23393-1-AP

antibody from Proteintech Group

Targeting: SCD FADS5, SCDOS

Provider product page for 23393-1-AP

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
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Product number: 23393-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#23393-1-AP, RRID:AB_2744674
Product name: SCD antibody
Antibody type: Polyclonal
Description: KD/KO validated SCD antibody (Cat. #23393-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IHC, ELISA.
Reactivity: Human, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SCD protein structure - 23393-1-AP shown in red.

Submitted references Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.

Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930

Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.

Li N, Zhu C, Fu R, Ma X, Duan Z, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287

IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD.

Han C, Hu C, Liu T, Sun Y, Hu F, He Y, Zhang J, Chen J, Ding J, Fan J, Zhang X, Wang J, Qiao X, Jiang D, Yang K, Yang S
Cell death & disease 2024 Feb 14;15(2):138

Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.

Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117

Cis-monounsaturated fatty acids inhibit ferroptosis through downregulation of transferrin receptor 1.

Shan K, Fu G, Li J, Qi Y, Feng N, Li Y, Chen YQ
Nutrition research (New York, N.Y.) 2023 Oct;118:29-40

Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation.

Wang D, Zhang M, Xu J, Yang J
Molecules (Basel, Switzerland) 2023 Mar 31;28(7)

Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer.

Lombardi S, Goldman AR, Tang HY, Kossenkov AV, Liu H, Zhou W, Herlyn M, Lin J, Zhang R
Cancer research communications 2023 Jun;3(6):1067-1077

Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-κB/NLRP3 Inflammasome Pathway.

Zhang F, Wang M, Zha Y, Zhou J, Han J, Zhang S
Nutrients 2023 Jan 1;15(1)

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.

Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638

GW9662 ameliorates nonalcoholic steatohepatitis by inhibiting the PPARγ/CD36 pathway and altering the gut microbiota.

Xiao J, Xiang H, Xiang H, Sun Z, Xu J, Ren H, Hu P, Peng M
European journal of pharmacology 2023 Dec 5;960:176113

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.

Li MT, Liu LL, Zhou Q, Huang LX, Shi YX, Hou JB, Lu HT, Yu B, Chen W, Guo ZY
Frontiers in pharmacology 2022;13:891788

Identification of icaritin derivative IC2 as an SCD-1 inhibitor with anti-breast cancer properties through induction of cell apoptosis.

Yang C, Jin YY, Mei J, Hu D, Jiao X, Che HL, Tang CL, Zhang Y, Wu GS
Cancer cell international 2022 May 31;22(1):202

Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.

Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561

Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice.

Lei SS, Zhang NY, Zhou FC, He X, Wang HY, Li LZ, Zheng X, Dong YJ, Luo R, Li B, Jin HY, Yu QX, Lv GY, Chen SH
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6689727

Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.

Hou P, Lin T, Meng S, Shi M, Chen F, Jiang T, Li Z, Li M, Chu S, Zheng J, Bai J
International journal of biological sciences 2021;17(8):1979-1994

Identification of a Novel Ferroptosis-Related Gene Prognostic Signature in Bladder Cancer.

Sun J, Yue W, You J, Wei X, Huang Y, Ling Z, Hou J
Frontiers in oncology 2021;11:730716

Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.

Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836

A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression.

Huh D, Passarelli MC, Gao J, Dusmatova SN, Goin C, Fish L, Pinzaru AM, Molina H, Ren Z, McMillan EA, Asgharian H, Goodarzi H, Tavazoie SF
The EMBO journal 2021 Jan 15;40(2):e106696

Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.

Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173

Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.

Tao L, Guo X, Xu M, Wang Y, Xie W, Chen H, Ma M, Li X
Pharmacology research & perspectives 2021 Feb;9(1):e00700

β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway.

Xu N, Luo H, Li M, Wu J, Wu X, Chen L, Gan Y, Guan F, Li M, Su Z, Chen J, Liu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Feb;134:111104

Increased lipogenesis is critical for self-renewal and growth of breast cancer stem cells: Impact of omega-3 fatty acids.

