16132-1-AP

antibody from Proteintech Group

Targeting: RNASEH2A AGS4, RNASEHI, RNHIA, RNHL

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

16132-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#16132-1-AP, RRID:AB_2269729

Product name

RNASEH2A antibody

Antibody type

Polyclonal

Description

KD/KO validated RNASEH2A antibody (Cat. #16132-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.

Li Y, Shen S, Guo H, Li H, Zhang L, Zhang B, Yu XF, Wei W
Cell reports 2024 Feb 27;43(2):113749

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RTF2 controls replication repriming and ribonucleotide excision at the replisome.

Conti BA, Ruiz PD, Broton C, Blobel NJ, Kottemann MC, Sridhar S, Lach FP, Wiley T, Sasi NK, Carroll T, Smogorzewska A
bioRxiv : the preprint server for biology 2023 Mar 13;

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Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis.

Zhao F, Liu A, Gong X, Chen H, Wei J, Chen B, Chen S, Yang R, Fan Y, Mao R
Tumori 2022 Feb;108(1):63-76

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RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.

Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A
Communications biology 2022 Dec 28;5(1):1420

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Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression.

Kimura N, Takayama KI, Yamada Y, Kume H, Fujimura T, Inoue S
Cancer research communications 2022 Aug;2(8):870-883

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Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer.

Deasy SK, Uehara R, Vodnala SK, Yang HH, Dass RA, Hu Y, Lee MP, Crouch RJ, Hunter KW
PLoS genetics 2019 May;15(5):e1008020

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Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.

Uehara R, Cerritelli SM, Hasin N, Sakhuja K, London M, Iranzo J, Chon H, Grinberg A, Crouch RJ
Cell reports 2018 Oct 30;25(5):1135-1145.e5

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RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis.

Dai B, Zhang P, Zhang Y, Pan C, Meng G, Xiao X, Wu Z, Jia W, Zhang J, Zhang L
Oncology reports 2016 Jul;36(1):173-80

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human liver tissue were subjected to SDS PAGE followed by western blot with 16132-1-AP(RNASEH2A antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The RNASEH2A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RNASEH2A. This antibody recognizes human antigen. The RNASEH2A antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

16132-1-AP.pdf

Show more

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human testis using 16132-1-AP(RNASEH2A antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue