BS8481

antibody from Bioworld Technology, Inc
Targeting: ROR2 BDB, BDB1, NTRKR2
Provider product page for BS8481
Western blot
Immunohistochemistry

Antibody data

Product number
BS8481 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ROR2 polyclonal antibody
Antibody type
Polyclonal
Antigen
BDB; BDB1; Brachydactyly type B; Neurotrophic tyrosine kinase; receptor related 2; NTRKR2;
Description
ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1 or the autosomal recessive skeletal disorder, Robinow syndrome.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ROR2 protein structure - BS8481 shown in red.