21574-1-AP

antibody from Proteintech Group

Targeting: TNFRSF1A CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60

Provider product page for 21574-1-AP

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Antibody data

Antibody Data
Antigen structure
References [56]
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Validations
Western blot [1]

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Product number: 21574-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21574-1-AP, RRID:AB_10734433
Product name: TNFR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated TNFR1 antibody (Cat. #21574-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TNFRSF1A protein structure - 21574-1-AP shown in red.

Submitted references Tetramethylpyrazine inhibits the inflammatory response by downregulating the TNFR1/IκB-α/NF-κB p65 pathway after spinal cord injury.

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Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.

Tang L, Zhang H, Zhou F, Wei Q, Du M, Wu J, Li C, Luo W, Zhou J, Wang X, Chen Z, Zhang Y, Huang Z, Wu Z, Wen Y, Jiang H, Liao D, Kou H, Xiong W, Mei H, Hu Y
Cancer communications (London, England) 2024 Mar;44(3):408-432

TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.

Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
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The roles of gut microbiome and metabolites associated with skin photoaging in mice by intestinal flora sequencing and metabolomics.

Qu L, Ma X, Wang F
Life sciences 2024 Mar 15;341:122487

Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.

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Porphyromonas gingivalis Lipopolysaccharide Damages Mucosal Barrier to Promote Gastritis-Associated Carcinogenesis.

Oriuchi M, Lee S, Uno K, Sudo K, Kusano K, Asano N, Hamada S, Hatta W, Koike T, Imatani A, Masamune A
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Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment.

Liu S, Liu B, Li Q, Zheng T, Liu B, Li M, Chen Z
Neural regeneration research 2024 Feb;19(2):440-446

Hyaluronic Acid-Based Reactive Oxygen Species-Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing.

Shi C, Zhang Y, Wu G, Zhu Z, Zheng H, Sun X, Heng Y, Pan S, Xiu H, Zhang J, Yin Z, Yu Z, Liang B
Advanced healthcare materials 2024 Feb;13(4):e2302626

EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.

Wu J, Xu X, Duan J, Chai Y, Song J, Gong D, Wang B, Hu Y, Han T, Ding Y, Liu Y, Li J, Cao X
Nature communications 2024 Feb 12;15(1):1282

Huangqi Jiuni decoction prevents acute kidney injury induced by severe burns by inhibiting activation of the TNF/NF-κB pathway.

Hu W, Zhao J, Hu Y, Song S, Chen X, Sun Y
Journal of ethnopharmacology 2024 Feb 10;320:117344

RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling.

Yin S, Ma XY, Sun YF, Yin YQ, Long Y, Zhao CL, Ma JW, Li S, Hu Y, Li MT, Hu G, Zhou JW
Journal of neuroinflammation 2023 Sep 6;20(1):203

Ursolic Acid Promotes Autophagy by Inhibiting Akt/mTOR and TNF-α/TNFR1 Signaling Pathways to Alleviate Pyroptosis and Necroptosis in Mycobacterium tuberculosis-Infected Macrophages.

Shen J, Fu Y, Liu F, Ning B, Jiang X
Inflammation 2023 Oct;46(5):1749-1763

Exogenous IL-10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis-induced macrophage polarization.

Sawoo R, Dey R, Ghosh R, Bishayi B
Journal of applied toxicology : JAT 2023 Oct;43(10):1549-1572

Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.

Li M, Wei J, Zhu G, Fu S, He X, Hu X, Yu Y, Mou Y, Wang J, You X, Xiao X, Gu T, Ye Z, Zha Y
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Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma.

Zhang H, Xia P, Yang Z, Liu J, Zhu Y, Huang Z, Zhang Z, Yuan Y
Clinical and translational medicine 2023 Oct;13(10):e1443

Integrated analysis of potential biomarkers associated with diabetic periodontitis development based on bioinformatics: An observational study.

Wu Y, Xing YH, Tao S, Jiao M, Zhu M, Han YT, Guo W, Tao XB
Medicine 2023 Nov 17;102(46):e36019

Repurposing crizotinib to target RIPK1-dependent cell death.

