Antibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10720-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10720-1-AP, RRID:AB_2237516
- Product name
- Cyclophilin A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cyclophilin A antibody (Cat. #10720-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Construction and validation of a prognostic signature based on necroptosis-related genes in hepatocellular carcinoma.
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.
Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.
Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway.
Identification and validation of necroptosis-related prognostic gene signature and tumor immune microenvironment infiltration characterization in esophageal carcinoma.
Intron retention is a stress response in sensor genes and is restored by Japanese herbal medicines: A basis for future clinical applications.
Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.
Cyclophilin A binds to AKT1 and facilitates the tumorigenicity of Epstein-Barr virus by mediating the activation of AKT/mTOR/NF-κB positive feedback loop.
Tacrolimus ameliorates podocyte injury by restoring FK506 binding protein 12 (FKBP12) at actin cytoskeleton.
CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis.
Cyclophilin A inhibits trophoblast migration and invasion in vitro and vivo through p38/ERK/JNK pathways and causes features of preeclampsia in mice.
Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome.
Exosomal cyclophilin A as a novel noninvasive biomarker for Epstein-Barr virus associated nasopharyngeal carcinoma.
Overexpression of Cyclophilin A in Human Periapical Lesions.
Correlation of five secretory proteins with the nasopharyngeal carcinoma metastasis and the clinical applications.
Downregulation of Peptidylprolyl isomerase A promotes cell death and enhances doxorubicin-induced apoptosis in hepatocellular carcinoma.
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma.
Proteomic methods reveal cyclophilin A function as a host restriction factor against rotavirus infection.
Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis.
Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma.
Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue.
CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.
Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection.
Proteomic analysis of low dose arsenic and ionizing radiation exposure on keratinocytes.
Proteomic analysis of hepatitis B surface antigen positive transgenic mouse liver and decrease of cyclophilin A.
Layish B, Goli R, Flick H, Huang SW, Zhang RZ, Kvaratskhelia M, Kane M
PLoS pathogens 2024 Mar;20(3):e1011830
PLoS pathogens 2024 Mar;20(3):e1011830
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573
Cancer gene therapy 2024 Apr;31(4):562-573
Construction and validation of a prognostic signature based on necroptosis-related genes in hepatocellular carcinoma.
Peng YL, Wang LX, Li MY, Liu LP, Li RS
PloS one 2023;18(2):e0279744
PloS one 2023;18(2):e0279744
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.
Kanwore K, Kanwore K, Guo X, Xia Y, Zhou H, Zhang L, Adzika GK, Joseph AA, Abiola AA, Mu P, Kambey PA, Noah MLN, Gao D
Inflammation and regeneration 2023 Oct 13;43(1):49
Inflammation and regeneration 2023 Oct 13;43(1):49
Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.
Layish B, Goli R, Flick H, Huang SW, Zhang RZ, Kvaratskhelia M, Kane M
bioRxiv : the preprint server for biology 2023 Nov 17;
bioRxiv : the preprint server for biology 2023 Nov 17;
Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
Adamson SE, Li ZA, Hughes JW
Islets 2023 Dec 31;15(1):2252855
Islets 2023 Dec 31;15(1):2252855
Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway.
Huang H, Jin K, Ouyang K, Jiang Z, Yang Z, Hu N, Dai Y, Zhang Y, Zhang Q, Han Y, Zhao J, Lin H, Wang C, Wang C, Sun X, Lu D, Zhu J, Li J
Frontiers in microbiology 2022;13:1046176
Frontiers in microbiology 2022;13:1046176
Identification and validation of necroptosis-related prognostic gene signature and tumor immune microenvironment infiltration characterization in esophageal carcinoma.
Sun K, Hong JJ, Chen DM, Luo ZX, Li JZ
BMC gastroenterology 2022 Jul 15;22(1):344
BMC gastroenterology 2022 Jul 15;22(1):344
Intron retention is a stress response in sensor genes and is restored by Japanese herbal medicines: A basis for future clinical applications.
Vu TD, Ito N, Oshima K, Maruko A, Nishi A, Mizoguchi K, Odaguchi H, Kobayashi Y, Okada N
Gene 2022 Jul 1;830:146496
Gene 2022 Jul 1;830:146496
Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.
Zhang S, Huang W, Ren L, Ju X, Gong M, Rao J, Sun L, Li P, Ding Q, Wang J, Zhang QC
Cell research 2022 Jan;32(1):9-23
Cell research 2022 Jan;32(1):9-23
Cyclophilin A binds to AKT1 and facilitates the tumorigenicity of Epstein-Barr virus by mediating the activation of AKT/mTOR/NF-κB positive feedback loop.
Xin S, Liu L, Li Y, Yang J, Zuo L, Cao P, Yan Q, Li S, Yang L, Cui T, Lu J
Virologica Sinica 2022 Dec;37(6):913-921
Virologica Sinica 2022 Dec;37(6):913-921
Tacrolimus ameliorates podocyte injury by restoring FK506 binding protein 12 (FKBP12) at actin cytoskeleton.
Yasuda H, Fukusumi Y, Ivanov V, Zhang Y, Kawachi H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21983
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21983
CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.
Asamitsu S, Yabuki Y, Ikenoshita S, Kawakubo K, Kawasaki M, Usuki S, Nakayama Y, Adachi K, Kugoh H, Ishii K, Matsuura T, Nanba E, Sugiyama H, Fukunaga K, Shioda N
Science advances 2021 Jan;7(3)
Science advances 2021 Jan;7(3)
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Pasetto L, Grassano M, Pozzi S, Luotti S, Sammali E, Migazzi A, Basso M, Spagnolli G, Biasini E, Micotti E, Cerovic M, Carli M, Forloni G, De Marco G, Manera U, Moglia C, Mora G, Traynor BJ, Chiò A, Calvo A, Bonetto V
Brain : a journal of neurology 2021 Dec 31;144(12):3710-3726
Brain : a journal of neurology 2021 Dec 31;144(12):3710-3726
Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis.
