MA1-7631

antibody from Invitrogen Antibodies

Targeting: CD4

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

MA1-7631

Provider

Invitrogen Antibodies

Product name

CD4 Monoclonal Antibody (RIV6)

Antibody type

Monoclonal

Antigen

Purifed from natural sources

Description

MA1-7631 detects CD4 from human, rat and mouse samples.

Antibody clone number

RIV6

Concentration

1 mg/mL

References

Submitted references

T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease.

Williams GP, Marmion DJ, Schonhoff AM, Jurkuvenaite A, Won WJ, Standaert DG, Kordower JH, Harms AS
Acta neuropathologica 2020 May;139(5):855-874

---

Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson's Disease.

Chandra G, Roy A, Rangasamy SB, Pahan K
Journal of immunology (Baltimore, Md. : 1950) 2017 Jun 1;198(11):4312-4326

---

In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis.

Chang A, Henderson SG, Brandt D, Liu N, Guttikonda R, Hsieh C, Kaverina N, Utset TO, Meehan SM, Quigg RJ, Meffre E, Clark MR
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 1;186(3):1849-60

---

Memory B-cell aggregates in skin biopsy are diagnostic for primary Sjögren's syndrome.

Roguedas AM, Pers JO, Lemasson G, Devauchelle V, Tobón GJ, Saraux A, Misery L, Youinou P
Journal of autoimmunity 2010 Nov;35(3):241-7

---

Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients.

Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C, Li SP, Zheng L
Journal of hepatology 2009 May;50(5):980-9

---

Histopathological features in both the eschar and erythematous lesions of Tsutsugamushi Disease: identification of CD30+ cell infiltration in Tsutsugamushi disease.

Lee JS, Park MY, Kim YJ, Kil HI, Choi YH, Kim YC
The American Journal of dermatopathology 2009 Aug;31(6):551-6

---

BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome.

Pers JO, Devauchelle V, Daridon C, Bendaoud B, Le Berre R, Bordron A, Hutin P, Renaudineau Y, Dueymes M, Loisel S, Berthou C, Saraux A, Youinou P
Arthritis and rheumatism 2007 May;56(5):1464-77

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

NULL

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Fig. 2 T cell infiltration in human postmortem MSA brain tissue. Control (left) and MSA (middle, right) postmortem brain sections of the putamen (top panel) and substantia nigra (bottom panel) were stained with CD3 ( a ), CD4 ( b ), and CD8 ( c ) antibodies (DAB, black staining). Unbiased stereological cell counts indicate a significant increase in the number of CD3 + T cells ( a ), CD4 + T ( b ), and CD8 + T cells ( c ) in the putamen and in the substantia nigra of MSA cases compared to control subjects. Brown coloring in the nigral sections are neuromalanin laden dopamine neurons (arrowheads). Of note, the yellow-brown pigment in putamenal sections is lipofuscin, an aging pigment composed of lipid residues of lysosomal digestion. Arrows denote T cells; arrowheads denote neuromelanin laden dopamine neurons in the substantia nigra. Representative images. All scale bars indicate 25 mum. Graphs display the mean +- SEM. * p < 0.05, ** p < 0.01, unpaired nonparametric Mann Whitney Test was used to compare groups, n = 5 per group