16087-1-AP

antibody from Proteintech Group

Targeting: ACSS2 ACAS2, AceCS, ACS, ACSA, dJ1161H23.1

Provider product page for 16087-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [34]
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Product number: 16087-1-AP - Provider product page
Provider: Proteintech Group
Product name: Acetyl CoA synthetase antibody
Antibody type: Polyclonal
Description: Acetyl CoA synthetase antibody (Cat. #16087-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACSS2 protein structure - 16087-1-AP shown in red.

Submitted references Polystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism.

Huang X, Xu L, Wang J, Cheng J, Yuan J, Liu X, Larionova I, Kzhyshkowska J, Chen S, Zhao Y
Cell death discovery 2026 Mar 26;12(1)

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.

Zhang Y, Shen X, Shen Y, Wang C, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY
Nature 2026 Jan;649(8098):1022-1031

Lactylation of CREB is required for FSH-induced proliferation and differentiation of ovarian granulosa cells.

Wu G, Chen M, He T, Pan Y, Li C, Liu Z, Li H, Sheng Y, Dai W, Shen M, Liu H
Nucleic acids research 2025 Sep 5;53(17)

Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.

Liu G, Zhang H, Chen S, Gao J, Zhao H, Dong Y, Liu C, Wei X, Li T, Lu C, Zhu H, Lu D, Feng S, Li T, Zhang W, Xia Q, Man J, Zhou T, Chen J, Li A, Pan X
Cancer research 2025 Sep 15;85(18):3416-3434

Luteolin protects against alcoholic liver injury by restoring NRF2 stability to suppress ACSS2 nuclear accumulation.

Cao L, Lei Q, Dong Y, Meng C, Qi Q, Li L, Liu H, Liu X, Wang M
NPJ science of food 2025 Nov 17;9(1):234

SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.

Li W, Han J, Huang B, Xu T, Wan Y, Luo D, Kong W, Yu Y, Zhang L, Nian Y, Chu B, Yin C
The EMBO journal 2025 Mar;44(6):1641-1662

ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression.

Wang M, Wen X, Feng Z, Choubey M, Chen S, Pan R, Gong K, Tirumalasetty MB, Gao F, Liao C, Yin Z, Zhang S, He Y, Chen H, Cao Y, Miao QR, Hu W, Duan Y
Nature communications 2025 Jul 1;16(1):5491

Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.

Liu M, Xie WJ, Zhang X, Wu W, Li G, Wang L
Molecular medicine (Cambridge, Mass.) 2025 Jan 29;31(1):31

The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export.

Kim BR, Rauckhorst AJ, Chimenti MS, Rehman T, Keen HL, Karp PH, Taylor EB, Welsh MJ
Science advances 2025 Jan 24;11(4):eadr2282

IMUP promotes fatty acid metabolism and lung cancer progression by regulating TGF-β/SMAD3 signaling pathway.

Wu S, Liu F, Yao X, Lei Y, Wang W
Tissue & cell 2025 Dec;97:103061

Asiatic acid inhibits endothelial-to-mesenchymal transition in diabetic kidney disease by reducing acetyl-CoA production via targeting ACSS2.

Lin RH, Chen JC, Xu SS, Xu YY, Pan K, Wang L, Zhang J, Yin ZQ, Huang YP
Biochemical pharmacology 2025 Dec;242(Pt 2):117311

SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.

Li B, Zhou K, Yin A, Liu Y, Wang X, Cui Y, Liu F, Liu Q, Zheng H, Mu Z, Chen K, Wu Y, Chang Y, Bao J
Nature communications 2025 Dec 26;17(1):835

CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.

Hao J, Zheng J, Liu C, Lu J, Tan M, Li J, Mao J, Yu Y, Wang H, Zhang Y, Shen H
International immunopharmacology 2025 Dec 10;167:115594

Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells.

Zhang W, Yu X, Lin Y, Wu C, Zhu R, Jiang X, Tao J, Chen Z, He J, Zhang X, Xu J, Zhang M
Cellular and molecular life sciences : CMLS 2025 Apr 17;82(1):160

TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.

Zhao X, Zhang J, Xu F, Shang L, Liu Q, Shen C
Open life sciences 2024;19(1):20220957

Acetate enables metabolic fitness and cognitive performance during sleep disruption.

He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15

Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation.

