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Learn25196-1-AP
antibody from Proteintech Group
Targeting: TUT7
FLJ13409, KIAA1711, PAPD6, TENT3B, ZCCHC6
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 25196-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ZCCHC6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ZCCHC6 antibody (Cat. #25196-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
MiRNA post-transcriptional modification dynamics in T cell activation.
The molecular basis of coupling between poly(A)-tail length and translational efficiency.
Identification of RNA-binding proteins that partner with Lin28a to regulate Dnmt3a expression.
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2.
A Mechanism for microRNA Arm Switching Regulated by Uridylation.
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
3' Uridylation controls mature microRNA turnover during CD4 T-cell activation.
TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA.
Yang A, Bofill-De Ros X, Stanton R, Shao TJ, Villanueva P, Gu S
Nature communications 2022 Sep 7;13(1):5260
Nature communications 2022 Sep 7;13(1):5260
RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska EA
RNA (New York, N.Y.) 2022 Mar;28(3):353-370
RNA (New York, N.Y.) 2022 Mar;28(3):353-370
MiRNA post-transcriptional modification dynamics in T cell activation.
Rodríguez-Galán A, Dosil SG, Gómez MJ, Fernández-Delgado I, Fernández-Messina L, Sánchez-Cabo F, Sánchez-Madrid F
iScience 2021 Jun 25;24(6):102530
iScience 2021 Jun 25;24(6):102530
The molecular basis of coupling between poly(A)-tail length and translational efficiency.
Xiang K, Bartel DP
eLife 2021 Jul 2;10
eLife 2021 Jul 2;10
Identification of RNA-binding proteins that partner with Lin28a to regulate Dnmt3a expression.
Parisi S, Castaldo D, Piscitelli S, D'Ambrosio C, Divisato G, Passaro F, Avolio R, Castellucci A, Gianfico P, Masullo M, Scaloni A, Russo T
Scientific reports 2021 Jan 27;11(1):2345
Scientific reports 2021 Jan 27;11(1):2345
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, Perli SD, Conklin BR, Yamanaka S
Cell reports 2020 Jun 2;31(9):107715
Cell reports 2020 Jun 2;31(9):107715
AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2.
Yang A, Shao TJ, Bofill-De Ros X, Lian C, Villanueva P, Dai L, Gu S
Nature communications 2020 Jun 2;11(1):2765
Nature communications 2020 Jun 2;11(1):2765
A Mechanism for microRNA Arm Switching Regulated by Uridylation.
Kim H, Kim J, Yu S, Lee YY, Park J, Choi RJ, Yoon SJ, Kang SG, Kim VN
Molecular cell 2020 Jun 18;78(6):1224-1236.e5
Molecular cell 2020 Jun 18;78(6):1224-1236.e5
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E
Molecular cell 2020 Dec 3;80(5):876-891.e6
Molecular cell 2020 Dec 3;80(5):876-891.e6
3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
Yang A, Bofill-De Ros X, Shao TJ, Jiang M, Li K, Villanueva P, Dai L, Gu S
Molecular cell 2019 Aug 8;75(3):511-522.e4
Molecular cell 2019 Aug 8;75(3):511-522.e4
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Kozlowski E, Wasserman GA, Morgan M, O'Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR
PloS one 2017;12(6):e0179797
PloS one 2017;12(6):e0179797
3' Uridylation controls mature microRNA turnover during CD4 T-cell activation.
Gutiérrez-Vázquez C, Enright AJ, Rodríguez-Galán A, Pérez-García A, Collier P, Jones MR, Benes V, Mizgerd JP, Mittelbrunn M, Ramiro AR, Sánchez-Madrid F
RNA (New York, N.Y.) 2017 Jun;23(6):882-891
RNA (New York, N.Y.) 2017 Jun;23(6):882-891
TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA.
Lackey PE, Welch JD, Marzluff WF
RNA (New York, N.Y.) 2016 Nov;22(11):1673-1688
RNA (New York, N.Y.) 2016 Nov;22(11):1673-1688
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 25196-1-AP( ZCCHC6 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ZCCHC6 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ZCCHC6. This antibody recognizes human, mouse, rat antigen. The ZCCHC6 antibody has been validated for the following applications: ELISA, WB, IP analysis.
