Ab087937

antibody from Aladdin Scientific

Targeting: AKT1 AKT, PKB, PRKBA, RAC, RAC-alpha

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

Ab087937

Provider

Aladdin Scientific

Product name

AKT1 Mouse mAb

Antibody type

Monoclonal

Description

Application:WB: 1/500 - 1/2000 IF/ICC: 1/200 - 1/1000 Flow: 1/200 - 1/400ELISA: 1/10000Protein FunctionPlays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.

Reactivity

Human, Mouse, Rat, Simian

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA 1-150


Isotype

IgG

Antibody clone number

1F7E10

Vial size

100_l,10_l,1ml,50_l

Concentration

1 mg/ml

Storage

Shipped at 4¡C. Store at +4¡C short term (1-2 weeks). Upon delivery aliquot. Store at -20¡C long term. Avoid freeze / thaw cycle.