granule component TIA-1 is a negative regulator of the non-canonical NLRP3 inflammasome.
Lamichhane PP, Aditi, Neil BH, Kilgore PB, Torres AG, Chopra AK, Samir P
bioRxiv : the preprint server for biology 2025 Jul 16;
bioRxiv : the preprint server for biology 2025 Jul 16;
Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice.
Zhou Y, Yang Z, Wang Y, Dong Y, Wang T, Li Y, Liang C, Liu Y, Li Z, Liu S, Gui L, Fan Y, Lei T, Jia K, Zhang L, Wang M, Nie W, Chen L, Ma M, Wu Y, Zhong C, Liu H, Hou J
Nature communications 2025 Jul 1;16(1):5610
Nature communications 2025 Jul 1;16(1):5610
G3BP1 Regulates the Cell Cycle by Promoting IFNβ Production to Promote PCV2 Replication and Promotes Nuclear Transfer of Viral Proteins by Direct Binding.
Zhang X, Li K, Zhou S, Zhang L, Wang L, Liu Y, Wang S, Xu G, Liang P, Xu Z, Song C
International journal of molecular sciences 2025 Jan 27;26(3)
International journal of molecular sciences 2025 Jan 27;26(3)
Emerging of Ultrafine Membraneless Organelles as the Missing Piece of Nanostress: Mechanism of Biogenesis and Implications at Multilevels.
Liu J, Zheng L, Li X, Tang W, Guo M, Wang Y, Tan X, Chang J, Zhao H, Zhu D, Ma YQ, Huo D
ACS nano 2025 Feb 11;19(5):5659-5679
ACS nano 2025 Feb 11;19(5):5659-5679
Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy.
Zhang H, Zhang Y, Chen Y, Zhong W, Tan S, Wang J, Yan H, Yan N, Lin M, Liu X, Chang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e09781
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e09781
TIA1-mediated stress granules promote neurodegeneration by sequestering HSP70 mRNA in C9orf72 mice.
Wei Y, Li D, Yang R, Liu Y, Luo X, Zhao W, Yang H, Chen Z, Shen C, Wang Y, Huang Z
Brain : a journal of neurology 2025 Dec 4;148(12):4482-4494
Brain : a journal of neurology 2025 Dec 4;148(12):4482-4494
µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.
Pan CR, Knutson SD, Huth SW, MacMillan DWC
Nature chemical biology 2025 Apr;21(4):490-500
Nature chemical biology 2025 Apr;21(4):490-500
Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance.
Peng Y, Yin H, Pei X, Zhang Y, Wang C, Zheng X, Liang H, Yang H, Li S
Acta neuropathologica communications 2025 Apr 25;13(1):84
Acta neuropathologica communications 2025 Apr 25;13(1):84
Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids.
Govaerts J, Van Breedam E, De Beuckeleer S, Goethals C, D'Incal CP, Di Stefano J, Van Calster S, Buyle-Huybrecht T, Boeren M, De Reu H, Paludan SR, Thiry M, Lebrun M, Sadzot-Delvaux C, Motaln H, Rogelj B, Van Weyenbergh J, De Vos WH, Vanden Berghe W, Ogunjimi B, Delputte P, Ponsaerts P
Frontiers in immunology 2024;15:1458967
Frontiers in immunology 2024;15:1458967
Transcriptomic and proteomic profiling of bi-partite and tri-partite murine iPSC-derived neurospheroids under steady-state and inflammatory condition.
Di Stefano J, Garcia-Pupo L, Di Marco F, Motaln H, Govaerts J, Van Breedam E, Mateiu LM, Van Calster S, Ricciardi L, Quarta A, Verstraelen P, De Vos WH, Rogelj B, Cicalini I, De Laurenzi V, Del Boccio P, FitzGerald U, Vanden Berghe W, Verhoye M, Pieragostino D, Ponsaerts P
Brain, behavior, and immunity 2024 Oct;121:1-12
Brain, behavior, and immunity 2024 Oct;121:1-12
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties.
Mohan HM, Fernandez MG, Huang C, Lin R, Ryou JH, Seyfried D, Grotewold N, Whiteley AM, Barmada SJ, Basrur V, Mosalaganti S, Paulson HL, Sharkey LM
bioRxiv : the preprint server for biology 2024 Oct 25;
bioRxiv : the preprint server for biology 2024 Oct 25;
TRIM25 predominately associates with anti-viral stress granules.
Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau DD, Yang P, Zhang L, Zhou F, Bai P, Jia D
Nature communications 2024 May 15;15(1):4127
Nature communications 2024 May 15;15(1):4127
The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells.
Vicente JJ, Khan K, Tillinghast G, McFaline-Figueroa JL, Sancak Y, Stella N
Journal of translational medicine 2024 May 10;22(1):441
Journal of translational medicine 2024 May 10;22(1):441
Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke.
Sun B, Luo J, Li Z, Chen D, Wang Q, Si W
Experimental neurology 2024 Mar;373:114678
Experimental neurology 2024 Mar;373:114678
HuR-positive stress granules: Potential targets for age-related osteoporosis.
Huai Y, Wang X, Mao W, Wang X, Zhao Y, Chu X, Huang Q, Ru K, Zhang L, Li Y, Chen Z, Qian A
Aging cell 2024 Mar;23(3):e14053
Aging cell 2024 Mar;23(3):e14053
A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis.
Liu Q, Wang F, Chen Y, Cui H, Wu H
Journal of hazardous materials 2024 Mar 5;465:133038
Journal of hazardous materials 2024 Mar 5;465:133038
The Role of Heat-Induced Stress Granules in the Blood-Testis Barrier of Mice.
Zhao Z, Cai Y, Lin X, Liu N, Qin Y, Wu Y
International journal of molecular sciences 2024 Mar 25;25(7)
International journal of molecular sciences 2024 Mar 25;25(7)
The mRNA-capping enzyme localizes to stress granules in the cytoplasm and maintains cap homeostasis of target mRNAs.
Gayen A, Mukherjee A, Kumar K, Majumder S, Chakrabarti S, Mukherjee C
Journal of cell science 2024 Jun 1;137(11)
Journal of cell science 2024 Jun 1;137(11)
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice.
Wu Y, Zhang H, Wang Y, Zhang Y, Hong Z, Wang D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116869
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116869
High-throughput and proteome-wide discovery of endogenous biomolecular condensates.
Li P, Chen P, Qi F, Shi J, Zhu W, Li J, Zhang P, Xie H, Li L, Lei M, Ren X, Wang W, Zhang L, Xiang X, Zhang Y, Gao Z, Feng X, Du W, Liu X, Xia L, Liu BF, Li Y
Nature chemistry 2024 Jul;16(7):1101-1112
Nature chemistry 2024 Jul;16(7):1101-1112
Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer.
Li Y, Xu C, Qian X, Wang G, Han C, Hua H, Dong M, Chen J, Yu H, Zhang R, Feng X, Yang Z, Pan Y
Cell death discovery 2024 Jul 30;10(1):344
Cell death discovery 2024 Jul 30;10(1):344
DHX38 enhances proliferation, metastasis, and EMT progression in NSCLC through the G3BP1-mediated MAPK pathway.
Mi K, Zeng L, Chen Y, Ning J, Zhang S, Zhao P, Yang S
Cellular signalling 2024 Jan;113:110962
Cellular signalling 2024 Jan;113:110962
Lin28a forms an RNA-binding complex with Igf2bp3 to regulate m(6)A-modified stress response genes in stress granules of muscle stem cells.
Song D, Chen Y, Wang P, Cheng Y, Shyh-Chang N
Cell proliferation 2024 Dec;57(12):e13707
Cell proliferation 2024 Dec;57(12):e13707
Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis.
Li Z, Luo L, Ju X, Huang S, Lei L, Yu Y, Liu J, Zhang P, Chi T, Ma P, Huang C, Huang X, Ding Q, Zhang Y
The EMBO journal 2024 Dec;43(24):6444-6468
The EMBO journal 2024 Dec;43(24):6444-6468
Host RNA N(6)-methyladenosine and incoming DNA N(6)-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance.
Wang N, Liu Q, Wang B, Yang Z, Li S, Li R, Liang X, Fan J, Wang H, Sun Z, Dong L, Hou Y, Wang S, Song C, Wang Y, Quan C, Yang Q, Wang L
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4418-4434
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4418-4434
Dynamic Localization of Paraspeckle Components under Osmotic Stress.
Yucel-Polat A, Campos-Melo D, Alikhah A, Strong MJ
Non-coding RNA 2024 Apr 12;10(2)
Non-coding RNA 2024 Apr 12;10(2)
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.
