Explore
Validate
Learn21574-1-AP
antibody from Proteintech Group
Targeting: TNFRSF1A
CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [91]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 21574-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21574-1-AP, RRID:AB_10734433
- Product name
- TNFR1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TNFR1 antibody (Cat. #21574-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A pH/ROS dual-responsive metal-polyphenol-antibiotic nano-assembly for combating persistent infection by overcoming biofilm and cell membrane barriers.
RIPK1-driven calcium overload and lysosomal-mitochondrial dysfunction induce testicular necroptosis following DEHP exposure.
Genipin rewires endogenous amino acid metabolism and induces hepatocellular necroptosis by activation of the TNF-necrosome signaling axis.
A SASP-related four-gene signature associated with intervertebral disc degeneration: integrated bioinformatics analysis and validation of pinocembrin as a therapeutic candidate.
Targeting GALNT4 suppresses atherosclerosis via TNFR1/NF-κB mediated attenuation of endothelial inflammation.
Zhigancao decoction alleviates Parkinson's disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosis.
Inhibition of SCD1 attenuates neuroinflammation and brain injury after cerebral ischemia-reperfusion.
Celastrol disrupts the inflammatory feedback loop driven by Tenascin-C⁺ fibroblast subtype in psoriasis: Insights from single-cell RNA sequencing and experimental validation.
Deciphering the Therapeutic Mechanisms of Banxia Xiexin Decoction Against Ulcerative Colitis: Targeting Pyroptosis and Necroptosis.
Identification of biomarkers for the diagnosis of type 2 diabetes mellitus with metabolic associated fatty liver disease by bioinformatics analysis and experimental validation.
IgG promotes TNF-α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF-κB signalling pathway.
Aqueous extract of Solanum americanum Mill. relieves functional constipation by modulating the enteric nervous system and gut micro-ecosystems.
Salvianolic Acid B Inhibits ZBP1-Mediated PANoptosis in Mycobacterium tuberculosis-Infected Macrophages by Targeting TNFR1.
MK3 Gene Upregulates Granulosa Cell Apoptosis Through the TNF/P38 MAPK Pathway in Chicken.
Immunohistochemical Expression of TNFR1, IL-6, and TGF-β1 in the Synovial Tissue of Patients with Hip Osteoarthritis.
Pyroptosis was suppressed by 20-hydroxyecdysone through Lin28b-mediated let-7d in vascular endothelial cells.
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells.
Targeting inflammation and necroptosis in diabetic kidney disease: A novel approach via PPARα modulation.
TNF-α inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway.
Cadmium exposure induces Leydig cell injury via necroptosis caused by oxidative stress and TNF-α/TNFR1 signaling.
MEIS1-mediated Apoptosis via TNFR1 in Endometriosis.
Macrophage membrane functionalized composite microspheres promote bone regeneration in periodontitis via manipulating inflammation reversing-osteogenesis coupling.
An approach for psoriasis of microneedle patch simultaneously targeting multiple inflammatory cytokines and relapse related T cells.
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
Astaxanthin prevents postovulatory oocyte aging by targeting TNFR2 and inhibiting the TNF signaling pathway.
Tumor Necrosis Factor Receptor 1 Is Required for Human Umbilical Cord-Derived Mesenchymal Stem Cell-Mediated Rheumatoid Arthritis Therapy.
Classical prescription Daqinjiao decoction inhibit cerebral ischemia/reperfusion induced necroptosis and ferroptosis through multiple mechanisms.
Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury.
Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.
Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes.
Supplemented Gegen Qinlian Decoction Formula attenuates podocyte mitochondrial fission and renal fibrosis in diabetic kidney disease by inhibiting TNF-α-mediated necroptosis, compared with empagliflozin.
Tetramethylpyrazine inhibits the inflammatory response by downregulating the TNFR1/IκB-α/NF-κB p65 pathway after spinal cord injury.
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
The roles of gut microbiome and metabolites associated with skin photoaging in mice by intestinal flora sequencing and metabolomics.
Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.
Porphyromonas gingivalis Lipopolysaccharide Damages Mucosal Barrier to Promote Gastritis-Associated Carcinogenesis.
