Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Flow cytometry [2]
- Other assay [2]
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- Product number
- Q10008 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD4 Monoclonal Antibody (S3.5), Qdot™ 605
- Antibody type
- Monoclonal
- Antigen
- Other
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- S3.5
- Vial size
- 100 µL
- Storage
- 4° C
Submitted references A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients.
CARD8 inflammasome activation triggers pyroptosis in human T cells.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4(+) T cells from ART-suppressed individuals.
Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4(+) T Cells.
PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis.
Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction.
Early-onset childhood atopic dermatitis is related to NLRP2 repression.
Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population.
HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis-Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection.
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
Analysis of Intracellular Ca(2+) Mobilization in Human NK Cell Subsets by Flow Cytometry.
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.
Antiviral Innate Immune Activation in HIV-Infected Adults Negatively Affects H1/IC31-Induced Vaccine-Specific Memory CD4+ T Cells.
Qualification of a whole blood intracellular cytokine staining assay to measure mycobacteria-specific CD4 and CD8 T cell immunity by flow cytometry.
Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.
The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses.
Distinct T-cell responses when BCG vaccination is delayed from birth to 6 weeks of age in Ugandan infants.
Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.
Differential regulatory T cell activity in HIV type 1-exposed seronegative individuals.
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.
Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.
Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners.
The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope.
Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load.
Li C, Phoon YP, Karlinsey K, Tian YF, Thapaliya S, Thongkum A, Qu L, Matz AJ, Cameron M, Cameron C, Menoret A, Funchain P, Song JM, Diaz-Montero CM, Tamilselvan B, Golden JB, Cartwright M, Rodriguez A, Bonin C, Vella A, Zhou B, Gastman BR
The Journal of experimental medicine 2022 Jan 3;219(1)
The Journal of experimental medicine 2022 Jan 3;219(1)
CARD8 inflammasome activation triggers pyroptosis in human T cells.
Linder A, Bauernfried S, Cheng Y, Albanese M, Jung C, Keppler OT, Hornung V
The EMBO journal 2020 Oct 1;39(19):e105071
The EMBO journal 2020 Oct 1;39(19):e105071
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4(+) T cells from ART-suppressed individuals.
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ, Lewin SR, Routy JP, Sékaly RP, Chomont N
Nature communications 2019 Feb 18;10(1):814
Nature communications 2019 Feb 18;10(1):814
Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4(+) T Cells.
Kulpa DA, Talla A, Brehm JH, Ribeiro SP, Yuan S, Bebin-Blackwell AG, Miller M, Barnard R, Deeks SG, Hazuda D, Chomont N, Sékaly RP
Journal of virology 2019 Dec 15;93(24)
Journal of virology 2019 Dec 15;93(24)
PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis.
Day CL, Abrahams DA, Bunjun R, Stone L, de Kock M, Walzl G, Wilkinson RJ, Burgers WA, Hanekom WA
Frontiers in immunology 2018;9:1995
Frontiers in immunology 2018;9:1995
Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction.
Younes SA, Talla A, Pereira Ribeiro S, Saidakova EV, Korolevskaya LB, Shmagel KV, Shive CL, Freeman ML, Panigrahi S, Zweig S, Balderas R, Margolis L, Douek DC, Anthony DD, Pandiyan P, Cameron M, Sieg SF, Calabrese LH, Rodriguez B, Lederman MM
The Journal of clinical investigation 2018 Nov 1;128(11):5083-5094
The Journal of clinical investigation 2018 Nov 1;128(11):5083-5094
Early-onset childhood atopic dermatitis is related to NLRP2 repression.
Thürmann L, Grützmann K, Klös M, Bieg M, Winter M, Polte T, Bauer T, Schick M, Bewerunge-Hudler M, Röder S, Bauer M, Wissenbach DK, Sack U, Weichenhan D, Mücke O, Plass C, Borte M, von Bergen M, Lehmann I, Eils R, Trump S
The Journal of allergy and clinical immunology 2018 Apr;141(4):1482-1485.e16
The Journal of allergy and clinical immunology 2018 Apr;141(4):1482-1485.e16
Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population.
Baguma R, Penn-Nicholson A, Smit E, Erasmus M, Day J, Makhethe L, de Kock M, Hughes EJ, van Rooyen M, Pienaar B, Stone L, Hanekom W, Brennan MJ, Wallis RS, Hatherill M, Scriba TJ
PloS one 2017;12(9):e0184563
PloS one 2017;12(9):e0184563
HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis-Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection.
