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- References [10]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12490-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12490-1-AP, RRID:AB_10639042
- Product name
- USP3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP3 antibody (Cat. #12490-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway.
N(6)-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors.
USP3 plays a critical role in the induction of innate immune tolerance.
Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex.
Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis.
USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation.
Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners.
Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma.
A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression.
USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation.
Li A, Wang S, Nie J, Xiao S, Xie X, Zhang Y, Tong W, Yao G, Liu N, Dan F, Shu Z, Liu J, Liu Z, Yang F
Cell death & disease 2024 Mar 26;15(3):235
Cell death & disease 2024 Mar 26;15(3):235
N(6)-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors.
Gao Z, Li C, Sun H, Bian Y, Cui Z, Wang N, Wang Z, Yang Y, Liu Z, He Z, Li B, Li F, Li Z, Wang L, Zhang D, Yang L, Xu Z, Li X, Xu H
Cell death and differentiation 2023 Feb;30(2):544-559
Cell death and differentiation 2023 Feb;30(2):544-559
USP3 plays a critical role in the induction of innate immune tolerance.
Duan T, Feng Y, Du Y, Xing C, Chu J, Ou J, Liu X, Zhu M, Qian C, Yin B, Wang HY, Cui J, Wang RF
EMBO reports 2023 Dec 6;24(12):e57828
EMBO reports 2023 Dec 6;24(12):e57828
Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex.
Winden KD, Pham TT, Teaney NA, Ruiz J, Chen R, Chen C, Sahin M
Cell reports 2023 Aug 29;42(8):112838
Cell reports 2023 Aug 29;42(8):112838
Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis.
Zheng Z, Wu M, Li H, Xu W, Yang M, Pan K, Ni Y, Jiang T, Zheng H, Jin X, Zhang Y, Ding L, Fu J
BMC medicine 2023 Apr 3;21(1):132
BMC medicine 2023 Apr 3;21(1):132
USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation.
Zhuang W, Zhang L, Zheng Y, Liu B, Ma C, Zhao W, Liu S, Liu F, Gao C
Cellular & molecular immunology 2022 Oct;19(10):1141-1152
Cellular & molecular immunology 2022 Oct;19(10):1141-1152
Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners.
Zhao S, Zheng B, Wang L, Cui W, Jiang C, Li Z, Gao W, Zhang W
Chinese medical journal 2022 Nov 20;135(22):2706-2717
Chinese medical journal 2022 Nov 20;135(22):2706-2717
Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma.
Shi K, Zhang JZ, Yang L, Li NN, Yue Y, Du XH, Zhang XZ, Lu YC, Guo D
BMC cancer 2021 Nov 10;21(1):1196
BMC cancer 2021 Nov 10;21(1):1196
A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression.
Huh D, Passarelli MC, Gao J, Dusmatova SN, Goin C, Fish L, Pinzaru AM, Molina H, Ren Z, McMillan EA, Asgharian H, Goodarzi H, Tavazoie SF
The EMBO journal 2021 Jan 15;40(2):e106696
The EMBO journal 2021 Jan 15;40(2):e106696
USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation.
Wu X, Wang H, Zhu D, Chai Y, Wang J, Dai W, Xiao Y, Tang W, Li J, Hong L, Pei M, Zhang J, Lin Z, Wang J, Li A, Liu S
Cell death & disease 2021 Dec 20;13(1):10
Cell death & disease 2021 Dec 20;13(1):10
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 12490-1-AP(USP3 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP3. This antibody recognizes human, mouse antigen. The USP3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
