Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MAB21091 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Rat Monoclonal IL-27R alpha/WSX-1/TCCR Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse IL-27 R alpha/WSX-1/TCCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse gp130 or recombinant human IL-27 R alpha is observed.
- Reactivity
- Mouse
- Host
- Rat
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.
Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ
Nature immunology 2013 Oct;14(10):1054-63
Nature immunology 2013 Oct;14(10):1054-63
Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.
Pradhan A, Lambert QT, Reuther GW
Proceedings of the National Academy of Sciences of the United States of America 2007 Nov 20;104(47):18502-7
Proceedings of the National Academy of Sciences of the United States of America 2007 Nov 20;104(47):18502-7
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: IL-27 R alpha/WSX-1/TCCR Antibody (263503) [MAB21091] - Analysis using Alexa Fluor (R) 647 conjugate of MAB21091. Mouse splenocytes were stained with 0.1 ug of Rat Anti-Mouse IL-27R alpha/WSX-1/TCCR Alexa Fluor 647-conjugated Monoclonal Antibody (Catalog # FAB21091R, filled histogram) or isotype control antibody (Catalog # IC013R, open histogram).