15503-1-AP

antibody from Proteintech Group

Targeting: NFKB2 LYT-10, NF-kB2, p105, p49/p100, p52

Provider product page for 15503-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [14]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 15503-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15503-1-AP, RRID:AB_2267126
Product name: NFKB2,p52,p100-Specific antibody
Antibody type: Polyclonal
Description: NFKB2,p52,p100-Specific antibody (Cat. #15503-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NFKB2 protein structure - 15503-1-AP shown in red.

Submitted references An HHEX/IKKα positive feedback loop promotes intestinal inflammation.

Hua Z, Xu W, Ding W, Fu Z, Wang Y, Yang Y, Liu F, Dai Z, Tang W, Ou W, Ge W, Chen Y, Wang Z, Liu CY, Du P
The Journal of clinical investigation 2026 May 15;136(10)

Migration and invasion inhibitory protein inhibits M2 macrophage polarization to suppress colorectal cancer progression through the STING-NFκB2-IL10 axis.

Chen S, Lu C, Li J, Shen X, Sun Y
Cancer biology & medicine 2026 Jan 14;23(1):86-106

KLF10 Induced by Hypothermic Machine Perfusion Alleviates Renal Inflammation Through BIRC2 /Noncanonical NF-κB Pathway.

Hu Q, Chen H, Lan J, Chen Y, Liu Z, Xiong Y, Zhou W, Zhong Z, Ye Q
Transplantation 2025 Jun 1;109(6):e273-e286

c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT.

Bakırdöğen D, Görgülü K, Xin J, Richter L, Alcalá S, Ruiz-Cañas L, Dai C, Frank KJ, Wu N, Diakopoulos KN, Ozturk H, Demircioğlu D, Peschke K, Ranjan R, Fusco F, Martinez-Useros J, Fernandez-Aceñero MJ, Chhabra NF, López-Gil JC, Ai J, Ruess DA, Kaya-Aksoy E, Schmidt F, Kohlmann L, Berninger A, Yang H, Schicktanz F, Steiger K, Demir IE, Schmid RM, Reichert M, Adli M, Lesina M, Sainz B Jr, Algül H
Molecular cancer 2025 Dec 15;25(1):16

D-Mannose Upregulates Testin via the NF-κB Pathway to Inhibit Breast Cancer Proliferation.

Cao X, Liu X, Chen P, Wei T, Zhou Q, Zhang G, She T, Wang Z, Liu Y
Journal of biochemical and molecular toxicology 2025 Aug;39(8):e70398

Development of RelB-targeting small-molecule inhibitors of non-canonical NF-κB signaling with antitumor efficacy.

Li C, Wei S, Sun D, Yang Z, Wang Q, Lin H, Zhang H, Hu Y, Liu D, Ye D, Tao Y, Liu Z, Xu Z, Li B, Li L, Zhang J, Chen X, Xie N, Shi Y, Liu S, Liu Y, Jiang Y, Zhu W, Zhang X
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Apr 2;33(4):1519-1534

Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer.

Yu J, Zhang M, Li T, Gao W, Yang Z, Wang K, Liu Z, Zhu S, Wen S, Zhao Y, Cai Q, Shang Z, Wang Y, Niu Y
Oncogene 2024 Sep;43(38):2835-2849

Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection.

Wang Y, Zhao X, Li Z, Wang W, Jiang Y, Zhang H, Liu X, Ren Y, Xu X, Hu X
Communications biology 2024 May 31;7(1):669

Platelet membrane-coated alterbrassicene A nanoparticle inhibits calcification of the aortic valve by suppressing phosphorylation P65 NF-κB.

Geng B, Chen X, Chi J, Li F, Yim WY, Wang K, Li C, Xie M, Zhu P, Fan Z, Shi J, Hu Z, Zhang Y, Dong N
Theranostics 2023;13(11):3781-3793

Interleukin-1 increases cyclooxygenase-2 expression and prostaglandin E2 production in human granulosa-lutein cell via nuclear factor kappa B/P65 and extracellular signal-regulated kinase 1/2 signaling pathways.

Wan S, Chen Q, Xiang Y, Sang Y, Tang M, Song Y, Feng G, Ye B, Bai L, Zhu Y
Molecular and cellular endocrinology 2023 May 1;566-567:111891

Characterization of the Roles of Suppressor of Cytokine Signaling-3 in Esophageal Carcinoma.

Yang X, Tian M, Lin Y, Li L, Sun X, Zhang Z, Kang M, Lin J
Human gene therapy 2023 Jun;34(11-12):495-517

Identification of Prognostic Markers of Gynecologic Cancers Utilizing Patient-Derived Xenograft Mouse Models.

Shin HY, Lee EJ, Yang W, Kim HS, Chung D, Cho H, Kim JH
Cancers 2022 Feb 6;14(3)

Simiao Qingwen Baidu decoction inhibits Epstein-Barr virus-induced B lymphoproliferative disease and lytic viral replication.

Yang X, Liu L, Zhang H, Sun X, Yan Y, Ran R
Pharmaceutical biology 2021 Dec;59(1):741-747

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway.

Wang J, Ferreira R, Lu W, Farrow S, Downes K, Jermutus L, Minter R, Al-Lamki RS, Pober JS, Bradley JR
Scientific reports 2018 Aug 13;8(1):12079

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A431 cells were subjected to SDS PAGE followed by western blot with 15503-1-AP( NFKB2,p52,p100-Specific Antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The NFKB2,p52,p100-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human NFKB2,p52,p100-Specific. This antibody recognizes human, mouse antigen. The NFKB2,p52,p100-Specific antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 15503-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human spleen using 15503-1-AP(NFKB2,p52,p100-Specific antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue