Ab099353

antibody from Aladdin Scientific
Targeting: DDB2 DDBB, FLJ34321, UV-DDB2, XPE
Provider product page for Ab099353

Antibody data

Product number
Ab099353 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant DDB2 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human DDB2 Antibody, Recombinant (R09-1D5), could be used for WB and so on.Application:WB: 1/500-1/1000Protein FunctionRequired for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 350-427
Antibody clone number
R09-1D5
Vial size
100μl,10μl,1ml,50μl
Concentration
0,4 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
DDB2 protein structure - Ab099353 shown in red.