10720-1-AP

antibody from Proteintech Group

Targeting: PPIA CYPA

Provider product page for 10720-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [42]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 10720-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10720-1-AP, RRID:AB_2237516
Product name: Cyclophilin A antibody
Antibody type: Polyclonal
Description: KD/KO validated Cyclophilin A antibody (Cat. #10720-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PPIA protein structure - 10720-1-AP shown in red.

Submitted references Cyclophilin A stabilizes the capsid protein p72 to facilitate African swine fever virus replication.

Kong H, Yang L, Zhang Z, Zhang Y, Liu L, Wang W, Song L, Zhu Y, Sun E, Li F, Bu Z, Sheng X, Zhao D
Nature communications 2026 Mar 7;17(1)

Multi-omics reveals cholesterol-driven macrophage metabolic reprogramming and inflammation in chronic obstructive pulmonary disease.

Ran X, Yang Z, Cheng L, Li W, Cui J, Huang P, Wang Z, Mao Z, Yi E, Tian Y, Li P, Zhou Y, Ran P, Guo F
Genome medicine 2026 Jan 5;18(1):17

‌PPIA regulates fatty acid and glutamine metabolism in lung adenocarcinoma based on multiomics prognostic model and experiment validation.

Gan Y, Wei W, Jiang B, Zhang X, Jiang L, Teng L, Xie X, Liu Y, Xie Q, Jiang L
Scientific reports 2026 Jan 5;16(1):4154

Spinal Cord Phosphoproteome of SCA2 Mouse Model Reveals Alteration of ATXN2-N-Term PRM-SH3-Actin Interactome and of Autophagy.

Almaguer-Mederos LE, Kandi AR, Sen NE, Canet-Pons J, Berger LM, Stokes MP, Abell K, Key J, Gispert S, Auburger G
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101072

Fusobacterium nucleatum drives gastric cancer metastasis via Gbp-CypA-NF-κB-mediated CXCL8 crosstalk between tumor cells and mast cells.

Yang X, Ning T, Zhang W, Hou S, Su J, Li W, Wu J
Cell communication and signaling : CCS 2025 Nov 28;24(1):6

Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer.

Xu H, Ma J, Li N, Xuan H, Lin S, Shen Y, Yin L, Wang P, Xu Q
NPJ precision oncology 2025 Nov 26;9(1):379

Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.

Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596

PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140.

Fan R, Zhu R, Cao X, Ye S, Gao F, Wu Y, Yao W, Liang G, Zhang Y
Molecular medicine (Cambridge, Mass.) 2025 Jun 3;31(1):216

Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multi-Selective Inhibitors in NRAS-Mutated Melanoma.

Foth M, Kim W, O'Toole KT, Murphy B, Justo-Garrido M, Boggaram SS, Ghazi PC, Brennan E, Wright MI, Shepherd T, Sanchez EC, Wang Y, Roth JA, Rees MG, Ronan MM, Jiang J, Wasko U, Jiang A, Becker C, Deacon D, Hu-Lieskovan S, Kinsey CG, Russel J, Hegde A, Garrido-Laguna I, Holderfield M, Singh M, McMahon M
bioRxiv : the preprint server for biology 2025 Dec 21;

A single-cell atlas reveals the tumorigenesis and microenvironment status of primary tracheobronchial tumors.

Shu C, Tang X, Zheng K, Zhang R, Zhou Y, Li M, Du W, Bai Y, Shen Y, Liu Y, Yang H, Yao F, Yan X, Ma N, Zhao J
NPJ precision oncology 2025 Dec 13;10(1):10

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.

Layish B, Goli R, Flick H, Huang SW, Zhang RZ, Kvaratskhelia M, Kane M
PLoS pathogens 2024 Mar;20(3):e1011830

PPIA dictates NRF2 stability to promote lung cancer progression.

Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J
Nature communications 2024 Jun 3;15(1):4703

METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.

Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573

Construction and validation of a prognostic signature based on necroptosis-related genes in hepatocellular carcinoma.

Peng YL, Wang LX, Li MY, Liu LP, Li RS
PloS one 2023;18(2):e0279744

Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.

Kanwore K, Kanwore K, Guo X, Xia Y, Zhou H, Zhang L, Adzika GK, Joseph AA, Abiola AA, Mu P, Kambey PA, Noah MLN, Gao D
Inflammation and regeneration 2023 Oct 13;43(1):49

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.

Layish B, Goli R, Flick H, Huang SW, Zhang RZ, Kvaratskhelia M, Kane M
bioRxiv : the preprint server for biology 2023 Nov 17;

Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.

Adamson SE, Li ZA, Hughes JW
Islets 2023 Dec 31;15(1):2252855

Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway.

Huang H, Jin K, Ouyang K, Jiang Z, Yang Z, Hu N, Dai Y, Zhang Y, Zhang Q, Han Y, Zhao J, Lin H, Wang C, Wang C, Sun X, Lu D, Zhu J, Li J
Frontiers in microbiology 2022;13:1046176

Identification and validation of necroptosis-related prognostic gene signature and tumor immune microenvironment infiltration characterization in esophageal carcinoma.

Sun K, Hong JJ, Chen DM, Luo ZX, Li JZ
BMC gastroenterology 2022 Jul 15;22(1):344

Intron retention is a stress response in sensor genes and is restored by Japanese herbal medicines: A basis for future clinical applications.

Vu TD, Ito N, Oshima K, Maruko A, Nishi A, Mizoguchi K, Odaguchi H, Kobayashi Y, Okada N
Gene 2022 Jul 1;830:146496

Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.

Zhang S, Huang W, Ren L, Ju X, Gong M, Rao J, Sun L, Li P, Ding Q, Wang J, Zhang QC
Cell research 2022 Jan;32(1):9-23

Cyclophilin A binds to AKT1 and facilitates the tumorigenicity of Epstein-Barr virus by mediating the activation of AKT/mTOR/NF-κB positive feedback loop.

Xin S, Liu L, Li Y, Yang J, Zuo L, Cao P, Yan Q, Li S, Yang L, Cui T, Lu J
Virologica Sinica 2022 Dec;37(6):913-921

Tacrolimus ameliorates podocyte injury by restoring FK506 binding protein 12 (FKBP12) at actin cytoskeleton.

Yasuda H, Fukusumi Y, Ivanov V, Zhang Y, Kawachi H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21983

CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.

Asamitsu S, Yabuki Y, Ikenoshita S, Kawakubo K, Kawasaki M, Usuki S, Nakayama Y, Adachi K, Kugoh H, Ishii K, Matsuura T, Nanba E, Sugiyama H, Fukunaga K, Shioda N
Science advances 2021 Jan;7(3)

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.

Pasetto L, Grassano M, Pozzi S, Luotti S, Sammali E, Migazzi A, Basso M, Spagnolli G, Biasini E, Micotti E, Cerovic M, Carli M, Forloni G, De Marco G, Manera U, Moglia C, Mora G, Traynor BJ, Chiò A, Calvo A, Bonetto V
Brain : a journal of neurology 2021 Dec 31;144(12):3710-3726

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis.

Pasetto L, Callegaro S, Corbelli A, Fiordaliso F, Ferrara D, Brunelli L, Sestito G, Pastorelli R, Bianchi E, Cretich M, Chiari M, Potrich C, Moglia C, Corbo M, Sorarù G, Lunetta C, Calvo A, Chiò A, Mora G, Pennuto M, Quattrone A, Rinaldi F, D'Agostino VG, Basso M, Bonetto V
Molecular neurodegeneration 2021 Aug 10;16(1):52

Cyclophilin A inhibits trophoblast migration and invasion in vitro and vivo through p38/ERK/JNK pathways and causes features of preeclampsia in mice.