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.
Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment.
Hyaluronic Acid-Based Reactive Oxygen Species-Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing.
EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.
Huangqi Jiuni decoction prevents acute kidney injury induced by severe burns by inhibiting activation of the TNF/NF-κB pathway.
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling.
Ursolic Acid Promotes Autophagy by Inhibiting Akt/mTOR and TNF-α/TNFR1 Signaling Pathways to Alleviate Pyroptosis and Necroptosis in Mycobacterium tuberculosis-Infected Macrophages.
Exogenous IL-10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis-induced macrophage polarization.
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma.
Integrated analysis of potential biomarkers associated with diabetic periodontitis development based on bioinformatics: An observational study.
Repurposing crizotinib to target RIPK1-dependent cell death.
Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis.
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line.
TNFα/TNFR1 signal induces excessive senescence of decidua stromal cells in recurrent pregnancy loss.
Repositioning linifanib as a potent anti-necroptosis agent for sepsis.
Plasma soluble tumor necrosis factor receptor I as a biomarker of lupus nephritis and disease activity in systemic lupus erythematosus patients.
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling.
Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.
Finerenone attenuates myocardial apoptosis, metabolic disturbance and myocardial fibrosis in type 2 diabetes mellitus.
Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis.
Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: A network pharmacology study and in vivo experimental validation.
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.
Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer.
MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis.
Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
The Impact of β-1,4-Galactosyltransferase V on Microglial Function.
Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension.
Effect of pyrroloquinoline quinone on lipopolysaccharide-induced autophagy in HAPI microglia cells.
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.
A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
Orientia tsutsugamushi modulates cellular levels of NF-κB inhibitor p105.
The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota.
Cerebral Immunohistochemical Characterization of the H(2)S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.
KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.
The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.
Lymphotoxins Promote the Progression of Human Lymphatic Malformation by Enhancing Lymphatic Endothelial Cell Proliferation.
TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3.
Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.
Tripartite motif-containing 28 bridges endothelial inflammation and angiogenic activity by retaining expression of TNFR-1 and -2 and VEGFR2 in endothelial cells.
Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells.
Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.
Effect of acute lipopolysaccharide-induced inflammation in intracerebroventricular-streptozotocin injected rats.
Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo.
Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.
TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.
Du J, Zhang Q, Wang Z, Jin Y, Gao F, Kong Y, Bianco A, Ge S, Ma B
Biomaterials 2026 Oct;333:124168
Biomaterials 2026 Oct;333:124168
RIPK1-driven calcium overload and lysosomal-mitochondrial dysfunction induce testicular necroptosis following DEHP exposure.
Ran M, Yi R, Zhang H, Sun X, Qiu T, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G
Ecotoxicology and environmental safety 2026 May;316:120163
Ecotoxicology and environmental safety 2026 May;316:120163
Genipin rewires endogenous amino acid metabolism and induces hepatocellular necroptosis by activation of the TNF-necrosome signaling axis.
Lyu D, Zhang F, Lauschke VM, Qin J, Gao X, Zhang H, Wang L, Wang G, Wei Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):6765-6780
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):6765-6780
A SASP-related four-gene signature associated with intervertebral disc degeneration: integrated bioinformatics analysis and validation of pinocembrin as a therapeutic candidate.
Yao GL, Wang SJ, Zhang Y, Liu JM, Song HH, Liu ZL
Molecular biology reports 2026 Mar 21;53(1)
Molecular biology reports 2026 Mar 21;53(1)
Targeting GALNT4 suppresses atherosclerosis via TNFR1/NF-κB mediated attenuation of endothelial inflammation.
Wei P, Li D, Chen W, Zhang X, Xinru W, Han Z, Wang Y, Guo L
Cellular signalling 2026 Jan;137:112209
Cellular signalling 2026 Jan;137:112209
Zhigancao decoction alleviates Parkinson's disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosis.
Zhang J, Yu X, Fang Y, Li W, Cui Q, Liu X, Jiang Y, Zhang Y, Xu C, Sun X, Lu Y
iScience 2026 Jan 16;29(1):114489
iScience 2026 Jan 16;29(1):114489
Inhibition of SCD1 attenuates neuroinflammation and brain injury after cerebral ischemia-reperfusion.
