Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS9140 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GADD 45ÎÛ (S123) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 101-150 of Human GADD 45ÎÛ.
- Description
- Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45ÉÇ and GADD 45ÎÛ, have been shown to be induced by environmental stresses. GADD 45ÉÇ and GADD 45ÎÛ are thought to induce p38/JNK activation via MEKK4 activation.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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