Antibody data

Product number
Ab104134 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant Frizzled 8 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human Frizzled 8 Antibody, Recombinant, could be used for WB and so on.Application:WB: 1/500-1/1000Protein FunctionReceptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 640-694
Epitope
HeLa and Jurkat lysates; Human endometrial carcinoma tissue.
Vial size
100_l,10_l,1ml,50_l
Concentration
1 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
FZD8 protein structure - Ab104134 shown in red.