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- Antigen structure
- References [15]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 22589-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- PRICKLE1 antibody
- Antibody type
- Polyclonal
- Description
- PRICKLE1 antibody (Cat. #22589-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Differential sensitivity of midline development to mitosis during and after primitive streak extension.
Regulatory role for tumor suppressor REST on estrogen receptor (ESR1) expression and leiomyoma pathophysiology.
Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity.
PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins.
Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves.
Regulatory Role for Tumor Suppressor REST on Estrogen Receptor (ESR1) Expression and Leiomyoma Pathophysiology.
Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension.
Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.
Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.
Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production.
Mutation of the murine Prickle1 (R104Q) causes phenotypes analogous to human symptoms of epilepsy and autism.
Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex.
PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia.
The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2.
Coupling of apical-basal polarity and planar cell polarity to interpret the Wnt signaling gradient in feather development.
Zhao Z, Asai R, Mikawa T
Developmental dynamics : an official publication of the American Association of Anatomists 2026 May;255(5):486-502
Developmental dynamics : an official publication of the American Association of Anatomists 2026 May;255(5):486-502
Regulatory role for tumor suppressor REST on estrogen receptor (ESR1) expression and leiomyoma pathophysiology.
Bird SG, Gunewardena S, Cloud A, Ganeshkumar S, Chennathukuzhi VM
The Journal of biological chemistry 2026 Jan;302(1):111017
The Journal of biological chemistry 2026 Jan;302(1):111017
Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity.
Wang JX, Alvarez YD, Tan SZ, Ranie SN, Stehbens SJ, White MD
Nature communications 2026 Apr 27;17(1)
Nature communications 2026 Apr 27;17(1)
PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins.
Wang L, Bu T, Gao S, Yun D, Chen H, Cheng CY, Sun F
American journal of physiology. Cell physiology 2025 Jun 1;328(6):C2032-C2056
American journal of physiology. Cell physiology 2025 Jun 1;328(6):C2032-C2056
Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves.
Suzuki T, Naito K, Kubota D, Ueno Y, Negishi-Koga T, Yamamoto Y, Kawakita S, Imazu N, Kawamura K, Hattori N, Ishijima M
Molecular medicine reports 2025 Dec;32(6)
Molecular medicine reports 2025 Dec;32(6)
Regulatory Role for Tumor Suppressor REST on Estrogen Receptor (ESR1) Expression and Leiomyoma Pathophysiology.
Bird SG, Gunewardena S, Cloud A, Ganeshkumar S, Chennathukuzhi VM
bioRxiv : the preprint server for biology 2025 Aug 31;
bioRxiv : the preprint server for biology 2025 Aug 31;
Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension.
Zhao Z, Asai R, Mikawa T
bioRxiv : the preprint server for biology 2024 Oct 26;
bioRxiv : the preprint server for biology 2024 Oct 26;
Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.
Asai R, Prakash VN, Sinha S, Prakash M, Mikawa T
eLife 2024 May 10;12
eLife 2024 May 10;12
Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.
Asai R, Prakash VN, Sinha S, Prakash M, Mikawa T
bioRxiv : the preprint server for biology 2024 Feb 1;
bioRxiv : the preprint server for biology 2024 Feb 1;
Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production.
Borges KS, Little DW 3rd, Magalhães TA, Ribeiro C, Dumontet T, Lapensee C, Basham KJ, Seth A, Azova S, Guagliardo NA, Barrett PQ, Berber M, O'Connell AE, Turcu AF, Lerario AM, Mohan DR, Rainey W, Carlone DL, Hirschhorn JN, Salic A, Breault DT, Hammer GD
bioRxiv : the preprint server for biology 2024 Aug 24;
bioRxiv : the preprint server for biology 2024 Aug 24;
Mutation of the murine Prickle1 (R104Q) causes phenotypes analogous to human symptoms of epilepsy and autism.
Ban Y, Yu T, Wang J, Wang X, Liu C, Baker C, Zou Y
Experimental neurology 2022 Jan;347:113880
Experimental neurology 2022 Jan;347:113880
Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex.
Ban Y, Yu T, Feng B, Lorenz C, Wang X, Baker C, Zou Y
Science advances 2021 Oct 8;7(41):eabh2974
Science advances 2021 Oct 8;7(41):eabh2974
PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia.
Jiang D, He Y, Mo Q, Liu E, Li X, Huang L, Zhang Q, Chen F, Li Y, Shao H
Journal of translational medicine 2021 May 17;19(1):211
Journal of translational medicine 2021 May 17;19(1):211
The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2.
Jarjour AA, Velichkova AN, Boyd A, Lord KM, Torsney C, Henderson DJ, Ffrench-Constant C
Glia 2020 Sep;68(9):1840-1858
Glia 2020 Sep;68(9):1840-1858
Coupling of apical-basal polarity and planar cell polarity to interpret the Wnt signaling gradient in feather development.
Lin J, Yue Z
Development (Cambridge, England) 2018 Sep 14;145(17)
Development (Cambridge, England) 2018 Sep 14;145(17)
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 22589-1-AP(PRICKLE1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRICKLE1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PRICKLE1. This antibody recognizes human, mouse antigen. The PRICKLE1 antibody has been validated for the following applications: ELISA, WB, IP analysis.