Gao D, Shen Y, Xu L, Sun Y, Hu H, Xu B, Wang Z, Xu H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101158

SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.

Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129

N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.

Li X, Tang X, Xiang Y, Zhao Z, Li Y, Ding Q, Zhang L, Xu J, Zhao L, Chen Y
American journal of physiology. Gastrointestinal and liver physiology 2024 Jun 1;326(6):G697-G711

Neutrophil extracellular traps in rheumatoid arthritis: Activating fibroblast-like synoviocytes via ATP citrate lyase.

Li J, Wang X, Tan M, Zheng J, Mao J, Hao J, Shen H
International immunopharmacology 2024 Dec 25;143(Pt 3):113518

Acetic acid affects porcine oocyte metabolism and improves oocyte developmental ability.

Inoue Y, Hayashi M, Shirasuna K, Iwata H
Theriogenology 2024 Aug;224:174-182

Clostridium sporogenes increases fat accumulation in mice by enhancing energy absorption and adipogenesis.

Du L, Wang J, Qiu X, Wang Q, Peng H, Huang J, Yang F, Liu Z, Qi R
Microbiology spectrum 2024 Aug 6;12(8):e0411623

The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis.

Zhao W, Ouyang C, Zhang L, Wang J, Zhang J, Zhang Y, Huang C, Xiao Q, Jiang B, Lin F, Zhang C, Zhu M, Xie C, Huang X, Zhang B, Zhao W, He J, Chen S, Liu X, Lin D, Li Q, Wang Z
Nature communications 2024 Aug 28;15(1):7455

Sodium Acetate Enhances Neutrophil Extracellular Trap Formation via Histone Acetylation Pathway in Neutrophil-like HL-60 Cells.

Yasuda H, Takishita Y, Morita A, Tsutsumi T, Nakagawa N, Sato EF
International journal of molecular sciences 2024 Aug 11;25(16)

Proteome characterization of liver-kidney comorbidity after microbial sepsis.

Gui Y, Yu Y, Wang W, Wang Y, Lu H, Mozdzierz S, Eskander K, Lin YH, Li H, Tian XJ, Liu S, Zhou D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23597

Active post-transcriptional regulation and ACLY-mediated acetyl-CoA synthesis as a pivotal target of Shuang-Huang-Sheng-Bai formula for lung adenocarcinoma treatment.

Liu D, Dong C, Wang F, Liu W, Jin X, Qi SL, Liu L, Jin Q, Wang S, Wu J, Wang C, Yang J, Deng H, Cai Y, Yang L, Qin J, Zhang C, Yang X, Wang MS, Yu G, Xue YW, Wang Z, Ge GB, Xu Z, Chen WL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154732

Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors.

Singh KB, Hahm ER, Kim SH, Singh SV
Cancer prevention research (Philadelphia, Pa.) 2023 Jan 4;16(1):5-16

Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling.

Chen T, Yuan Z, Lei Z, Duan J, Xue J, Lu T, Yan G, Zhang L, Liu Y, Li Q, Zhang Y
Theranostics 2022;12(17):7450-7464

Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.

Zhang J, Li Q, Zhang X, Chen Y, Lu Y, Wang X, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)

Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.

Chen Y, Hao C, Chen W, Cheng W, Li P, Shen J, Tong T, Yan S, Huang S, He T, Huang Z, Meng X
Neuroscience letters 2022 Aug 10;785:136787

hsa-miR-15b-5p regulates the proliferation and apoptosis of human vascular smooth muscle cells by targeting the ACSS2/PTGS2 axis.

Gan S, Mao J, Pan Y, Tang J, Qiu Z
Experimental and therapeutic medicine 2021 Nov;22(5):1208

The SESAME complex regulates cell senescence through the generation of acetyl-CoA.

Chen W, Yu X, Wu Y, Tang J, Yu Q, Lv X, Zha Z, Hu B, Li X, Chen J, Ma L, Workman JL, Li S
Nature metabolism 2021 Jul;3(7):983-1000

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.

He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ
Molecular cell 2020 Jul 2;79(1):30-42.e4

Ferredoxin5 Deletion Affects Metabolism of Algae during the Different Phases of Sulfur Deprivation.

Subramanian V, Wecker MSA, Gerritsen A, Boehm M, Xiong W, Wachter B, Dubini A, González-Ballester D, Antonio RV, Ghirardi ML
Plant physiology 2019 Oct;181(2):426-441

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