Pasetto L, Callegaro S, Corbelli A, Fiordaliso F, Ferrara D, Brunelli L, Sestito G, Pastorelli R, Bianchi E, Cretich M, Chiari M, Potrich C, Moglia C, Corbo M, Sorarù G, Lunetta C, Calvo A, Chiò A, Mora G, Pennuto M, Quattrone A, Rinaldi F, D'Agostino VG, Basso M, Bonetto V
Molecular neurodegeneration 2021 Aug 10;16(1):52
Molecular neurodegeneration 2021 Aug 10;16(1):52
Cyclophilin A inhibits trophoblast migration and invasion in vitro and vivo through p38/ERK/JNK pathways and causes features of preeclampsia in mice.
Hu H, Jiang J, Chen Q, Wei S, Liu M, Chen X, Fan C, Ma J, Chen W, Wang X, Zhong M
Life sciences 2020 Nov 15;261:118351
Life sciences 2020 Nov 15;261:118351
Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome.
Xin S, Du S, Liu L, Xie Y, Zuo L, Yang J, Hu J, Yue W, Zhang J, Cao P, Zhu F, Lu J
Frontiers in microbiology 2019;10:2879
Frontiers in microbiology 2019;10:2879
Exosomal cyclophilin A as a novel noninvasive biomarker for Epstein-Barr virus associated nasopharyngeal carcinoma.
Liu L, Zuo L, Yang J, Xin S, Zhang J, Zhou J, Li G, Tang J, Lu J
Cancer medicine 2019 Jun;8(6):3142-3151
Cancer medicine 2019 Jun;8(6):3142-3151
Overexpression of Cyclophilin A in Human Periapical Lesions.
Wang Y, Liu G, Zhang J, Zhu L, Yu J, Zhu S, Lv F, Peng B
Journal of endodontics 2019 Dec;45(12):1496-1503
Journal of endodontics 2019 Dec;45(12):1496-1503
Correlation of five secretory proteins with the nasopharyngeal carcinoma metastasis and the clinical applications.
Tao Y, Wang K, Chen Z, Long L, Wu Q, Cui F, Zhu L, Xiang M, Jiang Y, Liang Y, Qiu S, Xiao Z, Yi B
Oncotarget 2017 Apr 25;8(17):29383-29394
Oncotarget 2017 Apr 25;8(17):29383-29394
Downregulation of Peptidylprolyl isomerase A promotes cell death and enhances doxorubicin-induced apoptosis in hepatocellular carcinoma.
Cheng S, Luo M, Ding C, Peng C, Lv Z, Tong R, Xiao H, Xie H, Zhou L, Wu J, Zheng S
Gene 2016 Oct 10;591(1):236-244
Gene 2016 Oct 10;591(1):236-244
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma.
Huang CF, Zhang L, Ma SR, Zhao ZL, Wang WM, He KF, Zhao YF, Zhang WF, Liu B, Sun ZJ
PloS one 2013;8(12):e83479
PloS one 2013;8(12):e83479
Proteomic methods reveal cyclophilin A function as a host restriction factor against rotavirus infection.
He H, Mou Z, Li W, Fei L, Tang Y, Zhang J, Yan P, Chen Z, Yang X, Shen Z, Li J, Wu Y
Proteomics 2013 Apr;13(7):1121-32
Proteomics 2013 Apr;13(7):1121-32
Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis.
Nishioku T, Dohgu S, Koga M, Machida T, Watanabe T, Miura T, Tsumagari K, Terasawa M, Yamauchi A, Kataoka Y
Journal of inflammation (London, England) 2012 Nov 20;9(1):44
Journal of inflammation (London, England) 2012 Nov 20;9(1):44
Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma.
Huang C, Sun Z, Sun Y, Chen X, Zhu X, Fan C, Liu B, Zhao Y, Zhang W
Histopathology 2012 Apr;60(5):793-803
Histopathology 2012 Apr;60(5):793-803
Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue.
Huang CF, Sun ZJ, Zhao YF, Chen XM, Jia J, Zhang WF
Oral diseases 2011 Apr;17(3):328-34
Oral diseases 2011 Apr;17(3):328-34
CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.
Watanabe A, Yoneda M, Ikeda F, Terao-Muto Y, Sato H, Kai C
Journal of virology 2010 May;84(9):4183-93
Journal of virology 2010 May;84(9):4183-93
Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection.
Tian X, Zhao C, Zhu H, She W, Zhang J, Liu J, Li L, Zheng S, Wen YM, Xie Y
Journal of virology 2010 Apr;84(7):3373-81
Journal of virology 2010 Apr;84(7):3373-81
Proteomic analysis of low dose arsenic and ionizing radiation exposure on keratinocytes.
Berglund SR, Santana AR, Li D, Rice RH, Rocke DM, Goldberg Z
Proteomics 2009 Apr;9(7):1925-38
Proteomics 2009 Apr;9(7):1925-38
Proteomic analysis of hepatitis B surface antigen positive transgenic mouse liver and decrease of cyclophilin A.
Zhao C, Fang CY, Tian XC, Wang L, Yang PY, Wen YM
Journal of medical virology 2007 Oct;79(10):1478-84
Journal of medical virology 2007 Oct;79(10):1478-84
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10720-1-AP(CYPA antibody) at dilution of 1:1500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using PPIA antibody 10720-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10720-1-AP(CYPA antibody) at dilution of 1:200 (under 10x lens)
- Sample type
- tissue