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- Immunohistochemistry [2]
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- Product number
- 16840-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16840-1-AP, RRID:AB_2214569
- Product name
- USP13 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP13 antibody (Cat. #16840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Molecular Regulation of Transforming Growth Factor-β1-induced Thioredoxin-interacting Protein Ubiquitination and Proteasomal Degradation in Lung Fibroblasts: Implication in Pulmonary Fibrosis.
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer.
MicroRNA profiling reveals miR-145-5p inhibits goat myoblast differentiation by targeting the coding domain sequence of USP13.
Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.
Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T α-synuclein levels and aggregation.
USP13 Deficiency Aggravates Cigarette-smoke-induced Alveolar Space Enlargement.
Lipopolysaccharide reduces USP13 stability through c-Jun N-terminal kinase activation in Kupffer cells.
IL-37-induced activation of glycogen synthase kinase 3β promotes IL-1R8/Sigirr phosphorylation, internalization, and degradation in lung epithelial cells.
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.
USP13 serves as a tumor suppressor via the PTEN/AKT pathway in oral squamous cell carcinoma.
Amplification of USP13 drives non-small cell lung cancer progression mediated by AKT/MAPK signaling.
The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-α production in RBL-2H3 cells.
Chaperone-mediated autophagy degrades mutant p53.
Taleb SJ, Ye Q, Baoyinna B, Dedad M, Pisini D, Parinandi NL, Cantley LC, Zhao J, Zhao Y
Journal of respiratory biology and translational medicine 2024 Mar;1(1)
Journal of respiratory biology and translational medicine 2024 Mar;1(1)
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Ma C, Wang D, Tian Z, Gao W, Zang Y, Qian L, Xu X, Jia J, Liu Z
Oncogene 2023 Jul;42(29):2249-2262
Oncogene 2023 Jul;42(29):2249-2262
High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer.
Wang H, Chen S, Kang W, Ding B, Cui S, Zhou L, Zhang N, Luo H, Wang M, Zhang F, Zhao Z, Guo Z, Wang C, Li L, Wang Z, Chen X, Wang Y
Discover oncology 2023 Feb 23;14(1):25
Discover oncology 2023 Feb 23;14(1):25
MicroRNA profiling reveals miR-145-5p inhibits goat myoblast differentiation by targeting the coding domain sequence of USP13.
Zhang Z, Deng K, Kang Z, Wang F, Fan Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22370
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22370
Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.
Zhang T, Zheng J, Qiao L, Zhao W
Pathology, research and practice 2022 Jan;229:153705
Pathology, research and practice 2022 Jan;229:153705
Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T α-synuclein levels and aggregation.
Vajhøj C, Schmid B, Alik A, Melki R, Fog K, Holst B, Stummann TC
PloS one 2021;16(12):e0261536
PloS one 2021;16(12):e0261536
USP13 Deficiency Aggravates Cigarette-smoke-induced Alveolar Space Enlargement.
Gregory AD, Tran KC, Tamaskar AS, Wei J, Zhao J, Zhao Y
Cell biochemistry and biophysics 2021 Sep;79(3):485-491
Cell biochemistry and biophysics 2021 Sep;79(3):485-491
Lipopolysaccharide reduces USP13 stability through c-Jun N-terminal kinase activation in Kupffer cells.
Yu F, Li Y, Ye Q, Miao J, Taleb SJ, Zhao Y, Zhao J
Journal of cellular physiology 2021 Jun;236(6):4360-4368
Journal of cellular physiology 2021 Jun;236(6):4360-4368
IL-37-induced activation of glycogen synthase kinase 3β promotes IL-1R8/Sigirr phosphorylation, internalization, and degradation in lung epithelial cells.
Li L, Wei J, Suber TL, Ye Q, Miao J, Li S, Taleb SJ, Tran KC, Tamaskar AS, Zhao J, Zhao Y
Journal of cellular physiology 2021 Aug;236(8):5676-5685
Journal of cellular physiology 2021 Aug;236(8):5676-5685
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
Liao X, Li Y, Liu J, Zhang Y, Tan J, Kass DJ, Rojas M, Mallampalli RK, Zhao J, Zhao Y
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.
Guo J, Zhang J, Liang L, Liu N, Qi M, Zhao S, Su J, Liu J, Peng C, Chen X, Liu H
Journal of cellular and molecular medicine 2020 Apr;24(7):4324-4340
Journal of cellular and molecular medicine 2020 Apr;24(7):4324-4340
USP13 serves as a tumor suppressor via the PTEN/AKT pathway in oral squamous cell carcinoma.
Qu Z, Zhang R, Su M, Liu W
Cancer management and research 2019;11:9175-9183
Cancer management and research 2019;11:9175-9183
Amplification of USP13 drives non-small cell lung cancer progression mediated by AKT/MAPK signaling.
Wu Y, Zhang Y, Liu C, Zhang Y, Wang D, Wang S, Wu Y, Liu F, Li Q, Liu X, Zaky MY, Yan D, Liu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jun;114:108831
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jun;114:108831
The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
Li L, Wei J, Li S, Jacko AM, Weathington NM, Mallampalli RK, Zhao J, Zhao Y
EBioMedicine 2019 Jul;45:553-562
EBioMedicine 2019 Jul;45:553-562
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H
The Journal of cell biology 2015 Aug 31;210(5):705-16
The Journal of cell biology 2015 Aug 31;210(5):705-16
Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-α production in RBL-2H3 cells.
Yoshioka Y, Ye YQ, Okada K, Taniguchi K, Yoshida A, Sugaya K, Onose J, Koshino H, Takahashi S, Yajima A, Yajima S, Abe N
PloS one 2013;8(12):e80931
PloS one 2013;8(12):e80931
Chaperone-mediated autophagy degrades mutant p53.
Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J
Genes & development 2013 Aug 1;27(15):1718-30
Genes & development 2013 Aug 1;27(15):1718-30
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 16840-1-AP(USP13 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-USP13 (IP:16840-1-AP, 5ug; Detection:16840-1-AP 1:500) with HeLa cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 16840-1-AP(USP13 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP13 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP13. This antibody recognizes human,mouse,rat antigen. The USP13 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