Hu H, Jiang J, Chen Q, Wei S, Liu M, Chen X, Fan C, Ma J, Chen W, Wang X, Zhong M
Life sciences 2020 Nov 15;261:118351

Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome.

Xin S, Du S, Liu L, Xie Y, Zuo L, Yang J, Hu J, Yue W, Zhang J, Cao P, Zhu F, Lu J
Frontiers in microbiology 2019;10:2879

Exosomal cyclophilin A as a novel noninvasive biomarker for Epstein-Barr virus associated nasopharyngeal carcinoma.

Liu L, Zuo L, Yang J, Xin S, Zhang J, Zhou J, Li G, Tang J, Lu J
Cancer medicine 2019 Jun;8(6):3142-3151

Overexpression of Cyclophilin A in Human Periapical Lesions.

Wang Y, Liu G, Zhang J, Zhu L, Yu J, Zhu S, Lv F, Peng B
Journal of endodontics 2019 Dec;45(12):1496-1503

Correlation of five secretory proteins with the nasopharyngeal carcinoma metastasis and the clinical applications.

Tao Y, Wang K, Chen Z, Long L, Wu Q, Cui F, Zhu L, Xiang M, Jiang Y, Liang Y, Qiu S, Xiao Z, Yi B
Oncotarget 2017 Apr 25;8(17):29383-29394

Downregulation of Peptidylprolyl isomerase A promotes cell death and enhances doxorubicin-induced apoptosis in hepatocellular carcinoma.

Cheng S, Luo M, Ding C, Peng C, Lv Z, Tong R, Xiao H, Xie H, Zhou L, Wu J, Zheng S
Gene 2016 Oct 10;591(1):236-244

Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.

Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90

Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma.

Huang CF, Zhang L, Ma SR, Zhao ZL, Wang WM, He KF, Zhao YF, Zhang WF, Liu B, Sun ZJ
PloS one 2013;8(12):e83479

Proteomic methods reveal cyclophilin A function as a host restriction factor against rotavirus infection.

He H, Mou Z, Li W, Fei L, Tang Y, Zhang J, Yan P, Chen Z, Yang X, Shen Z, Li J, Wu Y
Proteomics 2013 Apr;13(7):1121-32

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis.

Nishioku T, Dohgu S, Koga M, Machida T, Watanabe T, Miura T, Tsumagari K, Terasawa M, Yamauchi A, Kataoka Y
Journal of inflammation (London, England) 2012 Nov 20;9(1):44

Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma.

Huang C, Sun Z, Sun Y, Chen X, Zhu X, Fan C, Liu B, Zhao Y, Zhang W
Histopathology 2012 Apr;60(5):793-803

Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue.

Huang CF, Sun ZJ, Zhao YF, Chen XM, Jia J, Zhang WF
Oral diseases 2011 Apr;17(3):328-34

CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

Watanabe A, Yoneda M, Ikeda F, Terao-Muto Y, Sato H, Kai C
Journal of virology 2010 May;84(9):4183-93

Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection.

Tian X, Zhao C, Zhu H, She W, Zhang J, Liu J, Li L, Zheng S, Wen YM, Xie Y
Journal of virology 2010 Apr;84(7):3373-81

Proteomic analysis of low dose arsenic and ionizing radiation exposure on keratinocytes.

Berglund SR, Santana AR, Li D, Rice RH, Rocke DM, Goldberg Z
Proteomics 2009 Apr;9(7):1925-38

Proteomic analysis of hepatitis B surface antigen positive transgenic mouse liver and decrease of cyclophilin A.

Zhao C, Fang CY, Tian XC, Wang L, Yang PY, Wen YM
Journal of medical virology 2007 Oct;79(10):1478-84

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: K-562 cells were subjected to SDS PAGE followed by western blot with 10720-1-AP(CYPA antibody) at dilution of 1:1500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using PPIA antibody 10720-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 10720-1-AP(CYPA antibody) at dilution of 1:200 (under 10x lens)
Sample type: tissue