BS9177

antibody from Bioworld Technology, Inc

Targeting: MPRIP M-RIP, p116Rip, RHOIP3

Western blot (Data presented on provider website)

Antibody Data

Product number

BS9177

Provider

Bioworld Technology, Inc

Product name

M RIP (E785) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 756-801 of Human M-RIP.

Description

M-RIP (myosin phosphatase Rho interacting protein), also known as MPRIP, p116Rip, RIP3 or RHOIP3, is a 1,025 amino acid cytoplasmic and cytoskeletal protein that is required for regulation of the actin cytoskeleton. M-RIP colocalizes with myosin binding subunit (MBS) to regulate the phosphorylation of myosin light chain, and colocalizes with F-actin through its N-terminus in the cytoskeleton. M-RIP also interacts with and RhoA at actin stress fibers via its adjacent coiled coil domains. M-RIP is highly expressed in ovary, with moderate levels found in brain, heart, liver, lung, skeletal muscle, testis and kidney. M-RIP depletion causes an increase of stress fibers in smooth muscle cells, whereas M-RIP over-expression causes disassembly of stress fibers in neuronal cells.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.