Li S, Li X Jr, Peng L, Ding H, Shi X, Liu J, Li H, Xu J, Sun Q
Brain research bulletin 2026 Feb;235:111693
Brain research bulletin 2026 Feb;235:111693
Celastrol disrupts the inflammatory feedback loop driven by Tenascin-C⁺ fibroblast subtype in psoriasis: Insights from single-cell RNA sequencing and experimental validation.
Ma Y, Zhang X, Chen X, Zhang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157988
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157988
Deciphering the Therapeutic Mechanisms of Banxia Xiexin Decoction Against Ulcerative Colitis: Targeting Pyroptosis and Necroptosis.
Lu J, Liang K, Zhang L, Cui B, You L, An R, Hu C, Wang X
Journal of inflammation research 2025;18:17537-17560
Journal of inflammation research 2025;18:17537-17560
Identification of biomarkers for the diagnosis of type 2 diabetes mellitus with metabolic associated fatty liver disease by bioinformatics analysis and experimental validation.
Wu G, Wu S, Xiong T, Yao Y, Qiu Y, Meng L, Chen C, Yang X, Liang X, Qin Y
Frontiers in endocrinology 2025;16:1512503
Frontiers in endocrinology 2025;16:1512503
IgG promotes TNF-α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF-κB signalling pathway.
Yin H, Teng Y, Deng GM
Clinical & translational immunology 2025;14(5):e70034
Clinical & translational immunology 2025;14(5):e70034
Aqueous extract of Solanum americanum Mill. relieves functional constipation by modulating the enteric nervous system and gut micro-ecosystems.
Gao X, Li Y, Hu Y, Yang W, Peng L, Sheng J, Tian Y, Yao L, Zhao Y
Frontiers in nutrition 2025;12:1573516
Frontiers in nutrition 2025;12:1573516
Salvianolic Acid B Inhibits ZBP1-Mediated PANoptosis in Mycobacterium tuberculosis-Infected Macrophages by Targeting TNFR1.
Shen J, Fu Y, Liu F, Wu J, Zhang H, Sun J, Miao Z, Jiang X
Phytotherapy research : PTR 2025 Sep;39(9):4028-4045
Phytotherapy research : PTR 2025 Sep;39(9):4028-4045
MK3 Gene Upregulates Granulosa Cell Apoptosis Through the TNF/P38 MAPK Pathway in Chicken.
Chen L, Liu J, Zhang Y, Pi J, Wu Y
Cells 2025 Oct 20;14(20)
Cells 2025 Oct 20;14(20)
Immunohistochemical Expression of TNFR1, IL-6, and TGF-β1 in the Synovial Tissue of Patients with Hip Osteoarthritis.
Todorović P, Jurić I, Kelam N, Rošin M, Čarić D, Boban D, Kopilaš A, Vukojević K
Biomedicines 2025 Nov 7;13(11)
Biomedicines 2025 Nov 7;13(11)
Pyroptosis was suppressed by 20-hydroxyecdysone through Lin28b-mediated let-7d in vascular endothelial cells.
Chen D, Yang J, Ren L, Zheng Z, Jin Z, Wen J, He J, Ding R, Wang J, Lin R, Song Q
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):6083-6097
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):6083-6097
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells.
Mukherjee G, Samanta S, Bishayi B
Microbial pathogenesis 2025 May;202:107416
Microbial pathogenesis 2025 May;202:107416
Targeting inflammation and necroptosis in diabetic kidney disease: A novel approach via PPARα modulation.
Wang Y, Feng X, Li Y, Niu S, Li J, Shi H, Wang G, Wang L
International immunopharmacology 2025 May 8;154:114562
International immunopharmacology 2025 May 8;154:114562
TNF-α inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway.
Zhang Y, Wu Y, Ding B, Li Q, Chen X, Liu H, Xu M, Lan Y, Li Y
Scientific reports 2025 May 12;15(1):16448
Scientific reports 2025 May 12;15(1):16448
Cadmium exposure induces Leydig cell injury via necroptosis caused by oxidative stress and TNF-α/TNFR1 signaling.