Yu Y, Li M, Fu S, He X, Hu X, Zhu G, Wang J, You X, Mou Y, Ye Z, Wei J, Zha Y
International immunology 2023 May 8;35(5):221-230

Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis.

Zhang L, Li L, Chen X, Yuan S, Xu T, Zhao W, Li M, Wang F, Hoffman RM, Jia L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154493

MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line.

Li B, Lu Y, Wang R, Xu T, Lei X, Jin H, Gao X, Xie Y, Liu X, Zeng J
Neurochemical research 2023 Feb;48(2):519-536

TNFα/TNFR1 signal induces excessive senescence of decidua stromal cells in recurrent pregnancy loss.

Zeng S, Liang Y, Lai S, Bi S, Huang L, Li Y, Deng W, Xu P, Liu M, Xiong Z, Chen J, Tu Z, Chen D, Du L
Journal of reproductive immunology 2023 Feb;155:103776

Repositioning linifanib as a potent anti-necroptosis agent for sepsis.

Yu L, Yang K, He X, Li M, Gao L, Zha Y
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Liu XR, Qi YY, Zhao YF, Cui Y, Zhao ZZ
Renal failure 2023 Dec;45(1):2174355

Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling.

Ye HY, Song YL, Ye WT, Xiong CX, Li JM, Miao JH, Shen WW, Li XL, Zhou LL
Acta pharmacologica Sinica 2023 Dec;44(12):2432-2444

Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.

Liu K, Chai L, Zhao T, Zhang S, Wang J, Yu Y, Niu R, Sun Z
Biological trace element research 2023 Dec;201(12):5734-5746

Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.

Wang X, Gao F, Cheng C, Zhang Y
Functional & integrative genomics 2023 Dec 8;24(1):1

EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.

Zhang H, Zhang X, Ling C, Liu C, Hua S, Xiong Z, Zhao H, Feng Q, Feng Z, Tang J, Hong X
International immunopharmacology 2023 Apr;117:109902

Finerenone attenuates myocardial apoptosis, metabolic disturbance and myocardial fibrosis in type 2 diabetes mellitus.

Jin T, Fu X, Liu M, An F
Diabetology & metabolic syndrome 2023 Apr 29;15(1):87

Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis.

Yuan S, Pan Y, Xu T, Zhang L, Chen X, Wang F, Liu Q, Jia L
Oxidative medicine and cellular longevity 2022;2022:5382263

Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: A network pharmacology study and in vivo experimental validation.

Lei S, Zhao S, Huang X, Feng Y, Li Z, Chen L, Huang P, Guan H, Zhang H, Wu Q, Chen B
Frontiers in pharmacology 2022;13:967623

Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.

Wang X, Liu XQ, Jiang L, Huang YB, Zeng HX, Zhu QJ, Qi XM, Wu YG
Frontiers in pharmacology 2022;13:966645

Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer.

Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C
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MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis.

Cui Y, Wang X, Lin F, Li W, Zhao Y, Zhu F, Yang H, Rao M, Li Y, Liang H, Dai M, Liu B, Chen L, Han D, Lu R, Peng W, Zhang Y, Song C, Luo Y, Pan P
Aging and disease 2022 Jun;13(3):899-909

Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.

Fan XZ, Wang YY, Cui ZY, Cheng ZH, Zhang HL, Gamper N, Zhang F, Han M
Free radical biology & medicine 2022 Jan;178:111-124

Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.

Lu D, Lin Z, Wang R, Chen Z, Zhuo J, Xu L, Pan L, Li H, Yang X, He C, Shen W, Yang M, Li H, Chen H, Tan W, Wei X, Zheng S, Xu X
Redox biology 2022 Dec;58:102538

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.

Sha X, Dai Y, Chong L, Wei M, Xing M, Zhang C, Li J
Journal of nanobiotechnology 2022 Dec 1;20(1):506

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.

Yu H, Li M, Wen X, Yang J, Liang X, Li X, Bao X, Shu J, Ren X, Chen W, Li Z, Li Y
Arthritis research & therapy 2022 Apr 29;24(1):93

The Impact of β-1,4-Galactosyltransferase V on Microglial Function.

