CELSR3

This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

Description

Cadherin EGF LAG seven-pass G-type receptor 3

Tissue specificity

Tissue enhanced (brain, pituitary gland, retina)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (48636463 - 48662886)

Ensembl ID

ENSG00000008300  (ver. 103.38)

Orthologs

Mouse Celsr3: ENSMUSG00000023473

UniProt

Q9NYQ7

neXtProt

NX_Q9NYQ7

Human splice variants
Mouse splice variants

Protein structure