Zheng X, Sun Y, Wang J, Yin Y, Li Z, Liu B, Hu H, Xu J, Dai Y, Kanwar YS, Tang Y
Biochemical and biophysical research communications 2025 May 1;761:151717
Biochemical and biophysical research communications 2025 May 1;761:151717
MEIS1-mediated Apoptosis via TNFR1 in Endometriosis.
Wang W, Fu F, Li Y, Li S, Yuan M, Wang T, Ren W, Wei J, Chen D, Wang S, Ma X, Wu Z
Reproductive sciences (Thousand Oaks, Calif.) 2025 Mar;32(3):716-727
Reproductive sciences (Thousand Oaks, Calif.) 2025 Mar;32(3):716-727
Macrophage membrane functionalized composite microspheres promote bone regeneration in periodontitis via manipulating inflammation reversing-osteogenesis coupling.
Song R, Wan Z, Yuan X, Wang N, Gao Y, Zhang L, Ren H, Jin Y, Liu X, Sang J, Yuan Z, Zhao Y
Materials today. Bio 2025 Jun;32:101789
Materials today. Bio 2025 Jun;32:101789
An approach for psoriasis of microneedle patch simultaneously targeting multiple inflammatory cytokines and relapse related T cells.
Huang L, Luo Y, Kuai L, Zhang X, Zhang Y, Yang Z, Fei X, Sun J, Luo Y, Zhao Y, Xue T, Yin W, Chang J, Song J, Li Y, Li B, Li Y
Biomaterials 2025 Jul;318:123120
Biomaterials 2025 Jul;318:123120
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
Bai L, Li N, Li H, Dai Y, Bai Y, Ma F, Sha D, Xia S, Xu Y, Cao X
Journal of nanobiotechnology 2025 Jul 5;23(1):488
Journal of nanobiotechnology 2025 Jul 5;23(1):488
Astaxanthin prevents postovulatory oocyte aging by targeting TNFR2 and inhibiting the TNF signaling pathway.
Wen X, Han Z, Yang Q, Shi KS, Sun D, Zhang XJ, Liang CG
BMC biology 2025 Jul 1;23(1):176
BMC biology 2025 Jul 1;23(1):176
Tumor Necrosis Factor Receptor 1 Is Required for Human Umbilical Cord-Derived Mesenchymal Stem Cell-Mediated Rheumatoid Arthritis Therapy.
Liu G, Wang H, Zhang C, Li X, Mi Y, Chen Y, Xu L, Miao L, Long H, Liu Y
Cell transplantation 2025 Jan-Dec;34:9636897241301703
Cell transplantation 2025 Jan-Dec;34:9636897241301703
Classical prescription Daqinjiao decoction inhibit cerebral ischemia/reperfusion induced necroptosis and ferroptosis through multiple mechanisms.
Liu Y, Liu J, Hu N, Li Z, Liu A, Luo R, Du S, Guo D, Li J, Duan J
Journal of ethnopharmacology 2025 Jan 31;340:119300
Journal of ethnopharmacology 2025 Jan 31;340:119300
Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury.
Wu D, Ma W, Wang L, Long C, Chen S, Liu J, Qian Y, Zhao J, Zhou C, Jia R
Materials today. Bio 2025 Apr;31:101528
Materials today. Bio 2025 Apr;31:101528
Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.
Wang Q, Liu F, Li Y, Zhang H, Qi X, Wu K, Zhang Y, You S, Liu W, Hui X, Li H, Zhu L, Gao H, Cheng J
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4544-4559
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4544-4559
Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes.
Ghosh R, Bishayi B
Cellular immunology 2024 Nov-Dec;405-406:104878
Cellular immunology 2024 Nov-Dec;405-406:104878
Supplemented Gegen Qinlian Decoction Formula attenuates podocyte mitochondrial fission and renal fibrosis in diabetic kidney disease by inhibiting TNF-α-mediated necroptosis, compared with empagliflozin.
Wang Y, Yu L, Li Y, Cha S, Shi L, Wang J, Ge F, Huang C, Huang H, Tu Y, Wan Y, Shen S
Journal of ethnopharmacology 2024 Nov 15;334:118572
Journal of ethnopharmacology 2024 Nov 15;334:118572
Tetramethylpyrazine inhibits the inflammatory response by downregulating the TNFR1/IκB-α/NF-κB p65 pathway after spinal cord injury.
Liu G, Huo L, Deng B, Jiang S, Zhao Y, Mo Y, Bai H, Xu L, Hu C, Mu X
Toxicology and applied pharmacology 2024 Mar;484:116872
Toxicology and applied pharmacology 2024 Mar;484:116872
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Tang L, Zhang H, Zhou F, Wei Q, Du M, Wu J, Li C, Luo W, Zhou J, Wang X, Chen Z, Zhang Y, Huang Z, Wu Z, Wen Y, Jiang H, Liao D, Kou H, Xiong W, Mei H, Hu Y
Cancer communications (London, England) 2024 Mar;44(3):408-432
Cancer communications (London, England) 2024 Mar;44(3):408-432
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
The roles of gut microbiome and metabolites associated with skin photoaging in mice by intestinal flora sequencing and metabolomics.
Qu L, Ma X, Wang F
Life sciences 2024 Mar 15;341:122487
Life sciences 2024 Mar 15;341:122487
Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.
Li J, Mo JR, Hu SY, Dong X, Li JW, Yang LY, Wu YJ
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Porphyromonas gingivalis Lipopolysaccharide Damages Mucosal Barrier to Promote Gastritis-Associated Carcinogenesis.
Oriuchi M, Lee S, Uno K, Sudo K, Kusano K, Asano N, Hamada S, Hatta W, Koike T, Imatani A, Masamune A
Digestive diseases and sciences 2024 Jan;69(1):95-111
Digestive diseases and sciences 2024 Jan;69(1):95-111
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.
Gao C, Wang Q, Ding Y, Kwong CHT, Liu J, Xie B, Wei J, Lee SMY, Mok GSP, Wang R
Nature communications 2024 Jan 6;15(1):328
Nature communications 2024 Jan 6;15(1):328
Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment.
Liu S, Liu B, Li Q, Zheng T, Liu B, Li M, Chen Z
Neural regeneration research 2024 Feb;19(2):440-446
Neural regeneration research 2024 Feb;19(2):440-446
Hyaluronic Acid-Based Reactive Oxygen Species-Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing.
Shi C, Zhang Y, Wu G, Zhu Z, Zheng H, Sun X, Heng Y, Pan S, Xiu H, Zhang J, Yin Z, Yu Z, Liang B
Advanced healthcare materials 2024 Feb;13(4):e2302626
Advanced healthcare materials 2024 Feb;13(4):e2302626
EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.
Wu J, Xu X, Duan J, Chai Y, Song J, Gong D, Wang B, Hu Y, Han T, Ding Y, Liu Y, Li J, Cao X
Nature communications 2024 Feb 12;15(1):1282
Nature communications 2024 Feb 12;15(1):1282
Huangqi Jiuni decoction prevents acute kidney injury induced by severe burns by inhibiting activation of the TNF/NF-κB pathway.
Hu W, Zhao J, Hu Y, Song S, Chen X, Sun Y
Journal of ethnopharmacology 2024 Feb 10;320:117344
Journal of ethnopharmacology 2024 Feb 10;320:117344
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids.
Chen D, Li G, Luo L, Lin T, Chu X, Liu K, Lai T, Liao Y, Lin X, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156155
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156155
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling.
Yin S, Ma XY, Sun YF, Yin YQ, Long Y, Zhao CL, Ma JW, Li S, Hu Y, Li MT, Hu G, Zhou JW
Journal of neuroinflammation 2023 Sep 6;20(1):203
Journal of neuroinflammation 2023 Sep 6;20(1):203
Ursolic Acid Promotes Autophagy by Inhibiting Akt/mTOR and TNF-α/TNFR1 Signaling Pathways to Alleviate Pyroptosis and Necroptosis in Mycobacterium tuberculosis-Infected Macrophages.
