DPABH-25989

antibody from Creative Diagnostics

Targeting: EIF3E eIF3-p48, EIF3S6, INT6

No application information provided.

Antibody Data

Product number

DPABH-25989

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-25989, RRID:AB_2516523

Product name

Rabbit Anti-Human EIF3E Polyclonal Antibody

Antibody type

Polyclonal

Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD)