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- Antigen structure
- References [17]
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- Product number
- 4058 - Provider product page
- Provider
- Cell Signaling Technology, Inc
- Proper citation
- Cell Signaling Technology Cat#4058, RRID:AB_331168
- Product name
- Phospho-Akt (Ser473) (193H12) Rabbit mAb
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Storage
- -20°C
Submitted references Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation.
Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.
Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.
Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.
Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.
Analysis of signaling events by dynamic phosphoflow cytometry.
Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation.
B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death.
Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells.
Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways.
EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling.
T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation.
Adjuvant-induced survival signaling in clonally expanded T cells is associated with transient increases in pAkt levels and sustained uptake of glucose.
The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants.
Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK
Molecular cell 2011 Sep 2;43(5):723-37
Molecular cell 2011 Sep 2;43(5):723-37
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT
Cell 2011 Sep 2;146(5):697-708
Cell 2011 Sep 2;146(5):697-708
The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation.
Dong A, Gupta A, Pai RK, Tun M, Lowe AW
The Journal of biological chemistry 2011 May 20;286(20):18301-10
The Journal of biological chemistry 2011 May 20;286(20):18301-10
Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.
Messal N, Mamessier E, Sylvain A, Celis-Gutierrez J, Thibult ML, Chetaille B, Firaguay G, Pastor S, Guillaume Y, Wang Q, Hirsch I, Nunès JA, Olive D
European journal of immunology 2011 Dec;41(12):3443-54
European journal of immunology 2011 Dec;41(12):3443-54
Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.
Chung YW, Kim HK, Kim IY, Yim MB, Chock PB
The Journal of biological chemistry 2011 Aug 26;286(34):29681-90
The Journal of biological chemistry 2011 Aug 26;286(34):29681-90
Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.
Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M
The American journal of pathology 2010 Jul;177(1):415-23
The American journal of pathology 2010 Jul;177(1):415-23
Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.
Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ
The Journal of biological chemistry 2010 Dec 31;285(53):41337-47
The Journal of biological chemistry 2010 Dec 31;285(53):41337-47
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.
Ramadani F, Bolland DJ, Garcon F, Emery JL, Vanhaesebroeck B, Corcoran AE, Okkenhaug K
Science signaling 2010 Aug 10;3(134):ra60
Science signaling 2010 Aug 10;3(134):ra60
Analysis of signaling events by dynamic phosphoflow cytometry.
Firaguay G, Nunès JA
Science signaling 2009 Sep 1;2(86):pl3
Science signaling 2009 Sep 1;2(86):pl3
Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation.
Billottet C, Banerjee L, Vanhaesebroeck B, Khwaja A
Cancer research 2009 Feb 1;69(3):1027-36
Cancer research 2009 Feb 1;69(3):1027-36
B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death.
Radhakrishnan S, Nguyen LT, Ciric B, Van Keulen VP, Pease LR
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1426-32
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1426-32
Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells.
Wong RC, Tellis I, Jamshidi P, Pera M, Pébay A
Stem cells and development 2007 Dec;16(6):989-1001
Stem cells and development 2007 Dec;16(6):989-1001
Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways.
Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh BH, Cooper ME, Chai Z
The Journal of biological chemistry 2007 Apr 20;282(16):11722-31
The Journal of biological chemistry 2007 Apr 20;282(16):11722-31
EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling.
Salvucci O, de la Luz Sierra M, Martina JA, McCormick PJ, Tosato G
Blood 2006 Nov 1;108(9):2914-22
Blood 2006 Nov 1;108(9):2914-22
T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation.
Simoncic PD, Bourdeau A, Lee-Loy A, Rohrschneider LR, Tremblay ML, Stanley ER, McGlade CJ
Molecular and cellular biology 2006 Jun;26(11):4149-60
Molecular and cellular biology 2006 Jun;26(11):4149-60
Adjuvant-induced survival signaling in clonally expanded T cells is associated with transient increases in pAkt levels and sustained uptake of glucose.
Sengupta S, Chilton PM, Mitchell TC
Immunobiology 2005;210(9):647-59
Immunobiology 2005;210(9):647-59
The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants.
Berthou S, Aebersold DM, Schmidt LS, Stroka D, Heigl C, Streit B, Stalder D, Gruber G, Liang C, Howlett AR, Candinas D, Greiner RH, Lipson KE, Zimmer Y
Oncogene 2004 Jul 8;23(31):5387-93
Oncogene 2004 Jul 8;23(31):5387-93
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