Shen J, Fu Y, Liu F, Ning B, Jiang X
Inflammation 2023 Oct;46(5):1749-1763
Inflammation 2023 Oct;46(5):1749-1763
Exogenous IL-10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis-induced macrophage polarization.
Sawoo R, Dey R, Ghosh R, Bishayi B
Journal of applied toxicology : JAT 2023 Oct;43(10):1549-1572
Journal of applied toxicology : JAT 2023 Oct;43(10):1549-1572
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
Li M, Wei J, Zhu G, Fu S, He X, Hu X, Yu Y, Mou Y, Wang J, You X, Xiao X, Gu T, Ye Z, Zha Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma.
Zhang H, Xia P, Yang Z, Liu J, Zhu Y, Huang Z, Zhang Z, Yuan Y
Clinical and translational medicine 2023 Oct;13(10):e1443
Clinical and translational medicine 2023 Oct;13(10):e1443
Integrated analysis of potential biomarkers associated with diabetic periodontitis development based on bioinformatics: An observational study.
Wu Y, Xing YH, Tao S, Jiao M, Zhu M, Han YT, Guo W, Tao XB
Medicine 2023 Nov 17;102(46):e36019
Medicine 2023 Nov 17;102(46):e36019
Repurposing crizotinib to target RIPK1-dependent cell death.
Yu Y, Li M, Fu S, He X, Hu X, Zhu G, Wang J, You X, Mou Y, Ye Z, Wei J, Zha Y
International immunology 2023 May 8;35(5):221-230
International immunology 2023 May 8;35(5):221-230
Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis.
Zhang L, Li L, Chen X, Yuan S, Xu T, Zhao W, Li M, Wang F, Hoffman RM, Jia L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154493
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154493
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line.
Li B, Lu Y, Wang R, Xu T, Lei X, Jin H, Gao X, Xie Y, Liu X, Zeng J
Neurochemical research 2023 Feb;48(2):519-536
Neurochemical research 2023 Feb;48(2):519-536
TNFα/TNFR1 signal induces excessive senescence of decidua stromal cells in recurrent pregnancy loss.
Zeng S, Liang Y, Lai S, Bi S, Huang L, Li Y, Deng W, Xu P, Liu M, Xiong Z, Chen J, Tu Z, Chen D, Du L
Journal of reproductive immunology 2023 Feb;155:103776
Journal of reproductive immunology 2023 Feb;155:103776
Repositioning linifanib as a potent anti-necroptosis agent for sepsis.
Yu L, Yang K, He X, Li M, Gao L, Zha Y
Cell death discovery 2023 Feb 10;9(1):57
Cell death discovery 2023 Feb 10;9(1):57
Plasma soluble tumor necrosis factor receptor I as a biomarker of lupus nephritis and disease activity in systemic lupus erythematosus patients.
Liu XR, Qi YY, Zhao YF, Cui Y, Zhao ZZ
Renal failure 2023 Dec;45(1):2174355
Renal failure 2023 Dec;45(1):2174355
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling.
Ye HY, Song YL, Ye WT, Xiong CX, Li JM, Miao JH, Shen WW, Li XL, Zhou LL
Acta pharmacologica Sinica 2023 Dec;44(12):2432-2444
Acta pharmacologica Sinica 2023 Dec;44(12):2432-2444
Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.
Liu K, Chai L, Zhao T, Zhang S, Wang J, Yu Y, Niu R, Sun Z
Biological trace element research 2023 Dec;201(12):5734-5746
Biological trace element research 2023 Dec;201(12):5734-5746
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
Wang X, Gao F, Cheng C, Zhang Y
Functional & integrative genomics 2023 Dec 8;24(1):1
Functional & integrative genomics 2023 Dec 8;24(1):1
EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.
Zhang H, Zhang X, Ling C, Liu C, Hua S, Xiong Z, Zhao H, Feng Q, Feng Z, Tang J, Hong X
International immunopharmacology 2023 Apr;117:109902
International immunopharmacology 2023 Apr;117:109902
Finerenone attenuates myocardial apoptosis, metabolic disturbance and myocardial fibrosis in type 2 diabetes mellitus.
Jin T, Fu X, Liu M, An F
Diabetology & metabolic syndrome 2023 Apr 29;15(1):87
Diabetology & metabolic syndrome 2023 Apr 29;15(1):87
Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis.
