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- Antigen structure
- References [8]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 18195-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18195-1-AP, RRID:AB_2280998
- Product name
- LACTB antibody
- Antibody type
- Polyclonal
- Description
- LACTB antibody (Cat. #18195-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.
LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway.
Clinical Significance of β-Lactamase Expression in Colorectal Cancer.
LACTB mRNA expression is increased in pancreatic adenocarcinoma and high expression indicates a poor prognosis.
LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation.
LACTB is a tumour suppressor that modulates lipid metabolism and cell state.
Ma W, Sun Y, Yan R, Zhang P, Shen S, Lu H, Zhou Z, Jiang Z, Ye L, Mao Q, Xiong N, Jia W, Sun L, Gao P, Zhang H
Molecular cell 2024 Feb 1;84(3):538-551.e7
Molecular cell 2024 Feb 1;84(3):538-551.e7
LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
Cutano V, Ferreira Mendes JM, Escudeiro-Lopes S, Machado S, Vinaixa Forner J, Gonzales-Morena JM, Prevorovsky M, Zemlianski V, Feng Y, Kralova Viziova P, Hartmanova A, Malcekova B, Jakoube P, Iyer S, Keckesova Z
Life science alliance 2023 Jan;6(1)
Life science alliance 2023 Jan;6(1)
LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.
Gonzalez-Morena JM, Escudeiro-Lopes S, Ferreira-Mendes JM, Jakoube P, Cutano V, Vinaixa-Forner J, Kralova Viziova P, Hartmanova A, Sedlacek R, Machado S, Malcekova B, Keckesova Z
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):186-198
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):186-198
LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway.
Xu Y, Shi H, Wang M, Huang P, Xu M, Han S, Li H, Wang Y
Experimental and therapeutic medicine 2022 Mar;23(3):247
Experimental and therapeutic medicine 2022 Mar;23(3):247
Clinical Significance of β-Lactamase Expression in Colorectal Cancer.
Zhou S, Miao L, Li T, Liu P, Zhou H
Cancer biotherapy & radiopharmaceuticals 2022 Dec;37(10):939-944
Cancer biotherapy & radiopharmaceuticals 2022 Dec;37(10):939-944
LACTB mRNA expression is increased in pancreatic adenocarcinoma and high expression indicates a poor prognosis.
Xie J, Peng Y, Chen X, Li Q, Jian B, Wen Z, Liu S
PloS one 2021;16(1):e0245908
PloS one 2021;16(1):e0245908
LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation.
Zeng K, Chen X, Hu X, Liu X, Xu T, Sun H, Pan Y, He B, Wang S
Oncogene 2018 Oct;37(41):5534-5551
Oncogene 2018 Oct;37(41):5534-5551
LACTB is a tumour suppressor that modulates lipid metabolism and cell state.
Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt F, Thiru P, Golub TR, Vance JE, Weinberg RA
Nature 2017 Mar 30;543(7647):681-686
Nature 2017 Mar 30;543(7647):681-686
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 18195-1-AP(LACTB antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 18195-1-AP(LACTB antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LACTB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LACTB. This antibody recognizes human, mouse, rat antigen. The LACTB antibody has been validated for the following applications: ELISA, WB, IHC analysis.
