10927-1-AP

antibody from Proteintech Group

Targeting: CXCL13 ANGIE, ANGIE2, BCA-1, BLC, BLR1L, SCYB13

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10927-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10927-1-AP, RRID:AB_2086050

Product name

CXCL13/BCA1 antibody

Antibody type

Polyclonal

Description

CXCL13/BCA1 antibody (Cat. #10927-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

The expression and significance of CXCL13 and CXCR5 in the tumor microenvironment of primary central nervous system diffuse large B-cell lymphoma.

Li C, Zhang L, Jin Q, Jiang H, Yue N, Wu C
Free radical biology & medicine 2026 Feb 16;244:197-209

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Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma.

Zhou S, Ye S, Chen L, Ge Q, Lu J, Anwaier A, Tian X, Wang Z, Zhu S, Chang K, Yang J, Li T, Zhang H, Ye D, Xiang J, Xu W
International journal of biological sciences 2025;21(9):3827-3851

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Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production.

Wang C, Zhang Y, Liu T, Mi Z, Shi P, Wang Z, Li W, Wang H, Liu H, Zhang F
Frontiers in immunology 2025;16:1541954

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Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.

Wu P, Liu S, Xu T, Zhao G
Current eye research 2025 Sep;50(9):894-902

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Development of an immune scoring system based on exosome-related gene expression for prognosis and treatment response prediction in breast cancer.

Ren X, Ma Y, Li J, Liu Y, Liao X, Lin R, Qiu Z
Discover oncology 2025 May 30;16(1):957

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Identification of CXCL13 as a Promising Biomarker for Immune Checkpoint Blockade Therapy and PARP Inhibitor Therapy in Ovarian Cancer.

Ding Y, Ye Z, Ding B, Feng S, Zhang Y, Shen Y
Molecular biotechnology 2025 Jun;67(6):2428-2442

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CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1-Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis.

Han J, Hong R, Cao C, Feng W, Zhuang W, Wang G, Tang J, Yang Y, Zhang C, Zhou A, Qu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2414550

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Enhanced immunotherapy response in lung adenocarcinoma patients with COPD: insights into tumor cells and immune microenvironment characteristics.

Huang Y, Liang B, Chen X, Li Z, Deng Y, Du J, Zhong Y, Lin X, Fu J, Xie J, Zhang X, Huang Z
Cell communication and signaling : CCS 2025 Jul 4;23(1):324

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Photo-metallo-immunotherapy: Fabricating Chromium-Based Nanocomposites to Enhance CAR-T Cell Infiltration and Cytotoxicity against Solid Tumors.

Zou Q, Liao K, Li G, Huang X, Zheng Y, Yang G, Luo M, Xue EY, Lan C, Wang S, Shen Y, Luo D, Ng DKP, Liu Q
Advanced materials (Deerfield Beach, Fla.) 2025 Jan;37(2):e2407425

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PD-1/ PD-L1 bispecific antibody IBI318 combined with lenvatinib in advanced non-small cell lung cancer with acquired resistance to immune checkpoint inhibitors: a phase II trial.

Zeng L, Ruan Z, Yan H, Qin H, Zeng Z, Zou C, Huang Z, Jiang W, Dai J, Xu S, Song L, Chen Y, Zhang Y, Zeng F, Wei S, Chen S, Liu L, Xiong Y, Wang Z, Deng J, Zhang X, Sun Y, Yang D, Zhou C, Yang H, Li Y, Deng L, Xu Q, Fang C, Chen X, Wang J, Li T, Zhang G, Zhou H, Yang N, Zhang Y
Nature communications 2025 Dec 15;17(1):567

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Lymph nodes molecular subtypes unravel lymph nodes heterogeneity and clinical implications in colorectal cancer.

Guan X, Zhang Y, Sun R, Wang G, Bi X, Zhang Z, Zan L, Meng Y, Liu Y, Guo J, Ma J, Li J, Hu H, Zhang Y, Zhang X, Liu M, Jiang B, Liu H, Zou S, Xi Y, Zhou H, Bai W, Wu D, Wang X
Nature communications 2025 Aug 22;16(1):7834

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Breast cancer during pregnancy of Luminal A type overexpressed CXCL13.

Nozaki F, Nakanishi Y, Tanino T, Ochi T, In R, Kajiura Y, Kida K, Takei J, Yoshida A, Kanomata N, Kitano A, Yamauchi H, Masuda S
Pathology international 2024 Oct;74(10):592-603

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CXCL13 promote angiogenesis by recruiting M2 macrophages and endothelial progenitor cells in beige adipose grafts.

Zhang X, Chen X, Li J, Liu Y, Luo S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 30;38(22):e70189

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The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma.

Wang Z, Zhao Y, Wo Y, Peng Y, Hu W, Wu Z, Liu P, Shang Y, Liu C, Chen X, Huang K, Chen Y, Hong H, Li F, Sun Y
Cancer letters 2024 Jul 1;593:216951

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CXC ligand 13 orchestrates an immunoactive microenvironment and enhances immunotherapy response in head and neck squamous cell carcinoma.

Lin X, Zhao X, Chen Y, Yang R, Dai Z, Li W, Lin C, Cao W
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241227312

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Single-cell transcriptome profiles the heterogeneity of tumor cells and microenvironments for different pathological endometrial cancer and identifies specific sensitive drugs.