Yuan S, Pan Y, Xu T, Zhang L, Chen X, Wang F, Liu Q, Jia L
Oxidative medicine and cellular longevity 2022;2022:5382263
Oxidative medicine and cellular longevity 2022;2022:5382263
Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: A network pharmacology study and in vivo experimental validation.
Lei S, Zhao S, Huang X, Feng Y, Li Z, Chen L, Huang P, Guan H, Zhang H, Wu Q, Chen B
Frontiers in pharmacology 2022;13:967623
Frontiers in pharmacology 2022;13:967623
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.
Wang X, Liu XQ, Jiang L, Huang YB, Zeng HX, Zhu QJ, Qi XM, Wu YG
Frontiers in pharmacology 2022;13:966645
Frontiers in pharmacology 2022;13:966645
Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer.
Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C
Cancer cell 2022 Sep 12;40(9):1044-1059.e8
Cancer cell 2022 Sep 12;40(9):1044-1059.e8
MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis.
Cui Y, Wang X, Lin F, Li W, Zhao Y, Zhu F, Yang H, Rao M, Li Y, Liang H, Dai M, Liu B, Chen L, Han D, Lu R, Peng W, Zhang Y, Song C, Luo Y, Pan P
Aging and disease 2022 Jun;13(3):899-909
Aging and disease 2022 Jun;13(3):899-909
Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.
Fan XZ, Wang YY, Cui ZY, Cheng ZH, Zhang HL, Gamper N, Zhang F, Han M
Free radical biology & medicine 2022 Jan;178:111-124
Free radical biology & medicine 2022 Jan;178:111-124
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.
Lu D, Lin Z, Wang R, Chen Z, Zhuo J, Xu L, Pan L, Li H, Yang X, He C, Shen W, Yang M, Li H, Chen H, Tan W, Wei X, Zheng S, Xu X
Redox biology 2022 Dec;58:102538
Redox biology 2022 Dec;58:102538
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Sha X, Dai Y, Chong L, Wei M, Xing M, Zhang C, Li J
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.
Yu H, Li M, Wen X, Yang J, Liang X, Li X, Bao X, Shu J, Ren X, Chen W, Li Z, Li Y
Arthritis research & therapy 2022 Apr 29;24(1):93
Arthritis research & therapy 2022 Apr 29;24(1):93
The Impact of β-1,4-Galactosyltransferase V on Microglial Function.
Wang X, Shi N, Hui M, Jin H, Gao S, Zhou Q, Zhang L, Yan M, Shen H
Frontiers in cellular neuroscience 2021;15:723308
Frontiers in cellular neuroscience 2021;15:723308
Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension.
Wang F, Sun C, Lv X, Sun M, Si C, Zhen Y, Guo J, Sun W, Ye Z, Wen J, Liu P
Frontiers in physiology 2021;12:744219
Frontiers in physiology 2021;12:744219
Effect of pyrroloquinoline quinone on lipopolysaccharide-induced autophagy in HAPI microglia cells.
Gao S, Zhou Q, Jin H, Shi N, Wang X, Zhang L, Yan M
Annals of translational medicine 2021 Sep;9(17):1377
Annals of translational medicine 2021 Sep;9(17):1377
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.
Shi R, Shi X, Qin D, Tang S, Vermeulen M, Zhang X
Cell & bioscience 2021 Jul 27;11(1):146
Cell & bioscience 2021 Jul 27;11(1):146
A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
Zhang Y, Huang K, Zhang Y, Han T, Li L, Ruan C, Sun YH, Shi W, Han W, Wu SQ, Song J, Liu J, Han J
PLoS biology 2021 Aug;19(8):e3001304
PLoS biology 2021 Aug;19(8):e3001304
Orientia tsutsugamushi modulates cellular levels of NF-κB inhibitor p105.
Wangsanut T, Brann KR, Adcox HE, Carlyon JA
PLoS neglected tropical diseases 2021 Apr;15(4):e0009339
PLoS neglected tropical diseases 2021 Apr;15(4):e0009339
The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota.