Day CL, Abrahams DA, Harris LD, van Rooyen M, Stone L, de Kock M, Hanekom WA
Journal of immunology (Baltimore, Md. : 1950) 2017 Sep 15;199(6):2069-2080
Journal of immunology (Baltimore, Md. : 1950) 2017 Sep 15;199(6):2069-2080
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
Gavegnano C, Brehm JH, Dupuy FP, Talla A, Ribeiro SP, Kulpa DA, Cameron C, Santos S, Hurwitz SJ, Marconi VC, Routy JP, Sabbagh L, Schinazi RF, Sékaly RP
PLoS pathogens 2017 Dec;13(12):e1006740
PLoS pathogens 2017 Dec;13(12):e1006740
Analysis of Intracellular Ca(2+) Mobilization in Human NK Cell Subsets by Flow Cytometry.
Theorell J, Bryceson YT
Methods in molecular biology (Clifton, N.J.) 2016;1441:117-30
Methods in molecular biology (Clifton, N.J.) 2016;1441:117-30
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast AJ, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg CB, Walker BD, Ndung'u T, Jooste P, Moore PL, Morris L, Goulder P
Science translational medicine 2016 Sep 28;8(358):358ra125
Science translational medicine 2016 Sep 28;8(358):358ra125
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.
Fromentin R, Bakeman W, Lawani MB, Khoury G, Hartogensis W, DaFonseca S, Killian M, Epling L, Hoh R, Sinclair E, Hecht FM, Bacchetti P, Deeks SG, Lewin SR, Sékaly RP, Chomont N
PLoS pathogens 2016 Jul;12(7):e1005761
PLoS pathogens 2016 Jul;12(7):e1005761
Antiviral Innate Immune Activation in HIV-Infected Adults Negatively Affects H1/IC31-Induced Vaccine-Specific Memory CD4+ T Cells.
Lenz N, Schindler T, Kagina BM, Zhang JD, Lukindo T, Mpina M, Bang P, Kromann I, Hoff ST, Andersen P, Reither K, Churchyard GJ, Certa U, Daubenberger CA
Clinical and vaccine immunology : CVI 2015 Jul;22(7):688-96
Clinical and vaccine immunology : CVI 2015 Jul;22(7):688-96
Qualification of a whole blood intracellular cytokine staining assay to measure mycobacteria-specific CD4 and CD8 T cell immunity by flow cytometry.
Kagina BM, Mansoor N, Kpamegan EP, Penn-Nicholson A, Nemes E, Smit E, Gelderbloem S, Soares AP, Abel B, Keyser A, Sidibana M, Hughes JE, Kaplan G, Hussey GD, Hanekom WA, Scriba TJ
Journal of immunological methods 2015 Feb;417:22-33
Journal of immunological methods 2015 Feb;417:22-33
Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.
Bending D, Pesenacker AM, Ursu S, Wu Q, Lom H, Thirugnanabalan B, Wedderburn LR
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2699-708
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2699-708
The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses.
Kagina BM, Tameris MD, Geldenhuys H, Hatherill M, Abel B, Hussey GD, Scriba TJ, Mahomed H, Sadoff JC, Hanekom WA, 018-402 Clinical Lab study team, Mansoor N, Hughes J, de Kock M, Whatney W, Africa H, Krohn C, Veldsman A, Kany AL, Douoguih M, Pau MG, Hendriks J, McClainc B, Benko J, Snowden MA, Hokey DA
Vaccine 2014 Oct 14;32(45):5908-17
Vaccine 2014 Oct 14;32(45):5908-17
Distinct T-cell responses when BCG vaccination is delayed from birth to 6 weeks of age in Ugandan infants.
Lutwama F, Kagina BM, Wajja A, Waiswa F, Mansoor N, Kirimunda S, Hughes EJ, Kiwanuka N, Joloba ML, Musoke P, Scriba TJ, Mayanja-Kizza H, Day CL, Hanekom WA
The Journal of infectious diseases 2014 Mar;209(6):887-97
The Journal of infectious diseases 2014 Mar;209(6):887-97
Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.
