ABIN117955

antibody from antibodies-online

Targeting: DDB2 DDBB, FLJ34321, UV-DDB2, XPE

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

ABIN117955

Provider

antibodies-online

Product name

anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 419-427), (C-Term) antibody

Antibody type

Polyclonal

Description

Processed by delipidation and defibrination followed by sterile filtration

Reactivity

Human, Mouse

Host

Rabbit

Antigen sequence

1 mapkkrpetq ktseivlrpr nkrsrsple
l epeakklcak gsgpsrrcds dclwvgla
gp 61 qilppcrsiv rtlhqhklgr aswp
svqqgl qqsflhtlds yrilqkaapf drr
atslawh 121 pthpstvavg skggdimlwn
fgikdkptfi kgigaggsit glkfnplnt
n qfyassmegt 181 trlqdfkgni lrvf
assdti niwfcsldvs assrmvvtgd nvg
nvillnm dgkelwnlrm 241 hkkkvthval
npccdwflat asvdqtvkiw dlrqvrgka
s flyslphrhp vnaacfspdg 301 arll
ttdqks eirvysasqw dcplgliphp hrh
fqhltpi kaawhprynl ivvgrypdpn 36
1 fksctpyelr tidvfdgnsg kmmcqlydp
e ssgisslnef npmgdtlasa mgyhiliw
sq 421 eeartrk


Epitope

C-Term, AA 419-427

Vial size

0.1 mL

Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.

Handling

Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light

References

Submitted references

Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.

Luijsterburg MS, Goedhart J, Moser J, Kool H, Geverts B, Houtsmuller AB, Mullenders LH, Vermeulen W, van Driel R
Journal of cell science 2007 Aug 1;120(Pt 15):2706-16

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Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.

Inoki T, Yamagami S, Inoki Y, Tsuru T, Hamamoto T, Kagawa Y, Mori T, Endo H
Biochemical and biophysical research communications 2004 Feb 20;314(4):1036-43

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Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53.

Itoh T, O'Shea C, Linn S
Molecular and cellular biology 2003 Nov;23(21):7540-53

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In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product.

Fitch ME, Nakajima S, Yasui A, Ford JM
The Journal of biological chemistry 2003 Nov 21;278(47):46906-10

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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y
Cell 2003 May 2;113(3):357-67

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True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.

Rapić-Otrin V, Navazza V, Nardo T, Botta E, McLenigan M, Bisi DC, Levine AS, Stefanini M
Human molecular genetics 2003 Jul 1;12(13):1507-22

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Ubiquitin and its kin: how close are the family ties?

Jentsch S, Pyrowolakis G
Trends in cell biology 2000 Aug;10(8):335-42