Zhang B, Yue R, Chen Y, Huang X, Yang M, Shui J, Peng Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:4568629
Evidence-based complementary and alternative medicine : eCAM 2020;2020:4568629
Cerebral Immunohistochemical Characterization of the H(2)S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.
Denoix N, Merz T, Unmuth S, Hoffmann A, Nespoli E, Scheuerle A, Huber-Lang M, Gündel H, Waller C, Radermacher P, McCook O
Frontiers in neurology 2020;11:649
Frontiers in neurology 2020;11:649
KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
Wang B, Jing T, Jin W, Chen J, Wu C, Wang M, Liu Y
Journal of experimental & clinical cancer research : CR 2020 Aug 27;39(1):170
Journal of experimental & clinical cancer research : CR 2020 Aug 27;39(1):170
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.
Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H
The Journal of clinical investigation 2019 May 21;129(8):3103-3120
The Journal of clinical investigation 2019 May 21;129(8):3103-3120
The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.
Egusquiaguirre SP, Yeh JE, Walker SR, Liu S, Frank DA
Neoplasia (New York, N.Y.) 2018 May;20(5):489-498
Neoplasia (New York, N.Y.) 2018 May;20(5):489-498
Lymphotoxins Promote the Progression of Human Lymphatic Malformation by Enhancing Lymphatic Endothelial Cell Proliferation.
Yang JG, Sun YF, He KF, Ren JG, Liu ZJ, Liu B, Zhang W, Zhao YF
The American journal of pathology 2017 Nov;187(11):2602-2615
The American journal of pathology 2017 Nov;187(11):2602-2615
TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3.
Chang X, Wang L, Wang Z, Wu S, Zhu X, Hu S, Wang Y, Yu J, Chen G
Scientific reports 2017 Nov 23;7(1):16111
Scientific reports 2017 Nov 23;7(1):16111
Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.
Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters 2017 Nov 1;408:60-70
Cancer letters 2017 Nov 1;408:60-70
Tripartite motif-containing 28 bridges endothelial inflammation and angiogenic activity by retaining expression of TNFR-1 and -2 and VEGFR2 in endothelial cells.
Wang Y, Li J, Huang Y, Dai X, Liu Y, Liu Z, Wang Y, Wang N, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 May;31(5):2026-2036
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 May;31(5):2026-2036
Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells.
Molino Y, Jabès F, Bonnet A, Gaudin N, Bernard A, Benech P, Khrestchatisky M
Journal of neuroinflammation 2016 Nov 10;13(1):290
Journal of neuroinflammation 2016 Nov 10;13(1):290
Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.
Nie D, Zhang D, Dai J, Zhang M, Zhao X, Xu W, Chen Z, Wang L, Wang Z, Qiao Z
Biology of reproduction 2016 Feb;94(2):31
Biology of reproduction 2016 Feb;94(2):31
Effect of acute lipopolysaccharide-induced inflammation in intracerebroventricular-streptozotocin injected rats.
Murtishaw AS, Heaney CF, Bolton MM, Sabbagh JJ, Langhardt MA, Kinney JW
Neuropharmacology 2016 Feb;101:110-22
Neuropharmacology 2016 Feb;101:110-22
Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo.
Yang T, Shi R, Chang L, Tang K, Chen K, Yu G, Tian Y, Guo Y, He W, Song X, Xu H, Ye Z
Journal of experimental & clinical cancer research : CR 2015 Feb 25;34(1):21
Journal of experimental & clinical cancer research : CR 2015 Feb 25;34(1):21
Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.
Kallenborn-Gerhardt W, Hohmann SW, Syhr KM, Schröder K, Sisignano M, Weigert A, Lorenz JE, Lu R, Brüne B, Brandes RP, Geisslinger G, Schmidtko A
Pain 2014 Oct;155(10):2161-70
Pain 2014 Oct;155(10):2161-70
TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.
Zhang C, Wang C, Tang S, Sun Y, Zhao D, Zhang S, Deng S, Zhou Y, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:825-38
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:825-38
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TNFR1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TNFR1. This antibody recognizes human, mouse antigen. The TNFR1 antibody has been validated for the following applications: ELISA, WB analysis.