Wang X, Shi N, Hui M, Jin H, Gao S, Zhou Q, Zhang L, Yan M, Shen H
Frontiers in cellular neuroscience 2021;15:723308

Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension.

Wang F, Sun C, Lv X, Sun M, Si C, Zhen Y, Guo J, Sun W, Ye Z, Wen J, Liu P
Frontiers in physiology 2021;12:744219

Effect of pyrroloquinoline quinone on lipopolysaccharide-induced autophagy in HAPI microglia cells.

Gao S, Zhou Q, Jin H, Shi N, Wang X, Zhang L, Yan M
Annals of translational medicine 2021 Sep;9(17):1377

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

Shi R, Shi X, Qin D, Tang S, Vermeulen M, Zhang X
Cell & bioscience 2021 Jul 27;11(1):146

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.

Zhang Y, Huang K, Zhang Y, Han T, Li L, Ruan C, Sun YH, Shi W, Han W, Wu SQ, Song J, Liu J, Han J
PLoS biology 2021 Aug;19(8):e3001304

Orientia tsutsugamushi modulates cellular levels of NF-κB inhibitor p105.

Wangsanut T, Brann KR, Adcox HE, Carlyon JA
PLoS neglected tropical diseases 2021 Apr;15(4):e0009339

The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota.

Zhang B, Yue R, Chen Y, Huang X, Yang M, Shui J, Peng Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:4568629

KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.

Wang B, Jing T, Jin W, Chen J, Wu C, Wang M, Liu Y
Journal of experimental & clinical cancer research : CR 2020 Aug 27;39(1):170

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H
The Journal of clinical investigation 2019 May 21;129(8):3103-3120

The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.

Egusquiaguirre SP, Yeh JE, Walker SR, Liu S, Frank DA
Neoplasia (New York, N.Y.) 2018 May;20(5):489-498

Lymphotoxins Promote the Progression of Human Lymphatic Malformation by Enhancing Lymphatic Endothelial Cell Proliferation.

Yang JG, Sun YF, He KF, Ren JG, Liu ZJ, Liu B, Zhang W, Zhao YF
The American journal of pathology 2017 Nov;187(11):2602-2615

TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3.

Chang X, Wang L, Wang Z, Wu S, Zhu X, Hu S, Wang Y, Yu J, Chen G
Scientific reports 2017 Nov 23;7(1):16111

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters 2017 Nov 1;408:60-70

Tripartite motif-containing 28 bridges endothelial inflammation and angiogenic activity by retaining expression of TNFR-1 and -2 and VEGFR2 in endothelial cells.

Wang Y, Li J, Huang Y, Dai X, Liu Y, Liu Z, Wang Y, Wang N, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 May;31(5):2026-2036

Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells.

Molino Y, Jabès F, Bonnet A, Gaudin N, Bernard A, Benech P, Khrestchatisky M
Journal of neuroinflammation 2016 Nov 10;13(1):290

Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.

Nie D, Zhang D, Dai J, Zhang M, Zhao X, Xu W, Chen Z, Wang L, Wang Z, Qiao Z
Biology of reproduction 2016 Feb;94(2):31

Effect of acute lipopolysaccharide-induced inflammation in intracerebroventricular-streptozotocin injected rats.

Murtishaw AS, Heaney CF, Bolton MM, Sabbagh JJ, Langhardt MA, Kinney JW
Neuropharmacology 2016 Feb;101:110-22

Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo.

Yang T, Shi R, Chang L, Tang K, Chen K, Yu G, Tian Y, Guo Y, He W, Song X, Xu H, Ye Z
Journal of experimental & clinical cancer research : CR 2015 Feb 25;34(1):21

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Kallenborn-Gerhardt W, Hohmann SW, Syhr KM, Schröder K, Sisignano M, Weigert A, Lorenz JE, Lu R, Brüne B, Brandes RP, Geisslinger G, Schmidtko A
Pain 2014 Oct;155(10):2161-70

TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.

Zhang C, Wang C, Tang S, Sun Y, Zhao D, Zhang S, Deng S, Zhou Y, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:825-38

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TNFR1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TNFR1. This antibody recognizes human, mouse antigen. The TNFR1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 21574-1-AP.pdf

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