13128-1-AP

antibody from Proteintech Group

Targeting: FDFT1 SQS

Provider product page for 13128-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 13128-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13128-1-AP, RRID:AB_2294094
Product name: FDFT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated FDFT1 antibody (Cat. #13128-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FDFT1 protein structure - 13128-1-AP shown in red.

Submitted references The compound LY295427 antagonizes 25-hydroxycholesterol through binding to INSIG.

Wen XY, Zhang DJ, He LM, Sun M, Jiang Q, Zhu Y, Song BL, Qiu WW, Lu XY
Journal of lipid research 2026 Apr;67(4):101015

Proteomics of stress-induced cardiomyopathy: insights from differential expression, protein interaction networks, and functional pathway enrichment in an isoproterenol-induced TTC mouse model.

Tian L, Liu B, Ren Y, Cui J, Pang Z
PeerJ 2025;13:e18984

Suppression of SREBP by a transmembrane protein mutated in cardiomyopathy.

Takemoto Y, Tserendagva M, Uesugi M
The Journal of biological chemistry 2025 Oct;301(10):110644

Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment.

Tao X, Gao Y, Jin Z, Lu S, Li Z, Guo S, Fan Q, Li J, Qiao C, Lei H, Zhang Z, Zhao C, Wu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157185

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.

Rattani A, Anderson C, Trim WV, Garita E, Imada S, Khawaled S, Shin H, Zhang J, Yilmaz ÖH, Kirschner M
bioRxiv : the preprint server for biology 2025 Nov 18;

DHODH Blockade Induces Ferroptosis in Neuroblastoma by Modulating the Mevalonate Pathway.

Shir JC, Chen PY, Kuo CH, Hsieh CH, Chang HY, Lee HC, Huang CH, Hsu CH, Hsu WM, Huang HC, Juan HF
Molecular & cellular proteomics : MCP 2025 Jul;24(7):101014

THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer.

Zeng Y, Xu Z, Huang J, Yi Q, Chen X, Wang J, Du Z, Tian J, Yan Y
Breast cancer research : BCR 2025 Jul 6;27(1):124

Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.

Wang X, Suzuki S, Yuan H, Hirata-Tsuchiya S, Fahreza RR, Nemoto E, Shiba H, Yamada S
Journal of dental sciences 2025 Jan;20(1):560-568

Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.

Kamchonemenukool S, Koh YC, Ho PY, Pan MH, Weerawatanakorn M
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442

A Super-Enhancer-Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration-Resistant Prostate Cancer.

Jiang L, Wang J, Peng G, Zhang H, Fang J, Gao Y, Lou E, Liu Y, Ding W, Liu B, Mao Q, Jiang L, Liu A, Li X, Hu S, Ma Q, Zheng Y, Zhao Z, Shi X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e01284

Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells.

He F, Zhou Y, Fu J, Chang S, Cui X, Feng Z, Zhao L, Li X
iScience 2025 Aug 15;28(8):112853

PKMYT1 knockdown inhibits cholesterol biosynthesis and promotes the drug sensitivity of triple-negative breast cancer cells to atorvastatin.

Gao W, Guo X, Sun L, Gai J, Cao Y, Zhang S
PeerJ 2024;12:e17749

Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development.

Wang W, Wang Y, Su L, Zhang M, Zhang T, Zhao J, Ma H, Zhang D, Ji F, Jiao RD, Li H, Xu Y, Chen L, Jiao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2308508

Identification of FDA-approved drugs that increase mevalonate kinase in hyper IgD syndrome.

Politiek FA, Turkenburg M, Koster J, Ofman R, Waterham HR
Journal of inherited metabolic disease 2024 Mar;47(2):302-316

RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence.

Hunt BG, Davis JC, Fox LH, Vicente-Muñoz S, Lester C, Wells SI, Waltz SE
Oncogene 2023 May;42(21):1716-1727

Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma.

Tran GB, Ding J, Ye B, Liu M, Yu Y, Zha Y, Dong Z, Liu K, Sudarshan S, Ding HF
Cancer research 2023 Jul 5;83(13):2248-2261

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.

Xu R, Song J, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Cell death & disease 2023 Aug 4;14(8):497

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

Zheng YK, Zhou ZS, Wang GZ, Tu JY, Cheng HB, Ma SZ, Ke C, Wang Y, Jian QP, Shu YH, Wu XW
Cell death & disease 2023 Apr 1;14(4):234

Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.

Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX
Stem cells international 2022;2022:4363632

Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC.

Huang R, Zhang C, Wang X, Zou X, Xiang Z, Wang Z, Gui B, Lin T, Hu H
Cancer medicine 2022 Nov;11(21):3993-4004

Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.

Guo C, Wan R, He Y, Lin SH, Cao J, Qiu Y, Zhang T, Zhao Q, Niu Y, Jin Y, Huang HY, Wang X, Tan L, Thomas RK, Zhang H, Chen L, Wong KK, Hu L, Ji H
Nature cancer 2022 May;3(5):614-628

Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression.

Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, He L
Cancer science 2022 Mar;113(3):971-985

Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.

Xu XY, Choi HS, Park SY, Kim JK, Seo KH, Kim H, Kim YJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer.

Biancur DE, Kapner KS, Yamamoto K, Banh RS, Neggers JE, Sohn ASW, Wu W, Manguso RT, Brown A, Root DE, Aguirre AJ, Kimmelman AC
Cell metabolism 2021 Jan 5;33(1):199-210.e8

20(S)-Rg3 upregulates FDFT1 via reducing miR-4425 to inhibit ovarian cancer progression.

Lu J, Zhou Y, Zheng X, Chen L, Tuo X, Chen H, Xue M, Chen Q, Chen W, Li X, Zhao L
Archives of biochemistry and biophysics 2020 Oct 30;693:108569

Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.

Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.

Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, Birsoy K
Nature 2019 Mar;567(7746):118-122

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.

Mahoney CE, Pirman D, Chubukov V, Sleger T, Hayes S, Fan ZP, Allen EL, Chen Y, Huang L, Liu M, Zhang Y, McDonald G, Narayanaswamy R, Choe S, Chen Y, Gross S, Cianchetta G, Padyana AK, Murray S, Liu W, Marks KM, Murtie J, Dorsch M, Jin S, Nagaraja N, Biller SA, Roddy T, Popovici-Muller J, Smolen GA
Nature communications 2019 Jan 9;10(1):96

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: COLO 320 cells were subjected to SDS PAGE followed by western blot with 13128-1-AP(SQS antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SQS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SQS. This antibody recognizes human, mouse, rat antigen. The SQS antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13128-1-AP.pdf

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