Dintwe OB, Day CL, Smit E, Nemes E, Gray C, Tameris M, McShane H, Mahomed H, Hanekom WA, Scriba TJ
European journal of immunology 2013 Sep;43(9):2409-20
European journal of immunology 2013 Sep;43(9):2409-20
Differential regulatory T cell activity in HIV type 1-exposed seronegative individuals.
Pattacini L, Murnane PM, Kahle EM, Bolton MJ, Delrow JJ, Lingappa JR, Katabira E, Donnell D, McElrath MJ, Baeten JM, Lund JM
AIDS research and human retroviruses 2013 Oct;29(10):1321-9
AIDS research and human retroviruses 2013 Oct;29(10):1321-9
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.
Paich HA, Sheridan PA, Handy J, Karlsson EA, Schultz-Cherry S, Hudgens MG, Noah TL, Weir SS, Beck MA
Obesity (Silver Spring, Md.) 2013 Nov;21(11):2377-86
Obesity (Silver Spring, Md.) 2013 Nov;21(11):2377-86
Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.
Introini A, Vanpouille C, Lisco A, Grivel JC, Margolis L
PLoS pathogens 2013 Feb;9(2):e1003148
PLoS pathogens 2013 Feb;9(2):e1003148
Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners.
Pala P, Serwanga J, Watera C, Ritchie AJ, Moodie Z, Wang M, Goonetilleke N, Birabwa E, Hughes P, Senkaali D, Nakiboneka R, Grosskurth H, Haynes B, McMichael A, Kaleebu P, Center for HIV/AIDS Vaccine Immunology
Journal of virology 2013 Aug;87(16):9053-63
Journal of virology 2013 Aug;87(16):9053-63
The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope.
de Souza MS, Ratto-Kim S, Chuenarom W, Schuetz A, Chantakulkij S, Nuntapinit B, Valencia-Micolta A, Thelian D, Nitayaphan S, Pitisuttithum P, Paris RM, Kaewkungwal J, Michael NL, Rerks-Ngarm S, Mathieson B, Marovich M, Currier JR, Kim JH, Ministry of Public Health–Thai AIDS Vaccine Evaluation Group Collaborators
Journal of immunology (Baltimore, Md. : 1950) 2012 May 15;188(10):5166-76
Journal of immunology (Baltimore, Md. : 1950) 2012 May 15;188(10):5166-76
Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load.
Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, O'rie T, Pienaar B, de Kock M, Kaplan G, Mahomed H, Dheda K, Hanekom WA
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2222-32
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2222-32
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Qdot® 605 anti-human CD4 conjugate 605/20 band pass filter
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Qdot® 605 anti-human CD4 conjugate 605/20 band pass filter
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 1 Dipeptidyl-peptidase inhibition triggers a lytic cell death in primary human T cells A-C FACS -sorted T-cell populations and Monocyte-derived Macrophages were treated with the indicated stimuli: Nigericin (Nig. 4 h), NeedleTox (4 h), Val-boroPro (VbP 22 h), and ABT 737/S63845 (A/S 22 h). When indicated, cells were primed with LPS for 2 h prior to stimulation. When indicated, MCC 950 was added to the media 30 min prior to the addition of Nigericin. LDH activity (A) and IL -1beta and IL -18 concentration (B and C, respectively) in the supernatant were determined by LDH cytotoxicity assay and ELISA , respectively. Individual data points +- SEM from three independent donors are shown. Statistics indicate significance by two-way ANOVA : *** P
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure EV4 Polyclonal and clonal gene targeting approaches uncover a functional CARD 8 inflammasome in T cells A MiSeq analysis of polyclonal CD4 T cells targeted either with CARD8 gRNA1, CARD8 gRNA2, or the combination of both. B Immunoblot of VbP-treated CD4 T cells targeted with gRNAs against the indicated genes. Two gRNAs/target gene were used. 14 days after editing and expansion, cells were treated for 18 h with VbP. C Clonal knockout T-cell pools of the indicated genotype were treated with VbP and morphologic changes as well as PI uptake were monitored by live-cell imaging microscopy using a 25x objective. Fraction of PI-pos. cells over time are shown. Images were acquired every 2 min. Background PI-levels from the start of the experiment were subtracted. Data were normalized by a sliding window covering 30 min. Data (mean +- SEM) from three independent experiments using the same clonal knockout T-cell pool from one donor are shown. On the right, representative images for each genotype at 8 h of VbP treatment are shown. Scale bars: 50 mum.