Ren F, Wang L, Wang Y, Wang J, Wang Y, Song X, Zhang G, Nie F, Lin S
Cell death & disease 2024 Aug 7;15(8):571

---

A novel model associated with tumor microenvironment on predicting prognosis and immunotherapy in triple negative breast cancer.

Zhang J, Zhang M, Tian Q, Yang J
Clinical and experimental medicine 2023 Nov;23(7):3867-3881

---

Identification and Preliminary Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Hashimoto's Thyroiditis by Comprehensive Analysis.

Xi Z, Yang T, Huang T, Zhou J, Yang P
Biomedicines 2023 Nov 24;11(12)

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Single-cell and bulk RNA sequencing reveals Anoikis related genes to guide prognosis and immunotherapy in osteosarcoma.

Zhong C, Yang D, Zhong L, Xie W, Sun G, Jin D, Li Y
Scientific reports 2023 Nov 18;13(1):20203

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Identification of a novel immune gene panel in tongue squamous cell carcinoma.

Sun J, Guo F, Tang Q, Chen G, Peng J, Shen Y, Zhang J, Hu J, Yang C
American journal of translational research 2022;14(5):2801-2824

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Arabidopsis plastid carbonic anhydrase βCA5 is important for normal plant growth.

Weerasooriya HN, DiMario RJ, Rosati VC, Rai AK, LaPlace LM, Filloon VD, Longstreth DJ, Moroney JV
Plant physiology 2022 Nov 28;190(4):2173-2186

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A Standardized Analysis of Tertiary Lymphoid Structures in Human Melanoma: Disease Progression- and Tumor Site-Associated Changes With Germinal Center Alteration.

Werner F, Wagner C, Simon M, Glatz K, Mertz KD, Läubli H, Griss J, Wagner SN
Frontiers in immunology 2021;12:675146

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Single-Cell RNA-seq Reveals Characteristics of Malignant Cells and Immune Microenvironment in Subcutaneous Panniculitis-Like T-Cell Lymphoma.

Li Z, Wang H, Dong R, Man J, Sun L, Qian X, Zhu X, Cao P, Yu Y, Le J, Fu Y, Wang P, Jiang W, Shen C, Ma Y, Chen L, Xu Y, Shi J, Zhang H, Qian M, Zhai X
Frontiers in oncology 2021;11:611580

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MIN score predicts primary response to infliximab/adalimumab and vedolizumab therapy in patients with inflammatory bowel diseases.

Shi Y, He W, Zhong M, Yu M
Genomics 2021 Jul;113(4):1988-1998

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Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy.

Liu W, Zhou J, Niu F, Pu F, Wang Z, Huang M, Zhao X, Yang L, Tao P, Xia P, Feng J
Experimental and therapeutic medicine 2020 Sep;20(3):1889-1898

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Defined lifestyle and germline factors predispose Asian populations to gastric cancer.

Suzuki A, Katoh H, Komura D, Kakiuchi M, Tagashira A, Yamamoto S, Tatsuno K, Ueda H, Nagae G, Fukuda S, Umeda T, Totoki Y, Abe H, Ushiku T, Matsuura T, Sakai E, Ohshima T, Nomura S, Seto Y, Shibata T, Rino Y, Nakajima A, Fukayama M, Ishikawa S, Aburatani H
Science advances 2020 May;6(19):eaav9778

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Immune profiling reveals prognostic genes in high-grade serous ovarian cancer.

Wu Y, Xia L, Zhao P, Deng Y, Guo Q, Zhu J, Chen X, Ju X, Wu X
Aging 2020 Jun 16;12(12):11398-11415

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B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.

Griss J, Bauer W, Wagner C, Simon M, Chen M, Grabmeier-Pfistershammer K, Maurer-Granofszky M, Roka F, Penz T, Bock C, Zhang G, Herlyn M, Glatz K, Läubli H, Mertz KD, Petzelbauer P, Wiesner T, Hartl M, Pickl WF, Somasundaram R, Steinberger P, Wagner SN
Nature communications 2019 Sep 13;10(1):4186

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Identification of CXCL13 as a potential biomarker in clear cell renal cell carcinoma via comprehensive bioinformatics analysis.

Xu T, Ruan H, Song Z, Cao Q, Wang K, Bao L, Liu D, Tong J, Yang H, Chen K, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109264

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MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.

Xu W, Li J, Tian H, Wang R, Feng Y, Tang J, Jia J
Molecular medicine reports 2019 Nov;20(5):4594-4602

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The role of high serum CXCL13 level in Waldenström macroglobulinemia.

Wu YY, Cai H, Zhao AL, Zhang L, Zhou DB, Cao XX, Li J
Leukemia research 2019 Jun;81:50-55

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Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.

Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, Lee DC, Draghici S, Gotsch F, Kusanovic JP, Hassan SS, Kim JS
Journal of immunology (Baltimore, Md. : 1950) 2009 Mar 15;182(6):3919-27

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A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation.

Nhan-Chang CL, Romero R, Kusanovic JP, Gotsch F, Edwin SS, Erez O, Mittal P, Kim CJ, Kim MJ, Espinoza J, Friel LA, Vaisbuch E, Than NG, Mazaki-Tovi S, Hassan SS
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2008 Nov;21(11):763-75

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human placenta tissue were subjected to SDS PAGE followed by western blot with 10927-1-AP(CXCL13 antibody) at dilution of 1:200

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The CXCL13 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CXCL13. This antibody recognizes human antigen. The CXCL13 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

10927-1-AP.pdf

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