Luo H, Chen CY, Li X, Zhang X, Su CW, Liu Y, Cao T, Hao L, Wang M, Kang JX
Stem cells (Dayton, Ohio) 2021 Dec;39(12):1660-1670

Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway.

Wu Y, Yan B, Xu W, Guo L, Wang Z, Li G, Hou N, Zhang J, Ling R
International journal of biological sciences 2020;16(4):583-597

Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.

Ma SY, Sun KS, Zhang M, Zhou X, Zheng XH, Tian SY, Liu YS, Chen L, Gao X, Ye J, Zhou XM, Wang JB, Han Y
Liver international : official journal of the International Association for the Study of the Liver 2020 Oct;40(10):2427-2438

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma.

Shi X, Zheng Y, Jiang L, Zhou B, Yang W, Li L, Ding L, Huang M, Gery S, Lin DC, Koeffler HP
Nucleic acids research 2020 Nov 18;48(20):11434-11451

Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis.

Xu N, Wu X, Luo HJ, Xu FF, Huang QH, Wu JZ, Gan YX, Li MY, Lai ZQ, Lin HR, Chen JN, Su ZR, Ai WP, Liu YH
Planta medica 2020 Mar;86(4):255-266

Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice.

Freire T, Senior AM, Perks R, Pulpitel T, Clark X, Brandon AE, Wahl D, Hatchwell L, Le Couteur DG, Cooney GJ, Larance M, Simpson SJ, Solon-Biet SM
The Journal of physiology 2020 Jun;598(11):2081-2092

Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model.

Moore MC, Smith MS, Swift LL, Cincotta AH, Ezrokhi M, Cominos N, Zhang Y, Farmer B, Cherrington AD
American journal of physiology. Endocrinology and metabolism 2020 Jul 1;319(1):E133-E145

A lipid-free and insulin-supplemented medium supports De Novo fatty acid synthesis gene activation in melanoma cells.

Wu S, Näär AM
PloS one 2019;14(4):e0215022

Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma.

Yang C, Wang S, Ruan H, Li B, Cheng Z, He J, Zuo Q, Yu C, Wang H, Lv Y, Gu D, Jin G, Yao M, Qin W, Jin H
Journal of Cancer 2019;10(4):918-926

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.

Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709

Hypertensive Rats Treated Chronically With N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology.

Li B, He X, Lei SS, Zhou FC, Zhang NY, Chen YH, Wang YZ, Su J, Yu JJ, Li LZ, Zheng X, Luo R, Kołodyńska D, Xiong S, Lv GY, Chen SH
Frontiers in pharmacology 2019;10:1677

Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.

He W, Xu Y, Ren X, Xiang D, Lei K, Zhang C, Liu D
Digestive diseases and sciences 2019 Nov;64(11):3182-3191

Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.

Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, Tan N
Biochemical and biophysical research communications 2019 May 14;512(4):819-824

SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait.

Wu S, Näär AM
Scientific reports 2019 Jul 17;9(1):10369

Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.

Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2881-2889

Hepatocyte-specific deletion of Brg1 alleviates methionine-and-choline-deficient diet (MCD) induced non-alcoholic steatohepatitis in mice.

Kong M, Chen X, Xu H, Wenping, Fang M, Xu Y
Biochemical and biophysical research communications 2018 Sep 3;503(1):344-351

Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN.

Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, Zhong J, Lin S, Tong X, Su Q
Journal of experimental & clinical cancer research : CR 2018 Mar 12;37(1):54

Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.

Meng Q, Duan XP, Wang CY, Liu ZH, Sun PY, Huo XK, Sun HJ, Peng JY, Liu KX
Acta pharmacologica Sinica 2017 Jan;38(1):69-79

Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice.

Wang C, Duan X, Sun X, Liu Z, Sun P, Yang X, Sun H, Liu K, Meng Q
Food & function 2016 Sep 14;7(9):3716-23

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