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- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12277-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12277-1-AP, RRID:AB_2239384
- Product name
- SLC25A46 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SLC25A46 antibody (Cat. #12277-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells.
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Reanalysis of Exome Data Identifies Novel SLC25A46 Variants Associated with Leigh Syndrome.
A High-Density Human Mitochondrial Proximity Interaction Network.
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.
Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.
Santo-Domingo J, Lassueur S, Galindo AN, Alvarez-Illera P, Romero-Sanz S, Caldero-Escudero E, de la Fuente S, Dayon L, Wiederkehr A
Journal of cell science 2023 Apr 15;136(8)
Journal of cell science 2023 Apr 15;136(8)
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK
Science advances 2021 Nov 12;7(46):eabj0722
Science advances 2021 Nov 12;7(46):eabj0722
Reanalysis of Exome Data Identifies Novel SLC25A46 Variants Associated with Leigh Syndrome.
Li Q, Madden JA, Lin J, Shi J, Rosen SM, Schmitz-Abe K, Agrawal PB
Journal of personalized medicine 2021 Dec 2;11(12)
Journal of personalized medicine 2021 Dec 2;11(12)
A High-Density Human Mitochondrial Proximity Interaction Network.
Antonicka H, Lin ZY, Janer A, Aaltonen MJ, Weraarpachai W, Gingras AC, Shoubridge EA
Cell metabolism 2020 Sep 1;32(3):479-497.e9
Cell metabolism 2020 Sep 1;32(3):479-497.e9
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.
Steffen J, Vashisht AA, Wan J, Jen JC, Claypool SM, Wohlschlegel JA, Koehler CM
Molecular biology of the cell 2017 Mar 1;28(5):600-612
Molecular biology of the cell 2017 Mar 1;28(5):600-612
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.
Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, Des Rosiers C, Forest A, Lin ZY, Gingras AC, Mitchell G, McBride HM, Shoubridge EA
EMBO molecular medicine 2016 Sep;8(9):1019-38
EMBO molecular medicine 2016 Sep;8(9):1019-38
Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.
Wan J, Steffen J, Yourshaw M, Mamsa H, Andersen E, Rudnik-Schöneborn S, Pope K, Howell KB, McLean CA, Kornberg AJ, Joseph J, Lockhart PJ, Zerres K, Ryan MM, Nelson SF, Koehler CM, Jen JC
Brain : a journal of neurology 2016 Nov 1;139(11):2877-2890
Brain : a journal of neurology 2016 Nov 1;139(11):2877-2890
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 12277-1-AP(SLC25A46 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLC25A46 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SLC25A46. This antibody recognizes human, mouse, rat antigen. The SLC25A46 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
