Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS8162 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- DPYS polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human DPYS.
- Description
- DPYS (dihydropyrimidinase), also known as DHPase, Hydantoinase or DHP, is a 519 amino acid protein that is expressed in liver and kidney tissue and belongs to the DHOase family. Functioning as a homotetramer, DPYS uses zinc as a cofactor to catalyze the second step of reductive pyrimidine degradation, namely the conversion of 5,6-dihydrouracil to 3-ureidopropionate. DPYS is subject to post-translational carbamylation, an event which enhances the ability of DPYS to bind zinc ions. Defects in the gene encoding DPYS are the cause of DHP deficiency, an autosomal recessive disorder that is characterized by epileptic or convulsive attacks, dysmorphic features and severe developmental delay and congenital microvillous atrophy.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of DPYS polyclonal antibody