Wang F, Wang L, Gan S, Feng S, Ouyang S, Wang X, Yuan S
Research (Washington, D.C.) 2023;6:0091
Research (Washington, D.C.) 2023;6:0091
Mitosis exit followed by death in interphase prevents the development of polyploid giant cancer cells.
Vicente JJ, Khan K, Tillinghast G, McFaline-Figueroa JL, Sancak Y, Stella N
bioRxiv : the preprint server for biology 2023 Oct 5;
bioRxiv : the preprint server for biology 2023 Oct 5;
Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways.
Webber CJ, Murphy CN, Rondón-Ortiz AN, van der Spek SJF, Kelly EX, Lampl NM, Chiesa G, Khalil AS, Emili A, Wolozin B
Human molecular genetics 2023 Oct 4;32(20):2966-2980
Human molecular genetics 2023 Oct 4;32(20):2966-2980
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Stress granules plug and stabilize damaged endolysosomal membranes.
Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG
Nature 2023 Nov;623(7989):1062-1069
Nature 2023 Nov;623(7989):1062-1069
m(1)A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration.
Sun Y, Dai H, Dai X, Yin J, Cui Y, Liu X, Gonzalez G, Yuan J, Tang F, Wang N, Perlegos AE, Bonini NM, Yang XW, Gu W, Wang Y
Nature 2023 Nov;623(7987):580-587
Nature 2023 Nov;623(7987):580-587
LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
Chen L, Sun K, Qin W, Huang B, Wu C, Chen J, Lai Q, Wang X, Zhou R, Li A, Liu S, Zhang Y
Cancer letters 2023 Nov 1;576:216420
Cancer letters 2023 Nov 1;576:216420
Oleic Acid Dissolves cGAS-DNA Phase Separation to Inhibit Immune Surveillance.
Wang L, Liu Q, Wang N, Li S, Bian W, Sun Z, Wang L, Wang L, Liu C, Song C, Liu Q, Yang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2206820
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2206820
Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.
Wu X, Yang ZH, Wu J, Han J
Immunity 2023 May 9;56(5):926-943.e7
Immunity 2023 May 9;56(5):926-943.e7
Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.
Shi WP, Lin WJ, Ge WY, Chen LL, Zhang TD, Guo WH, Liu JL, Yin DC
Food & function 2023 May 22;14(10):4621-4631
Food & function 2023 May 22;14(10):4621-4631
The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation.
Feng Z, Mao Z, Yang Z, Liu X, Nakamura F
Journal of cell science 2023 Mar 15;136(6)
Journal of cell science 2023 Mar 15;136(6)
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.
Szczerba M, Johnson B, Acciai F, Gogerty C, McCaughan M, Williams J, Kibler KV, Jacobs BL
Science signaling 2023 Mar 14;16(776):eabq0837
Science signaling 2023 Mar 14;16(776):eabq0837
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y
Autophagy 2023 Jul;19(7):1934-1951
Autophagy 2023 Jul;19(7):1934-1951
T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1.
Jiang T, Qi X, Lin R, Jiang J, Wen J, Deng Y
Ecotoxicology and environmental safety 2023 Jul 1;259:115028
Ecotoxicology and environmental safety 2023 Jul 1;259:115028
Atlas of interactions between SARS-CoV-2 macromolecules and host proteins.
Li G, Tang Z, Fan W, Wang X, Huang L, Jia Y, Wang M, Hu Z, Zhou Y
Cell insight 2023 Feb;2(1):100068
Cell insight 2023 Feb;2(1):100068
Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS.
Wang L, Li S, Wang K, Wang N, Liu Q, Sun Z, Wang L, Wang L, Liu Q, Song C, Yang Q
Immunity 2023 Feb 14;56(2):272-288.e7
Immunity 2023 Feb 14;56(2):272-288.e7
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Lu D, Liu Y, Huang H, Hu M, Li T, Wang S, Shen S, Wu R, Cai W, Lu T, Lu Z
Translational stroke research 2023 Dec;14(6):910-928
Translational stroke research 2023 Dec;14(6):910-928
Screening Linear and Circular RNA Transcripts from Stress Granules.
Chen S, Zhang J, Zhao F
Genomics, proteomics & bioinformatics 2023 Aug;21(4):886-893
Genomics, proteomics & bioinformatics 2023 Aug;21(4):886-893
TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.
Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P
iScience 2023 Apr 21;26(4):106543
iScience 2023 Apr 21;26(4):106543
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy.
Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN
Science translational medicine 2022 Nov 23;14(672):eade1633
Science translational medicine 2022 Nov 23;14(672):eade1633
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.
Prtenjaca N, Rob M, Alam MS, Markovinovic A, Stuani C, Buratti E, Munitic I
International journal of molecular sciences 2022 Jun 19;23(12)
International journal of molecular sciences 2022 Jun 19;23(12)
FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis.
He Z, Yang J, Sui C, Zhang P, Wang T, Mou T, Sun K, Wang Y, Xu Z, Li G, Deng H, Shi J, Zhuang B
Archives of biochemistry and biophysics 2022 Jun 15;722:109216
Archives of biochemistry and biophysics 2022 Jun 15;722:109216
Integrated stress response restricts macrophage necroptosis.
Place DE, Samir P, Malireddi RS, Kanneganti TD
Life science alliance 2022 Jan;5(1)
Life science alliance 2022 Jan;5(1)
Key Modulators of the Stress Granule Response TIA1, TDP-43, and G3BP1 Are Altered by Polyglutamine-Expanded ATXN7.
Niss F, Piñero-Paez L, Zaidi W, Hallberg E, Ström AL
Molecular neurobiology 2022 Aug;59(8):5236-5251
Molecular neurobiology 2022 Aug;59(8):5236-5251
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
Dai B, Zhong T, Chen ZX, Chen W, Zhang N, Liu XL, Wang LQ, Chen J, Liang Y
The Journal of biological chemistry 2021 Oct;297(4):101222
The Journal of biological chemistry 2021 Oct;297(4):101222
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.
Zhang M, Yang C, Zhu M, Qian L, Luo Y, Cheng H, Geng R, Xu X, Qian C, Liu Y
Diabetologia 2021 May;64(5):1144-1157
Diabetologia 2021 May;64(5):1144-1157
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD
Nature structural & molecular biology 2021 Feb;28(2):132-142
Nature structural & molecular biology 2021 Feb;28(2):132-142
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Liu S, Chen L, Chen H, Xu K, Peng X, Zhang M
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Yu Y, Zheng Q, Erramilli SK, Pan M, Park S, Xie Y, Li J, Fei J, Kossiakoff AA, Liu L, Zhao M
Nature chemical biology 2021 Aug;17(8):896-905
Nature chemical biology 2021 Aug;17(8):896-905
Microvesicles in active lupus nephritis show Toll-like receptor 9-dependent co-expression of galectin-3 binding protein and double-stranded DNA.
Rasmussen NS, Nielsen CT, Nielsen CH, Jacobsen S
Clinical and experimental immunology 2021 Apr;204(1):64-77
Clinical and experimental immunology 2021 Apr;204(1):64-77
Porcine Circovirus Type 3 Cap Inhibits Type I Interferon Induction Through Interaction With G3BP1.
Zhang P, Shen H, Liu X, Wang S, Liu Y, Xu Z, Song C
Frontiers in veterinary science 2020;7:594438
Frontiers in veterinary science 2020;7:594438
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78
Frontiers in microbiology 2020;11:78
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, Peng B, He X, Liu W
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
Cheng J, Gao S, Zhu C, Liu S, Li J, Kang J, Wang Z, Wang T
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
Galactosaminogalactan activates the inflammasome to provide host protection.
Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD
Nature 2020 Dec;588(7839):688-692
Nature 2020 Dec;588(7839):688-692
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Patmore DM, Jassim A, Nathan E, Gilbertson RJ, Tahan D, Hoffmann N, Tong Y, Smith KS, Kanneganti TD, Suzuki H, Taylor MD, Northcott P, Gilbertson RJ
Developmental cell 2020 Aug 24;54(4):455-470.e5
Developmental cell 2020 Aug 24;54(4):455-470.e5
Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner.
Rasmussen NS, Nielsen CT, Jacobsen S, Nielsen CH
Frontiers in immunology 2019;10:2391
Frontiers in immunology 2019;10:2391
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD
Nature 2019 Sep;573(7775):590-594
Nature 2019 Sep;573(7775):590-594
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB
Nature communications 2019 Dec 6;10(1):5583
Nature communications 2019 Dec 6;10(1):5583
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