16276-1-AP

antibody from Proteintech Group

Targeting: G3BP2 KIAA0660

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

16276-1-AP

Provider

Proteintech Group

Product name

G3BP2 antibody

Antibody type

Polyclonal

Description

KD/KO validated G3BP2 antibody (Cat. #16276-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry.

Annunziato S, Quan C, Donckele EJ, Lamberto I, Bunker RD, Zlotosch M, Schwander L, Murthy A, Wiedmer L, Staehly C, Matysik M, Gilberto S, Kapsitidou D, Wible D, De Donatis GM, Trenh P, SriRamaratnam R, Strande V, Lieberherr R, Lyon D, Steiner D, Silva J, Almeida R, Dolgikh E, DeMarco B, Tsai J, Sadok A, Zarayskiy V, Walter M, Tiedt R, Lumb KJ, Bonenfant D, Fasching B, Castle JC, Townson SA, Gainza P, Petzold G
Nature structural & molecular biology 2026 Mar;33(3):479-487

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G3BP2 facilitates abnormal activation of fibroblast-like synoviocytes through p53 signaling pathway in rheumatoid arthritis.

Wu Q, Qin Y, Chen Y, Cheng N, Hu Z, Zheng Y, Wei X, Zhang W, Fang Y, Zhao Y, Zhou R, Hu W, Yao F
International immunopharmacology 2026 Jan 1;168(Pt 2):115961

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Circular RNA circMagi1 regulates the host immune response in respiratory Pseudomonas aeruginosa infection through G3BP2.

Tang M, Zhang Y, Xie R, Wu T, Sun P, Luo Y, Wang R, Ma T, Yang YY, Zhang Y, Zou C, Hu X, Li JS, Liu H, Liu Z, Zhang Q, Tang Y, Li H, Liu Y, Yang Y, Li J, Bian C, Tang Y, Zhou X
mBio 2026 Apr 8;17(4):e0361725

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Long noncoding RNA AC007637.1 inhibits tumorigenesis by regulating the Trim25/PCNA axis in colorectal cancer.

Wang X, Li J, Hao C, Cui K, Tian L, Zhao J, Li C, Feng Y, Yao S, Fei B, Mao X, Huang Z
Journal of advanced research 2026 Apr 6;

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Histone deacetylase 11 regulates stress granule formation to promote endothelial-to-mesenchymal transition in atherosclerosis.

Ren L, Liu Y, Chen D, Rong X, Wen J, Zheng Z, Chen L, He J, Wang W, Lin R
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120026

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Translation landscape of stress granules.

Wu Y, Wang X, Meng L, Liao Z, Ji W, Zhang P, Lin J, Guo Q
Science advances 2025 Oct 3;11(40):eady6859

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Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses.

Travers J, Huang E, McMullen MR, Wu J, Cajigas-Du Ross CK, Paouri E, Davalos D, Pathak V, Rotroff DM, Nagy LE
bioRxiv : the preprint server for biology 2025 May 15;

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Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis.

Tang G, Cao X, Chen J, Hui F, Xu N, Jiang Y, Lu H, Xiao H, Liang X, Ma M, Qian Y, Liu D, Wang Z, Liu S, Yu G, Sun L
Cell death & disease 2025 Jun 17;16(1):452

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The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection.

Lavender AA, Solanke O, Tang H-Y, Peck HE, Vanover D, Santangelo PJ, Brinton MA
Journal of virology 2025 Jul 22;99(7):e0079425

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Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition.

Yang W, Cong S, Li R, Schwarz J, Schulze T, Gevelhoff RA, Chen X, Ullrich S, Falkenstein K, Ott D, Eixmann P, Trentino A, Thien A, Heidmann T, Schulze E, Warscheid B, Baumeister R, Qi W
Nature communications 2025 Jul 11;16(1):6327

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Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity.

Ru S, Tang S, Xu H, Yin J, Guo Y, Song L, Jin Z, Lee D, Chan YH, Chen X, Buerer L, Fairbrother W, Jia W, Casanova JL, Zhang SY, Gao D
The Journal of experimental medicine 2025 Jan 6;222(1)

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N-6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5' splice site motifs.

Lee ES, Smith HW, Wang YE, Ihn SS, Scalize de Oliveira L, Kejiou NS, Liang YL, Nabeel-Shah S, Jomphe RY, Pu S, Greenblatt JF, Palazzo AF
Life science alliance 2025 Feb;8(2)

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Perillaldehyde Improves Parkinson-Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models.

Fang M, Luo L, Chen Y, Liu Y, Yan Y, Wang F, Zou Y, Zhu H, Wu X, Jin Z, Huang C, Zhang Y, Fan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2412152

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TIA1-Mediated Stress Granules Promote the Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis through Upregulating IL-31RA Signaling.

Hua X, Jin L, Fang Z, Weng Y, Zhang Y, Zhang J, Xie D, Tang Y, Guo S, Huang Y, Dai Y, Li J, Huang Z, Zhang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409086

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Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.

Fan B, Li Y, Wang Y, Yang S, Peng Q, Qian J, Wang C, Zhang X, Xu H, Liu S, He W, Zhang G, Zhu X, Li Y, Zhao Y, Hu M, Wang W, Zhou J, Guo R, He K, Li B
Nucleic acids research 2024 Nov 27;52(21):13174-13191

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TRIM25 predominately associates with anti-viral stress granules.

Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau DD, Yang P, Zhang L, Zhou F, Bai P, Jia D
Nature communications 2024 May 15;15(1):4127

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Mammalian IRE1α dynamically and functionally coalesces with stress granules.

Liu S, Zhang X, Yao X, Wang G, Huang S, Chen P, Tang M, Cai J, Wu Z, Zhang Y, Xu R, Liu K, He K, Wang Y, Jiang L, Wang QA, Rui L, Liu J, Liu Y
Nature cell biology 2024 Jun;26(6):917-931

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Peptide Transporter 1-Mediated Dipeptide Transport Promotes Hepatocellular Carcinoma Metastasis by Activating MAP4K4/G3BP2 Signaling Axis.

Song F, Zhang Z, Liu W, Xu T, Hu X, Wang Q, Zhang W, Ge L, Zhang C, Hu Q, Qin H, Zhang S, Ren X, Fan W, Zhang Y, Huang P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2306671

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Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1.

Zhan W, Li Z, Zhang J, Liu Y, Liu G, Li B, Shen R, Jiang Y, Shang W, Gao S, Wu H, Wang Y, Chen W, Wang Z
The EMBO journal 2024 Jul;43(13):2759-2788

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Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer.

Li Y, Xu C, Qian X, Wang G, Han C, Hua H, Dong M, Chen J, Yu H, Zhang R, Feng X, Yang Z, Pan Y
Cell death discovery 2024 Jul 30;10(1):344

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hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.

Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769

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Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis.

Li Z, Luo L, Ju X, Huang S, Lei L, Yu Y, Liu J, Zhang P, Chi T, Ma P, Huang C, Huang X, Ding Q, Zhang Y
The EMBO journal 2024 Dec;43(24):6444-6468

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Stress granules play a critical role in hexavalent chromium-induced malignancy in a G3BP1 dependent manner.

Shaw B, Thwin PH, Jia N, Weng H, Ma C, Zhu H, Wang L
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124997

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The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network.

Yao Z, Liu Y, Chen Q, Chen X, Zhu Z, Song S, Ma X, Yang P
Cell reports 2024 Aug 27;43(8):114617

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Stress granules plug and stabilize damaged endolysosomal membranes.

Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG
Nature 2023 Nov;623(7989):1062-1069

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USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.

Wang N, Li T, Liu W, Lin J, Zhang K, Li Z, Huang Y, Shi Y, Xu M, Liu X
Cell death & disease 2023 Mar 6;14(3):182

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Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling.

Kejiou NS, Ilan L, Aigner S, Luo E, Tonn T, Ozadam H, Lee M, Cole GB, Rabano I, Rajakulendran N, Yee BA, Najafabadi HS, Moraes TF, Angers S, Yeo GW, Cenik C, Palazzo AF
Nucleic acids research 2023 Jul 7;51(12):6461-6478

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TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.

Kitajima H, Maruyama R, Niinuma T, Yamamoto E, Takasawa A, Takasawa K, Ishiguro K, Tsuyada A, Suzuki R, Sudo G, Kubo T, Mitsuhashi K, Idogawa M, Tange S, Toyota M, Yoshido A, Kumegawa K, Kai M, Yanagihara K, Tokino T, Osanai M, Nakase H, Suzuki H
Cell death & disease 2023 Jul 13;14(7):424

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DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling.

Zhang K, Huang M, Li A, Wen J, Yan L, Li Y, Guo L, Senthil KS, Zhou Y, Chen G, Liu Y, Zhang X, Yao X, Qin D, Su H
Cell reports 2023 Jan 31;42(1):111986

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Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.

Cui Q, Bi H, Lv Z, Wu Q, Hua J, Gu B, Huo C, Tang M, Chen Y, Chen C, Chen S, Zhang X, Wu Z, Lao Z, Sheng N, Shen C, Zhang Y, Wu ZY, Jin Z, Yang P, Liu H, Li J, Bai G
Cell 2023 Feb 16;186(4):803-820.e25

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HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.

Liu B, Zhang J, Meng X, Xie SM, Liu F, Chen H, Yao D, Li M, Guo M, Shen H, Zhang X, Xing L
Oncogene 2023 Apr;42(15):1181-1195

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Identification of a non-canonical G3BP-binding sequence in a Mayaro virus nsP3 hypervariable domain.

Neyret A, Bernard E, Aïqui-Reboul-Paviet O, Bakhache W, Eldin P, Chaloin L, Briant L
Frontiers in cellular and infection microbiology 2022;12:958176

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G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice.

Yun D, Zhou L, Shi J, Li X, Wu X, Sun F
PeerJ 2022;10:e13532

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RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2.

Chen Y, Zhou S, Wan K, Yu L, Zhao C, Deng H, Ou Q, Qin J, Hu J, Hou Z
Oncogene 2022 Jun;41(25):3433-3444

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SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

Liu H, Bai Y, Zhang X, Gao T, Liu Y, Li E, Wang X, Cao Z, Zhu L, Dong Q, Hu Y, Wang G, Song C, Niu X, Zheng T, Wang D, Liu Z, Jin Y, Li P, Bian X, Cao C, Liu X
Journal of virology 2022 Jun 22;96(12):e0041222

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BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.

Zhang H, Wang Y, Zhang W, Wu Q, Fan J, Zhan Q
Cancer communications (London, England) 2021 Mar;41(3):240-257

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G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.

Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28

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Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis.

Liu H, Bi J, Dong W, Yang M, Shi J, Jiang N, Lin T, Huang J
Molecular cancer 2018 Nov 20;17(1):161